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ONTOLOGY REPORT - ANNOTATIONS

Term:type 2 mitophagy
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Accession:GO:0061734 term browser browse the term
Definition:The selective autophagy process in which a mitochondrion is degraded by macroautophagy in a process initiated by mitochondrial depolarization (mtDepo) followed by Parkin binding, and ubiquitination of outer membrane proteins, to remove potentially harm-inducing dysfunctional/damaged mitochondria.
Synonyms:exact_synonym: PRKN-mediated mitophagy in response to mitochondrial depolarization;   Park2-mediated mitophagy in response to mitochondrial depolarization;   parkin-mediated mitophagy in response to mitochondrial depolarization


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type 2 mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,099,539...41,122,650
Ensembl chr  X:48,960,430...48,982,642 		JBrowse link
G MFN2 mitofusin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077 		JBrowse link
G OPTN optineurin involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:13,104,335...13,142,725
Ensembl chr10:13,077,345...13,115,773 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (PMID:22020285) ParkinsonsUK-UCL PMID:22020285 NCBI chr 7:90,995,923...91,112,240
Ensembl chr 7:104,500,965...104,568,046 		JBrowse link
G TIMM23 translocase of inner mitochondrial membrane 23 involved_in ISO (PMID:37160114) UniProt PMID:37160114 NCBI chr10:43,123,802...43,157,666 JBrowse link
negative regulation of type 2 mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTRA2 HtrA serine peptidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152 		JBrowse link
G VPS13C vacuolar protein sorting 13 homolog C involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:40,819,512...41,020,644
Ensembl chr15:59,119,001...59,319,619 		JBrowse link
positive regulation of type 2 mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,495,250...27,497,255
Ensembl chr 1:28,532,091...28,542,607 		JBrowse link
G CDC37 cell division cycle 37, HSP90 cochaperone involved_in ISO (PMID:21855797) ParkinsonsUK-UCL PMID:21855797 NCBI chr19:9,942,644...9,955,112
Ensembl chr19:10,606,246...10,618,702 		JBrowse link
G GBA1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (PMID:23707074) ARUK-UCL PMID:23707074 NCBI chr 1:130,579,300...130,589,560
Ensembl chr 1:134,185,385...134,194,851 		JBrowse link
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,099,539...41,122,650
Ensembl chr  X:48,960,430...48,982,642 		JBrowse link
G HK2 hexokinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:74,897,914...74,957,234
Ensembl chr2A:76,400,240...76,460,874 		JBrowse link
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:45,746,228...45,897,250
Ensembl chr  X:53,855,404...54,005,366 		JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:19,454,792...19,463,527
Ensembl chr 1:20,496,356...20,505,281 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:19,583,330...19,601,248
Ensembl chr 1:20,627,693...20,645,560 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G TOMM7 translocase of outer mitochondrial membrane 7 involved_in ISO (PMID:24270810) ParkinsonsUK-UCL PMID:24270810 NCBI chr 7:23,501,438...23,511,321
Ensembl chr 7:23,112,630...23,122,195 		JBrowse link
G VDAC1 voltage dependent anion channel 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:129,375,267...129,408,230
Ensembl chr 5:135,529,173...135,560,005 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16641
    cellular process 16198
      process utilizing autophagic mechanism 526
        autophagy 526
          autophagy of mitochondrion 104
            mitophagy 82
              type 2 mitophagy 17
                negative regulation of type 2 mitophagy 2
                positive regulation of type 2 mitophagy 11
                regulation of type 2 mitophagy + 13
Path 2
Term Annotations click to browse term
  biological_process 16641
    cellular process 16198
      metabolic process 10768
        catabolic process 2487
          autophagy 526
            macroautophagy 322
              mitophagy 82
                type 2 mitophagy 17
                  negative regulation of type 2 mitophagy 2
                  positive regulation of type 2 mitophagy 11
                  regulation of type 2 mitophagy + 13
paths to the root