FKBP1B (FKBP prolyl isomerase 1B)

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Gene: FKBP1B (FKBP prolyl isomerase 1B) Chlorocebus sabaeus

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Symbol:

FKBP1B

Name:

FKBP prolyl isomerase 1B

RGD ID:

18779370

Description:

ENCODES a protein that exhibits cyclic nucleotide binding (ortholog); FK506 binding (ortholog); INVOLVED IN insulin secretion (ortholog); insulin secretion involved in cellular response to glucose stimulus (ortholog); negative regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Cardiac Arrhythmias (ortholog); cardiomyopathy (ortholog); catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN calcium channel complex (inferred); cytoplasm (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

FK506 binding protein 1B; peptidyl-prolyl cis-trans isomerase FKBP1B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	83,606,511 - 83,620,289 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	83,606,454 - 83,620,205 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	28,546,085 - 28,559,863 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiac Arrhythmias (ISO)

cardiomyopathy (ISO)

catecholaminergic polymorphic ventricular tachycardia (ISO)

congestive heart failure (ISO)

Graves' disease (ISO)

Spinal Cord Injuries (ISO)

Ventricular Fibrillation (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA)

insulin secretion (IEA,ISO)

insulin secretion involved in cellular response to glucose stimulus (IEA,ISO)

negative regulation of calcium-mediated signaling (IEA)

negative regulation of heart rate (IEA)

negative regulation of insulin secretion involved in cellular response to glucose stimulus (IEA,ISO)

negative regulation of release of sequestered calcium ion into cytosol (IEA)

neuronal action potential propagation (IEA,ISO)

positive regulation of axon regeneration (ISO)

positive regulation of cytosolic calcium ion concentration (IEA,ISO)

positive regulation of sequestering of calcium ion (IEA)

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (IEA)

regulation of heart rate (IEA,ISO)

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (IEA,ISO)

regulation of ryanodine-sensitive calcium-release channel activity (ISO)

regulation of transcription by RNA polymerase II (IEA)

release of sequestered calcium ion into cytosol (IEA,ISO)

response to glucose (IEA,ISO)

response to hydrogen peroxide (ISO)

response to redox state (IEA)

response to vitamin E (ISO)

smooth muscle contraction (IEA,ISO)

T cell proliferation (IEA,ISO)

Cellular Component

calcium channel complex (IEA)

cytoplasm (IEA)

membrane (IEA)

sarcoplasmic reticulum (IEA)

sarcoplasmic reticulum membrane (IEA)

Z disc (IEA)

Molecular Function

calcium channel inhibitor activity (IEA)

channel regulator activity (IEA)

cyclic nucleotide binding (ISO)

FK506 binding (IEA,ISO)

isomerase activity (IEA)

peptidyl-prolyl cis-trans isomerase activity (IEA)

protein binding (ISO)

RNA polymerase II CTD heptapeptide repeat P3 isomerase activity (IEA)

RNA polymerase II CTD heptapeptide repeat P6 isomerase activity (IEA)

signaling receptor binding (IEA)

transmembrane transporter binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FKBP1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	83,606,511 - 83,620,289 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	83,606,454 - 83,620,205 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	28,546,085 - 28,559,863 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

FKBP1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	24,033,206 - 24,063,681 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	24,049,701 - 24,063,681 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	24,272,611 - 24,286,551 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	24,126,132 - 24,140,055 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	24,184,278 - 24,198,199	NCBI
Celera	2	24,112,915 - 24,126,882 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	24,011,446 - 24,025,414 (+)	NCBI		HuRef
CHM1_1	2	24,201,974 - 24,215,941 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	24,067,904 - 24,098,366 (+)	NCBI		T2T-CHM13v2.0

Fkbp1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	4,883,174 - 4,891,736 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	4,883,174 - 4,891,591 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	4,833,176 - 4,841,573 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	4,833,174 - 4,841,591 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	4,839,980 - 4,848,401 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	4,855,524 - 4,863,925 (-)	NCBI		MGSCv36	mm8
Celera	12	4,764,579 - 4,773,000 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	2.09	NCBI

