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ONTOLOGY REPORT - ANNOTATIONS

Term:U2-type precatalytic spliceosome
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Accession:GO:0071005 term browser browse the term
Definition:A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
Synonyms:exact_synonym: major precatalytic spliceosome
 narrow_synonym: GT-AG precatalytic spliceosome;   mammalian U2-type spliceosomal complex B;   mammalian U2-type spliceosomal complex B1
 related_synonym: yeast U12-type spliceosomal complex A2-1


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U2-type precatalytic spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BUD13 BUD13 homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr11:111,583,588...111,610,703
Ensembl chr11:115,517,647...115,545,098 		JBrowse link
G CWC22 CWC22 spliceosome associated protein homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr2B:67,198,535...67,261,588
Ensembl chr2B:184,901,960...184,945,273 		JBrowse link
G CWC27 CWC27 spliceosome associated cyclophilin part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:48,984,546...49,235,398
Ensembl chr 5:50,635,204...50,879,742 		JBrowse link
G DHX16 DEAH-box helicase 16 part_of IEA Ensembl GO_REF:0000107 NCBI chr 6:30,397,774...30,417,758
Ensembl chr 6:31,267,669...31,287,435 		JBrowse link
G EFTUD2 elongation factor Tu GTP binding domain containing 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr17:12,423,198...12,472,462
Ensembl chr17:12,595,715...12,644,147 		JBrowse link
G IK IK cytokine part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:136,012,381...136,027,099
Ensembl chr 5:142,129,130...142,143,393 		JBrowse link
G LOC100974064 small nuclear ribonucleoprotein E part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:67,731,954...67,732,434
Ensembl chr 1:183,755,392...183,764,937 		JBrowse link
G LSM2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated part_of IEA Ensembl GO_REF:0000107 NCBI chr 6:31,458,514...31,468,126
Ensembl chr 6:32,344,669...32,354,631 		JBrowse link
G LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated part_of IEA Ensembl GO_REF:0000107 NCBI chr 3:14,097,035...14,165,942
Ensembl chr 3:14,437,497...14,456,726 		JBrowse link
G LSM4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) UniProt PMID:28781166 NCBI chr19:17,785,580...17,801,866
Ensembl chr19:18,757,390...18,773,812 		JBrowse link
G LSM5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) UniProt PMID:28781166 NCBI chr 7:33,094,545...33,104,489 JBrowse link
G LSM6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:138,514,194...138,528,575
Ensembl chr 4:150,171,648...150,185,947 		JBrowse link
G LSM7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated part_of IEA Ensembl GO_REF:0000107 NCBI chr19:1,330,469...1,337,610
Ensembl chr19:2,302,280...2,313,255 		JBrowse link
G LSM8 LSM8 homolog, U6 small nuclear RNA associated part_of ISO (PMID:28781166) UniProt PMID:28781166 NCBI chr 7:110,150,584...110,160,864 JBrowse link
G MAGOH mago homolog, exon junction complex subunit part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:52,499,829...52,511,710
Ensembl chr 1:54,099,198...54,111,142 		JBrowse link
G MAGOHB mago homolog B, exon junction complex subunit part_of IEA Ensembl GO_REF:0000107 NCBI chr12:10,632,174...10,639,758
Ensembl chr12:10,898,716...10,905,958 		JBrowse link
G MFAP1 microfibril associated protein 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr15:22,764,678...22,784,934
Ensembl chr15:40,856,392...40,875,376 		JBrowse link
G PHF5A PHD finger protein 5A part_of IEA Ensembl GO_REF:0000107 NCBI chr22:22,353,811...22,362,899
Ensembl chr22:40,441,275...40,450,174 		JBrowse link
G PRPF3 pre-mRNA processing factor 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:125,666,604...125,698,591
Ensembl chr 1:129,320,605...129,348,214 		JBrowse link
G PRPF31 pre-mRNA processing factor 31 part_of IEA Ensembl GO_REF:0000107 NCBI chr19:51,048,133...51,064,394
Ensembl chr19:59,891,070...59,907,159 		JBrowse link
G PRPF38A pre-mRNA processing factor 38A part_of IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr 1:51,666,415...51,680,012
Ensembl chr 1:53,273,712...53,287,459 		JBrowse link
G PRPF4 pre-mRNA splicing tri-snRNP complex factor PRPF4 part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:84,373,457...84,390,622
Ensembl chr 9:112,745,455...112,763,725 		JBrowse link
G PRPF6 pre-mRNA processing factor 6 part_of IEA Ensembl GO_REF:0000107 Ensembl chr20:61,899,076...61,948,088 JBrowse link
G PRPF8 pre-mRNA processing factor 8 part_of IEA Ensembl GO_REF:0000107 NCBI chr17:1,635,991...1,669,703
Ensembl chr17:1,532,579...1,565,254 		JBrowse link
G RBMX2 RNA binding motif protein X-linked 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:119,528,923...119,540,319
Ensembl chr  X:129,820,864...129,831,902 		JBrowse link
G RNF113A ring finger protein 113A part_of IEA Ensembl GO_REF:0000107 NCBI chr  X:108,934,081...108,935,376
Ensembl chr  X:119,328,911...119,329,942 		JBrowse link
G SART1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP part_of IEA Ensembl GO_REF:0000107 NCBI chr11:61,326,262...61,343,475
