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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060314 term browser browse the term
Definition:Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.

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regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15628869 GO_REF:0000107 RGD:7241270 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CALM2 calmodulin 2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15628869 GO_REF:0000107 RGD:7241270 NCBI chr14:60,027,884...60,042,041
Ensembl chr14:60,027,801...60,044,951
Ensembl chr 6:60,027,801...60,044,951
Ensembl chr24:60,027,801...60,044,951 		JBrowse link
G CALM3 calmodulin 3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15628869 GO_REF:0000107 RGD:7241270 NCBI chr 6:39,957,012...39,966,562
Ensembl chr 6:39,957,320...39,966,581
Ensembl chr24:39,957,320...39,966,581
Ensembl chr14:39,957,320...39,966,581 		JBrowse link
G DMD dystrophin involved_in ISO (MGI:4420848|PMID:20080623) BHF-UCL PMID:20080623 MGI:4420848 NCBI chr  X:29,543,003...32,218,011 JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in ISO (MGI:1195585|PMID:9461216) BHF-UCL PMID:9461216 MGI:1195585 NCBI chr 2:55,170,816...55,195,380 JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 2:55,170,873...55,194,535 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B involved_in
NOT|involved_in		 IEA
ISO		 (MGI:3836106|PMID:17921453) Ensembl
BHF-UCL		 PMID:17921453 GO_REF:0000107 MGI:3836106 NCBI chr14:83,606,511...83,620,289
Ensembl chr14:83,606,454...83,620,205 		JBrowse link
G HRC histidine rich calcium binding protein involved_in ISO (PMID:24125847) BHF-UCL PMID:24125847 NCBI chr 6:42,372,758...42,378,273
Ensembl chr 6:42,372,861...42,377,267 		JBrowse link
G JPH3 junctophilin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:72,972,373...73,095,710
Ensembl chr 5:72,972,361...73,094,231 		JBrowse link
G JSRP1 junctional sarcoplasmic reticulum protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16638807) TreeGrafter
MGI		 PMID:16638807 GO_REF:0000118 NCBI chr 6:2,051,075...2,055,842
Ensembl chr 6:2,050,865...2,054,445 		JBrowse link
G PLN phospholamban acts_upstream_of_or_within ISO (PMID:10603936) MGI PMID:10603936 NCBI chr13:55,316,962...55,332,502
Ensembl chr13:55,318,326...55,318,481 		JBrowse link
G SELENON selenoprotein N involved_in ISO (PMID:18713863) UniProt PMID:18713863 NCBI chr20:106,953,286...106,971,249 JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CALM2 calmodulin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:60,027,884...60,042,041
Ensembl chr14:60,027,801...60,044,951
Ensembl chr 6:60,027,801...60,044,951
Ensembl chr24:60,027,801...60,044,951 		JBrowse link
G CALM3 calmodulin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:39,957,012...39,966,562
Ensembl chr 6:39,957,320...39,966,581
Ensembl chr24:39,957,320...39,966,581
Ensembl chr14:39,957,320...39,966,581 		JBrowse link
G CASQ2 calsequestrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:17,937,089...18,008,433
Ensembl chr20:17,937,524...18,008,786 		JBrowse link
G CLIC2 chloride intracellular channel 2 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr  X:129,564,187...129,606,324
Ensembl chr  X:129,560,658...129,606,438 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr 9:97,305,094...97,317,892 JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel acts_upstream_of_or_within ISO (PMID:17404231) MGI PMID:17404231 NCBI chr 7:36,369,226...36,445,713
Ensembl chr 7:36,369,524...36,443,612 		JBrowse link
G SRI sorcin involved_in ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr21:60,730,164...60,751,054
Ensembl chr21:60,730,051...60,749,678 		JBrowse link
positive regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CALM2 calmodulin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:60,027,884...60,042,041
Ensembl chr14:60,027,801...60,044,951
Ensembl chr 6:60,027,801...60,044,951
Ensembl chr24:60,027,801...60,044,951 		JBrowse link
G CALM3 calmodulin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:39,957,012...39,966,562
Ensembl chr 6:39,957,320...39,966,581
Ensembl chr24:39,957,320...39,966,581
Ensembl chr14:39,957,320...39,966,581 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr 9:97,305,094...97,317,892 JBrowse link
G JPH2 junctophilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:19,626,035...19,703,589
Ensembl chr 2:19,626,832...19,703,765 		JBrowse link
G TRDN triadin involved_in ISO (PMID:15041652), (PMID:15731460) BHF-UCL PMID:15041652 PMID:15731460 NCBI chr13:50,145,787...50,580,397 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17079
    localization 5433
      regulation of localization 2326
        regulation of sequestering of calcium ion 140
          regulation of release of sequestered calcium ion into cytosol 86
            regulation of ryanodine-sensitive calcium-release channel activity 19
              negative regulation of ryanodine-sensitive calcium-release channel activity 8
              positive regulation of ryanodine-sensitive calcium-release channel activity 6
Path 2
Term Annotations click to browse term
  biological_process 17079
    homeostatic process 1888
      chemical homeostasis 1154
        monoatomic ion homeostasis 651
          intracellular monoatomic ion homeostasis 572
            intracellular monoatomic cation homeostasis 561
              intracellular calcium ion homeostasis 331
                sequestering of calcium ion 142
                  regulation of sequestering of calcium ion 140
                    negative regulation of sequestering of calcium ion 138
                      release of sequestered calcium ion into cytosol 137
                        regulation of release of sequestered calcium ion into cytosol 86
                          regulation of ryanodine-sensitive calcium-release channel activity 19
                            negative regulation of ryanodine-sensitive calcium-release channel activity 8
                            positive regulation of ryanodine-sensitive calcium-release channel activity 6
paths to the root