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ONTOLOGY REPORT - ANNOTATIONS

Term:core mediator complex
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Accession:GO:0070847 term browser browse the term
Definition:A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Synonyms:exact_synonym: C mediator complex;   S mediator complex


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core mediator complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Med1 mediator complex subunit 1 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Med10 mediator complex subunit 10 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 1:33,470,064...33,481,698
Ensembl chr 1:33,470,066...33,475,767 		JBrowse link
G Med11 mediator complex subunit 11 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr10:55,164,322...55,165,940
Ensembl chr10:55,164,326...55,166,533 		JBrowse link
G Med14 mediator complex subunit 14 located_in
part_of		 ISO
IBA		 (PMID:24882805)
GO_REF:0000033		 RGD
GO_Central		 PMID:24882805 GO_REF:0000033 NCBI chr  X:10,036,749...10,127,910
Ensembl chr  X:10,036,805...10,126,240 		JBrowse link
G Med15 mediator complex subunit 15 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr11:83,280,722...83,356,006
Ensembl chr11:83,280,762...83,355,362 		JBrowse link
G Med16 mediator complex subunit 16 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172 		JBrowse link
G Med17 mediator complex subunit 17 located_in
part_of		 ISO
IBA		 (PMID:24882805)
GO_REF:0000033		 RGD
GO_Central		 PMID:24882805 GO_REF:0000033 NCBI chr 8:12,101,594...12,120,592
Ensembl chr 8:12,101,594...12,120,592 		JBrowse link
G Med18 mediator complex subunit 18 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 5:144,663,316...144,668,652
Ensembl chr 5:144,663,252...144,668,635 		JBrowse link
G Med19 mediator complex subunit 19 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 3:69,762,138...69,772,661
Ensembl chr 3:69,762,166...69,772,036 		JBrowse link
G Med20 mediator complex subunit 20 located_in
part_of		 ISO
IEA		 (PMID:24882805)
GO_REF:0000107		 RGD
Ensembl		 PMID:24882805 GO_REF:0000107 NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476 		JBrowse link
G Med21 mediator complex subunit 21 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 4:179,560,509...179,583,811
Ensembl chr 4:179,560,579...179,567,548 		JBrowse link
G Med22 mediator complex subunit 22 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 3:10,233,754...10,238,836
Ensembl chr 3:10,233,754...10,238,836 		JBrowse link
G Med23 mediator complex subunit 23 located_in
part_of		 ISO
IEA		 (PMID:24882805)
GO_REF:0000107		 RGD
Ensembl		 PMID:24882805 GO_REF:0000107 NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463 		JBrowse link
G Med24 mediator complex subunit 24 located_in
part_of		 ISO
IEA		 (PMID:24882805)
GO_REF:0000107		 RGD
Ensembl		 PMID:24882805 GO_REF:0000107 NCBI chr10:83,664,609...83,702,315
Ensembl chr10:83,664,609...83,690,123 		JBrowse link
G Med25 mediator complex subunit 25 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 1:95,359,961...95,375,827
Ensembl chr 1:95,360,284...95,375,877 		JBrowse link
G Med26 mediator complex subunit 26 located_in
part_of		 ISO
IBA		 (PMID:24882805)
GO_REF:0000033		 RGD
GO_Central		 PMID:24882805 GO_REF:0000033 NCBI chr16:17,299,722...17,350,168
Ensembl chr16:17,299,722...17,349,543 		JBrowse link
G Med27 mediator complex subunit 27 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 3:12,629,593...12,803,340
Ensembl chr 3:12,629,603...12,803,339 		JBrowse link
G Med28 mediator complex subunit 28 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr14:65,594,785...65,603,583
Ensembl chr14:65,594,647...65,603,583 		JBrowse link
G Med29 mediator complex subunit 29 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365 		JBrowse link
G Med30 mediator complex subunit 30 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 7:84,004,735...84,026,474
Ensembl chr 7:84,004,722...84,026,595 		JBrowse link
G Med31 mediator complex subunit 31 located_in
part_of		 ISO
IBA		 (PMID:24882805)
GO_REF:0000033		 RGD
GO_Central		 PMID:24882805 GO_REF:0000033 NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326 		JBrowse link
G Med4 mediator complex subunit 4 located_in
part_of		 ISO
IEA
IBA		 (PMID:24882805)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:24882805 GO_REF:0000033 GO_REF:0000107 NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820 		JBrowse link
G Med6 mediator complex subunit 6 located_in
part_of		 ISO
IBA		 (PMID:24882805)
GO_REF:0000033		 RGD
GO_Central		 PMID:24882805 GO_REF:0000033 NCBI chr 6:101,270,410...101,283,929
Ensembl chr 6:101,270,410...101,283,876 		JBrowse link
G Med7 mediator complex subunit 7 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr10:30,842,330...30,857,873
Ensembl chr10:30,842,292...30,859,220 		JBrowse link
G Med8 mediator complex subunit 8 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr 5:131,948,632...131,949,516
Ensembl chr 5:131,943,982...131,950,305 		JBrowse link
G Med9 mediator complex subunit 9 located_in ISO (PMID:24882805) RGD PMID:24882805 NCBI chr10:44,750,667...44,765,464
Ensembl chr10:44,750,698...44,765,464 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20624
    protein-containing complex 6602
      transcription regulator complex 513
        RNA polymerase II transcription regulator complex 244
          core mediator complex 26
Path 2
Term Annotations click to browse term
  cellular_component 20624
    cellular anatomical entity 20386
      intracellular anatomical structure 15010
        intracellular organelle 13391
          intracellular membrane-bounded organelle 11845
            nucleus 7395
              nuclear protein-containing complex 1276
                RNA polymerase II transcription regulator complex 244
                  core mediator complex 26
paths to the root