Ensembl chr11:64,654,470...64,670,720 		JBrowse link
G SF3A1 splicing factor 3a subunit 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr22:11,369,772...11,392,998
Ensembl chr22:29,172,536...29,194,735 		JBrowse link
G SF3A2 splicing factor 3a subunit 2 part_of ISO (PMID:29360106) UniProt PMID:29360106 NCBI chr19:1,247,812...1,259,984 JBrowse link
G SF3A3 splicing factor 3a subunit 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:37,230,553...37,264,167
Ensembl chr 1:38,575,122...38,612,009 		JBrowse link
G SF3B1 splicing factor 3b subunit 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr2B:84,633,272...84,678,602
Ensembl chr2B:202,530,200...202,573,346 		JBrowse link
G SF3B2 splicing factor 3b subunit 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr11:61,416,764...61,433,334
Ensembl chr11:64,743,629...64,759,772 		JBrowse link
G SF3B3 splicing factor 3b subunit 3 part_of IEA Ensembl GO_REF:0000107 NCBI chr16:54,442,510...54,490,950
Ensembl chr16:70,361,068...70,410,042 		JBrowse link
G SF3B4 splicing factor 3b subunit 4 part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:125,268,113...125,273,405
Ensembl chr 1:128,924,317...128,929,610 		JBrowse link
G SF3B5 splicing factor 3b subunit 5 part_of IEA Ensembl GO_REF:0000107 NCBI chr 6:141,873,848...141,874,584
Ensembl chr 6:146,594,201...146,594,461 		JBrowse link
G SMU1 SMU1 DNA replication regulator and spliceosomal factor part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:32,819,539...32,851,273
Ensembl chr 9:33,628,027...33,659,539 		JBrowse link
G SNIP1 Smad nuclear interacting protein 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:36,807,488...36,827,347
Ensembl chr 1:38,155,375...38,176,803 		JBrowse link
G SNRNP200 small nuclear ribonucleoprotein U5 subunit 200 part_of IEA Ensembl GO_REF:0000107 NCBI chr2A:103,010,083...103,040,958
Ensembl chr2A:97,197,137...97,228,511 		JBrowse link
G SNRPA1 small nuclear ribonucleoprotein polypeptide A' part_of IEA Ensembl GO_REF:0000107 NCBI chr15:80,006,167...80,020,319
Ensembl chr15:99,289,668...99,303,839 		JBrowse link
G SNRPB small nuclear ribonucleoprotein polypeptides B and B1 part_of IEA Ensembl GO_REF:0000107 NCBI chr20:2,571,393...2,580,642
Ensembl chr20:2,335,499...2,344,763 		JBrowse link
G SNRPB2 small nuclear ribonucleoprotein polypeptide B2 part_of IEA Ensembl GO_REF:0000107 NCBI chr20:16,690,562...16,701,964
Ensembl chr20:16,670,826...16,682,418 		JBrowse link
G SNRPD1 small nuclear ribonucleoprotein D1 polypeptide part_of IEA Ensembl GO_REF:0000107 NCBI chr18:14,851,041...14,869,042
Ensembl chr18:18,488,929...18,506,284 		JBrowse link
G SNRPD2 small nuclear ribonucleoprotein D2 polypeptide part_of IEA Ensembl GO_REF:0000107 NCBI chr19:42,692,963...42,697,512
Ensembl chr19:51,230,822...51,235,661 		JBrowse link
G SNRPD3 small nuclear ribonucleoprotein D3 polypeptide part_of IEA Ensembl GO_REF:0000107 NCBI chr22:5,361,886...5,378,465
Ensembl chr22:22,227,328...22,246,676 		JBrowse link
G SNRPE small nuclear ribonucleoprotein polypeptide E part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:179,466,263...179,474,779
Ensembl chr 1:183,755,392...183,764,937 		JBrowse link
G SNRPF small nuclear ribonucleoprotein polypeptide F part_of ISO (PMID:28781166) UniProt PMID:28781166 NCBI chr12:93,452,446...93,459,691
Ensembl chr12:96,841,638...96,886,039 		JBrowse link
G SNRPG small nuclear ribonucleoprotein polypeptide G part_of ISO (PMID:28781166) UniProt PMID:28781166 NCBI chr2A:70,335,547...70,347,970
Ensembl chr2A:71,451,225...71,463,884 		JBrowse link
G SNU13 small nuclear ribonucleoprotein 13 part_of IEA Ensembl GO_REF:0000107 NCBI chr22:22,567,285...22,582,257
Ensembl chr22:40,653,338...40,669,706 		JBrowse link
G SRRM2 serine/arginine repetitive matrix 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr16:1,612,386...1,631,177
Ensembl chr16:2,865,810...2,884,902 		JBrowse link
G TXNL4A thioredoxin like 4A part_of IEA Ensembl GO_REF:0000107 NCBI chr18:73,618,302...73,679,603
Ensembl chr18:76,937,460...76,952,428 		JBrowse link
G WBP4 WW domain binding protein 4 part_of IEA Ensembl GO_REF:0000107 NCBI chr13:22,263,547...22,286,071
Ensembl chr13:40,852,971...40,875,173 		JBrowse link
G ZMAT2 zinc finger matrin-type 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:136,065,016...136,071,333
Ensembl chr 5:142,180,981...142,187,292 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17180
    protein-containing complex 5905
      ribonucleoprotein complex 950
        spliceosomal complex 204
          U2-type spliceosomal complex 98
            U2-type precatalytic spliceosome 52
Path 2
Term Annotations click to browse term
  cellular_component 17180
    cellular anatomical entity 16965
      organelle 12494
        intracellular organelle 12075
          intracellular membrane-bounded organelle 10860
            nucleus 6800
              nuclear protein-containing complex 1236
                spliceosomal complex 204
                  U2-type spliceosomal complex 98
                    U2-type precatalytic spliceosome 52
paths to the root