ONTOLOGY REPORT - ANNOTATIONS
Term: DNA-(apurinic or apyrimidinic site) endonuclease activity
Accession: GO:0003906
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Definition: Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
Comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Synonyms: exact_synonym: AP deoxyendoribonuclease activity; abasic deoxyendoribonuclease activity; apurinic deoxyendoribonuclease activity; apurinic/apyrimidinic endodeoxyribonuclease activity; apyrimidinic deoxyendoribonuclease activity; deoxyribonuclease (apurinic or apyrimidinic) activity
broad_synonym: UV endonuclease
related_synonym: endonuclease VIII activity
xref: reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break"; reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site"; reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)"
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
enables
ISS IBA ISO
GO_REF:0000024 GO_REF:0000033 (PMID:15707971), (PMID:18973764), (PMID:19188445), (PMID:24703901), (PMID:8932386)
UniProt GO_Central RGD
PMID:8932386 PMID:15707971 PMID:18973764 PMID:19188445 PMID:24703901
GO_REF:0000024 GO_REF:0000033
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Apex2
apurinic/apyrimidinic endodeoxyribonuclease 2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439
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Aplf
aprataxin and PNKP like factor
enables
ISO IBA
(PMID:17396150) GO_REF:0000033
RGD GO_Central
PMID:17396150
GO_REF:0000033
NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633
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Hmces
5-hydroxymethylcytosine binding, ES cell specific
NOT|enables
ISS ISO
GO_REF:0000024 (PMID:30554877)
UniProt RGD
PMID:30554877
GO_REF:0000024
NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616
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Hmga1
high mobility group AT-hook 1
enables
ISO
(PMID:19465398)
RGD
PMID:19465398
NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
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Hmga2
high mobility group AT-hook 2
enables
ISS ISO
GO_REF:0000024 (PMID:19465398)
UniProt RGD
PMID:19465398
GO_REF:0000024
NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
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Neil1
nei-like DNA glycosylase 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
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Neil3
nei-like DNA glycosylase 3
enables
ISO IBA
(PMID:19170771) (PMID:20185759) GO_REF:0000033
RGD GO_Central
PMID:19170771 PMID:20185759
GO_REF:0000033
NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527
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Nthl1
nth-like DNA glycosylase 1
enables
ISO IBA
(PMID:8990169), (PMID:9927729) (PMID:9743625) GO_REF:0000033
RGD GO_Central
PMID:8990169 PMID:9743625 PMID:9927729
GO_REF:0000033
NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957
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Rps3
ribosomal protein S3
enables
ISO IEA
(PMID:15707971), (PMID:16737853), (PMID:18610840), (PMID:19059439), (PMID:7775413) GO_REF:0000107
RGD Ensembl
PMID:7775413 PMID:15707971 PMID:16737853 PMID:18610840 PMID:19059439
GO_REF:0000107
NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
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Rps3l1
ribosomal protein S3 like 1
enables
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr 3:51,559,683...51,560,522
Ensembl chr 3:51,559,683...51,560,524
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Alkbh1
alkB homolog 1, histone H2A dioxygenase
enables
ISO
(PMID:19959401)
RGD
PMID:19959401
NCBI chr 6:107,068,301...107,088,784
Ensembl chr 6:107,068,475...107,088,759
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Neil2
nei-like DNA glycosylase 2
enables
IEA
GO_REF:0000003
UniProt
GO_REF:0000003
NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863
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Neil3
nei-like DNA glycosylase 3
enables
IEA
GO_REF:0000003
UniProt
GO_REF:0000003
NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527
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Nthl1
nth-like DNA glycosylase 1
enables
ISO
(PMID:8990169)
RGD
PMID:8990169
NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957
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Ogg1
8-oxoguanine DNA glycosylase
enables
IEA
GO_REF:0000003 GO_REF:0000116
UniProt RHEA
GO_REF:0000003 GO_REF:0000116
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Polb
DNA polymerase beta
enables
ISO
(PMID:9614142)
RGD
PMID:9614142
NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
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Rps3
ribosomal protein S3
enables
IEA
GO_REF:0000003 GO_REF:0000116
UniProt RHEA
GO_REF:0000003 GO_REF:0000116
NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
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Rps3l1
ribosomal protein S3 like 1
enables
IEA
GO_REF:0000003
UniProt
GO_REF:0000003
NCBI chr 3:51,559,683...51,560,522
Ensembl chr 3:51,559,683...51,560,524
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
enables
ISO IEA ISS
(PMID:11160897), (PMID:11286553), (PMID:1627644), (PMID:9804798) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:1627644 PMID:9804798 PMID:11160897 PMID:11286553
GO_REF:0000024 GO_REF:0000107
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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