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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060314 term browser browse the term
Definition:Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.

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regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in ISO (PMID:22067155) RGD
UniProt		 PMID:15628869 PMID:22067155 RGD:7241270 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:22067155) RGD
UniProt		 PMID:15628869 PMID:22067155 RGD:7241270 NCBI chr14:60,027,884...60,042,041
Ensembl chr14:60,027,801...60,044,951
Ensembl chr 6:60,027,801...60,044,951
Ensembl chr24:60,027,801...60,044,951 		JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:22067155) RGD
UniProt		 PMID:15628869 PMID:22067155 RGD:7241270 NCBI chr 6:39,957,012...39,966,562
Ensembl chr 6:39,957,320...39,966,581
Ensembl chr24:39,957,320...39,966,581
Ensembl chr14:39,957,320...39,966,581 		JBrowse link
G DMD dystrophin involved_in ISO (PMID:20080623) BHF-UCL PMID:20080623 NCBI chr  X:29,543,003...32,218,011 JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in ISO (PMID:9461216) BHF-UCL PMID:9461216 NCBI chr 2:55,170,816...55,195,380 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B involved_in ISO (PMID:12837242) BHF-UCL PMID:12837242 NCBI chr14:83,606,511...83,620,289
Ensembl chr14:83,606,454...83,620,205 		JBrowse link
G HRC histidine rich calcium binding protein involved_in ISO (PMID:24125847) BHF-UCL PMID:24125847 NCBI chr 6:42,372,758...42,378,273
Ensembl chr 6:42,372,861...42,377,267 		JBrowse link
G JPH3 junctophilin 3 involved_in ISO (PMID:16809425) UniProt PMID:16809425 NCBI chr 5:72,972,373...73,095,710
Ensembl chr 5:72,972,361...73,094,231 		JBrowse link
G JSRP1 junctional sarcoplasmic reticulum protein 1 acts_upstream_of_or_within ISO (PMID:16638807) MGI PMID:16638807 NCBI chr 6:2,051,075...2,055,842
Ensembl chr 6:2,050,865...2,054,445 		JBrowse link
G PLN phospholamban acts_upstream_of_or_within ISO (PMID:10603936) MGI PMID:10603936 NCBI chr13:55,316,962...55,332,502
Ensembl chr13:55,318,326...55,318,481 		JBrowse link
G SELENON selenoprotein N involved_in ISO (PMID:18713863) UniProt PMID:18713863 NCBI chr20:106,953,286...106,971,249 JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr14:60,027,884...60,042,041
Ensembl chr14:60,027,801...60,044,951
Ensembl chr 6:60,027,801...60,044,951
Ensembl chr24:60,027,801...60,044,951 		JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr 6:39,957,012...39,966,562
Ensembl chr 6:39,957,320...39,966,581
Ensembl chr24:39,957,320...39,966,581
Ensembl chr14:39,957,320...39,966,581 		JBrowse link
G CASQ2 calsequestrin 2 involved_in ISO (PMID:15041652)
PMID:17569730
(PMID:16601229)		 BHF-UCL PMID:15041652 PMID:16601229 PMID:17569730 RGD:2314601 NCBI chr20:17,937,089...18,008,433
Ensembl chr20:17,937,524...18,008,786 		JBrowse link
G CLIC2 chloride intracellular channel 2 involved_in ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738 PMID:15916532 NCBI chr  X:129,564,187...129,606,324
Ensembl chr  X:129,560,658...129,606,438 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr 9:97,305,094...97,317,892 JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel acts_upstream_of_or_within ISO (PMID:17404231) MGI PMID:17404231 NCBI chr 7:36,369,226...36,445,713
Ensembl chr 7:36,369,524...36,443,612 		JBrowse link
G SRI sorcin involved_in ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr21:60,730,164...60,751,054
Ensembl chr21:60,730,051...60,749,678 		JBrowse link
positive regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr14:60,027,884...60,042,041
Ensembl chr14:60,027,801...60,044,951
Ensembl chr 6:60,027,801...60,044,951
Ensembl chr24:60,027,801...60,044,951 		JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr 6:39,957,012...39,966,562
Ensembl chr 6:39,957,320...39,966,581
Ensembl chr24:39,957,320...39,966,581
Ensembl chr14:39,957,320...39,966,581 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr 9:97,305,094...97,317,892 JBrowse link
G JPH2 junctophilin 2 involved_in ISO (PMID:20095964) UniProt PMID:20095964 NCBI chr 2:19,626,035...19,703,589
Ensembl chr 2:19,626,832...19,703,765 		JBrowse link
G TRDN triadin involved_in ISO (PMID:15041652), (PMID:15731460) BHF-UCL PMID:15041652 PMID:15731460 NCBI chr13:50,145,787...50,580,397 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17042
    localization 5425
      regulation of localization 2331
        regulation of sequestering of calcium ion 139
          regulation of release of sequestered calcium ion into cytosol 88
            regulation of ryanodine-sensitive calcium-release channel activity 18
              negative regulation of ryanodine-sensitive calcium-release channel activity 8
              positive regulation of ryanodine-sensitive calcium-release channel activity 6
Path 2
Term Annotations click to browse term
  biological_process 17042
    homeostatic process 1942
      chemical homeostasis 1181
        monoatomic ion homeostasis 661
          intracellular monoatomic ion homeostasis 572
            intracellular monoatomic cation homeostasis 560
              intracellular calcium ion homeostasis 326
                sequestering of calcium ion 141
                  regulation of sequestering of calcium ion 139
                    negative regulation of sequestering of calcium ion 137
                      release of sequestered calcium ion into cytosol 136
                        regulation of release of sequestered calcium ion into cytosol 88
                          regulation of ryanodine-sensitive calcium-release channel activity 18
                            negative regulation of ryanodine-sensitive calcium-release channel activity 8
                            positive regulation of ryanodine-sensitive calcium-release channel activity 6
paths to the root