PRPF8 (pre-mRNA processing factor 8) - Rat Genome Database

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Gene: PRPF8 (pre-mRNA processing factor 8) Pan paniscus
Analyze
Symbol: PRPF8
Name: pre-mRNA processing factor 8
RGD ID: 11840053
Description: ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); metallopeptidase activity (inferred); pre-mRNA intronic binding (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN retinitis pigmentosa pathway; spliceosome pathway; ASSOCIATED WITH Developmental Disease (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN small nuclear ribonucleoprotein complex (ortholog); U4/U6 x U5 tri-snRNP complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pre-mRNA-processing-splicing factor 8; PRP8 pre-mRNA processing factor 8 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,223,458 - 9,257,176 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,189,660 - 11,223,215 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,635,991 - 1,669,703 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,532,579 - 1,565,254 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,532,579 - 1,565,254 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRPF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,223,458 - 9,257,176 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,189,660 - 11,223,215 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,635,991 - 1,669,703 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,532,579 - 1,565,254 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,532,579 - 1,565,254 (-)Ensemblpanpan1.1panPan2
PRPF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,650,629 - 1,684,867 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,650,629 - 1,684,867 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,553,923 - 1,588,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,500,673 - 1,534,926 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,500,673 - 1,534,850NCBI
Celera171,569,279 - 1,603,532 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,453,297 - 1,487,547 (-)NCBIHuRef
CHM1_1171,562,693 - 1,596,948 (-)NCBICHM1_1
T2T-CHM13v2.0171,539,419 - 1,573,935 (-)NCBIT2T-CHM13v2.0
Prpf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,377,603 - 75,400,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,377,642 - 75,400,275 (+)EnsemblGRCm39 Ensembl
GRCm381175,486,777 - 75,509,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,486,816 - 75,509,449 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,300,279 - 75,322,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,303,285 - 75,325,578 (+)NCBIMGSCv36mm8
Celera1182,995,186 - 83,017,855 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Prpf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,829,778 - 60,852,887 (+)NCBIGRCr8
mRatBN7.21060,331,494 - 60,354,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,331,494 - 60,354,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,978,414 - 65,001,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,483,841 - 64,507,188 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,946,410 - 59,969,757 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,635,239 - 63,658,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,635,219 - 63,658,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,348,558 - 64,371,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,786,225 - 62,830,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,821,711 - 62,844,405 (+)NCBI
Celera1059,359,820 - 59,382,932 (+)NCBICelera
Cytogenetic Map10q24NCBI
Prpf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,499,634 - 1,530,670 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,499,634 - 1,530,670 (+)NCBIChiLan1.0ChiLan1.0
PRPF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,797,882 - 45,827,365 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,797,959 - 45,828,071 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,948,795 - 44,978,151 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,624,977 - 46,654,363 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,624,983 - 46,654,304 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,395,072 - 45,424,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,689,610 - 45,718,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,744,054 - 45,773,421 (-)NCBIUU_Cfam_GSD_1.0
Prpf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,902,077 - 44,936,620 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,780,022 - 7,814,575 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,780,022 - 7,814,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,861,043 - 47,895,190 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,861,041 - 47,895,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,746,647 - 49,777,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRPF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,321,568 - 1,352,775 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,321,416 - 1,352,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,627,886 - 20,660,154 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prpf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,355,993 - 4,393,243 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,356,481 - 4,392,594 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003816849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000063108   ⟹   ENSPPAP00000040194
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,532,579 - 1,565,254 (-)Ensembl
RefSeq Acc Id: XM_003816849   ⟹   XP_003816897
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2199,223,458 - 9,257,176 (-)NCBI
NHGRI_mPanPan11711,189,660 - 11,223,215 (-)NCBI
Mhudiblu_PPA_v0171,635,991 - 1,669,703 (-)NCBI
PanPan1.1171,532,579 - 1,565,254 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003816897 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000040194
  ENSPPAP00000040194.1
Reference Protein Sequences
RefSeq Acc Id: XP_003816897   ⟸   XM_003816849
- UniProtKB: A0A2R9CE78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000040194   ⟸   ENSPPAT00000063108
Protein Domains
MPN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042753 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063108.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.40 UniProtKB/TrEMBL
  3.30.420.230 UniProtKB/TrEMBL
  3.30.43.40 UniProtKB/TrEMBL
  3.90.1570.40 UniProtKB/TrEMBL
  Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
InterPro JAMM/MPN+_dom UniProtKB/TrEMBL
  MPN UniProtKB/TrEMBL
  PRO8NT UniProtKB/TrEMBL
  PROCN UniProtKB/TrEMBL
  PROCT UniProtKB/TrEMBL
  PRP8 UniProtKB/TrEMBL
  PRP8_domainIV UniProtKB/TrEMBL
  Prp8_domainIV_fingers UniProtKB/TrEMBL
  Prp8_domainIV_palm UniProtKB/TrEMBL
  Prp8_U5-snRNA-bd UniProtKB/TrEMBL
  Prp8_U5-snRNA-bd_sf UniProtKB/TrEMBL
  Prp8_U6-snRNA-bd UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RRM_spliceosomal_PrP8 UniProtKB/TrEMBL
KEGG Report pps:100979365 UniProtKB/TrEMBL
NCBI Gene PRPF8 ENTREZGENE
PANTHER PRE-MRNA-PROCESSING-SPLICING FACTOR 8 UniProtKB/TrEMBL
  PTHR11140 UniProtKB/TrEMBL
Pfam JAB UniProtKB/TrEMBL
  PRO8NT UniProtKB/TrEMBL
  PROCN UniProtKB/TrEMBL
  PROCT UniProtKB/TrEMBL
  PRP8_domainIV UniProtKB/TrEMBL
  RRM_4 UniProtKB/TrEMBL
  U5_2-snRNA_bdg UniProtKB/TrEMBL
  U6-snRNA_bdg UniProtKB/TrEMBL
PROSITE MPN UniProtKB/TrEMBL
SMART JAB_MPN UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/TrEMBL
UniProt A0A2R9CE78 ENTREZGENE, UniProtKB/TrEMBL