Fkbp1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	33,551,583 - 33,570,055 (-)	NCBI		GRCr8
mRatBN7.2	6	27,832,128 - 27,850,600 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	27,838,802 - 27,848,653 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	28,131,312 - 28,140,929 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	28,447,216 - 28,456,831 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	27,921,773 - 27,931,386 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	29,975,863 - 29,987,252 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	29,977,797 - 29,987,451 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	39,899,242 - 39,908,337 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	27,309,253 - 27,318,232 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

Fkbp1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	6,263,271 - 6,277,767 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	6,263,271 - 6,274,823 (+)	NCBI	ChiLan1.0	ChiLan1.0

FKBP1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	102,454,794 - 102,469,102 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	102,458,758 - 102,473,066 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	24,047,287 - 24,065,765 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	24,145,893 - 24,162,842 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	24,145,893 - 24,159,082 (+)	Ensembl	panpan1.1		panPan2

FKBP1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	18,534,295 - 18,544,973 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	18,534,741 - 18,544,943 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	18,433,090 - 18,443,766 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	18,809,188 - 18,819,365 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	18,705,120 - 18,715,320 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl	17	18,808,927 - 18,819,419 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	18,545,586 - 18,556,272 (+)	NCBI		UMICH_Zoey_3.1
UU_Cfam_GSD_1.0	17	18,595,511 - 18,606,198 (+)	NCBI		UU_Cfam_GSD_1.0

Fkbp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	62,916,727 - 62,923,563 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	7,916,002 - 7,922,796 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	7,916,002 - 7,922,747 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FKBP1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	114,623,532 - 114,634,628 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	114,623,529 - 114,636,200 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	121,888,309 - 121,899,459 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Fkbp1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	6,382,983 - 6,394,051 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	6,383,003 - 6,394,051 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007971323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007971324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007971325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000006433 ⟹ ENSCSAP00000004637

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	14	83,606,454 - 83,620,205 (-)	Ensembl

RefSeq Acc Id:

XM_007971324 ⟹ XP_007969515

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	83,606,511 - 83,620,286 (-)	NCBI
Vero_WHO_p1.0	NW_023666045	28,546,087 - 28,559,863 (+)	NCBI

Sequence:

show sequence

GCCGCCCCCTTCCCAGTGGCCCCTCCCCGCGCAGGTCCCGACTCCAGCCGCACCTCCTCTGGCT
CTGCAGTGGCGGCGGGGAGGCGAGCCGGAGCGACTGCGGGGCCGGGACCGGAGCAGAGCCGGGG
TCGGGCAGCAGCAGGGACCCCCGGAGGCGGGGCCTGTGGGACCGCTATGGGCGTGGAGATCGAG
ACCATCTCCCCCGGAGACGGAAGGACATTCCCCAAGAAGGGCCAGACGTGTGTGGTGCACTACA
CAGGAATGCTCCAAAATGGGAAGAAATTTGATTCATCCAGAGACAGAAATAAACCTTTCAAGTT
CAGAATTGGCAAACAGGAAGTCATCAAAGGTTTTGAAGAGGGCGCAGCCCAGATGAGCTTGGGG
CAGAGGGCGAAGCTGACCTGCACCCCTGATGTGGCATATGGAGCCACGGGCCACCCCGGTGTCA
TCCCTCCCAATGCCACCCTCATCTTTGACGTGGAGCTGCTCAACTTAGAGTGAAGGCAGGAAGG
AACTCAAGGTGGCTGGAGATGGCTGCTGCTCACCCTCCTAGCCTGCTCTGCCACTGGGACGGCT
CCTCCCGTTTGGGGCTCTTGATCAGTGTGCTAACCTCACTGCCCCATGGCATCATCCATTCTCT
CTGCCCAAGTTGCTCTGTATGTGTTCGTCAGTGTTCATGCGAATCCTTGCTTGAGGAAACTTCG
GTTGCAGATTGAAGCATTTCAGGTTGTGCATTTTGTGTGATGCATGTAGTAGCCTTTCCTGATG
ACAGAACACAGATCTCTTGTTCGCACAATCTACACTGCCTTACCTTCACTTAAGCCACATACAC
AAGGTGCTCAGACATGAAACGTACATGGTGTACACAGAGGGACTTGAGCCAGTTACCTTTGCTG
TCACTTTCTCTCTTATAAATTCTGTTGGCTGCTCACTTAAACAATGTCCTCTTTGGAAATATGT
AAAATAAAGGCTCTGTGCTTGACAAA

hide sequence

RefSeq Acc Id:

XM_007971325 ⟹ XP_007969516

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	83,606,511 - 83,620,289 (-)	NCBI
Vero_WHO_p1.0	NW_023666045	28,546,085 - 28,559,863 (+)	NCBI

Sequence:

show sequence

CCCGCCGCCCCCTTCCCAGTGGCCCCTCCCCGCGCAGGTCCCGACTCCAGCCGCACCTCCTCTG
GCTCTGCAGTGGCGGCGGGGAGGCGAGCCGGAGCGACTGCGGGGCCGGGACCGGAGCAGAGCCG
GGGTCGGGCAGCAGCAGGGACCCCCGGAGGCGGGGCCTGTGGGACCGCTATGGGCGTGGAGATC
GAGACCATCTCCCCCGGAGACGGAAGGACATTCCCCAAGAAGGGCCAGACGTGTGTGGTGCACT
ACACAGGAATGCTCCAAAATGGGAAGAAATTTGATTCATCCAGAGACAGAAATAAACCTTTCAA
GTTCAGAATTGGCAAACAGGAAGTCATCAAAGGTTTTGAAGAGGGCGCAGCCCAGCTGCGTCCT
CTTTCTCCTCTCCCCATCTGCCCCCATCCCTGCTAGATGAGCTTGGGGCAGAGGGCGAAGCTGA
CCTGCACCCCTGATGTGGCATATGGAGCCACGGGCCACCCCGGTGTCATCCCTCCCAATGCCAC
CCTCATCTTTGACGTGGAGCTGCTCAACTTAGAGTGAAGGCAGGAAGGAACTCAAGGTGGCTGG
AGATGGCTGCTGCTCACCCTCCTAGCCTGCTCTGCCACTGGGACGGCTCCTCCCGTTTGGGGCT
CTTGATCAGTGTGCTAACCTCACTGCCCCATGGCATCATCCATTCTCTCTGCCCAAGTTGCTCT
GTATGTGTTCGTCAGTGTTCATGCGAATCCTTGCTTGAGGAAACTTCGGTTGCAGATTGAAGCA
TTTCAGGTTGTGCATTTTGTGTGATGCATGTAGTAGCCTTTCCTGATGACAGAACACAGATCTC
TTGTTCGCACAATCTACACTGCCTTACCTTCACTTAAGCCACATACACAAGGTGCTCAGACATG
AAACGTACATGGTGTACACAGAGGGACTTGAGCCAGTTACCTTTGCTGTCACTTTCTCTCTTAT
AAATTCTGTTGGCTGCTCACTTAAACAATGTCCTCTTTGGAAATATGTAAAATAAAGGCTCTGT
GCTTGACAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007969515	(Get FASTA)	NCBI Sequence Viewer
	XP_007969516	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004637
	ENSCSAP00000004637.1

RefSeq Acc Id:	XP_007969516 ⟸ XM_007971325
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_007969515 ⟸ XM_007971324
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9R7P8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000004637 ⟸ ENSCSAT00000006433

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000008381	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000006433.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.50.40	UniProtKB/TrEMBL
InterPro	FKBP-type_PPIase	UniProtKB/TrEMBL
	PPIase_dom_sf	UniProtKB/TrEMBL
	PPIase_FKBP_dom	UniProtKB/TrEMBL
NCBI Gene	FKBP1B	ENTREZGENE
PANTHER	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE	UniProtKB/TrEMBL
	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B	UniProtKB/TrEMBL
Pfam	FKBP_C	UniProtKB/TrEMBL
PROSITE	FKBP_PPIASE	UniProtKB/TrEMBL
Superfamily-SCOP	FKBP-like	UniProtKB/TrEMBL
UniProt	A0A0D9R7P8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI