Advanced Search (OLGA)

Gene: Fkbp1b (FKBP prolyl isomerase 1B) Chinchilla lanigera

Analyze

Symbol:

Fkbp1b

Name:

FKBP prolyl isomerase 1B

RGD ID:

9015417

Description:

ENCODES a protein that exhibits calcium channel inhibitor activity (ortholog); calcium channel regulator activity (ortholog); cyclic nucleotide binding (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); insulin secretion (ortholog); insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Cardiac Arrhythmias (ortholog); cardiomyopathy (ortholog); catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN calcium channel complex (ortholog); cytoplasm (ortholog); membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

FK506 binding protein 1B; FK506 binding protein 1B, 12.6 kDa; peptidyl-prolyl cis-trans isomerase FKBP1B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	6,263,271 - 6,277,767 (+)	Ensembl
ChiLan1.0	NW_004955469	6,263,271 - 6,274,823 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiac Arrhythmias (ISO)

cardiomyopathy (ISO)

catecholaminergic polymorphic ventricular tachycardia (ISO)

congestive heart failure (ISO)

Graves' disease (ISO)

Spinal Cord Injuries (ISO)

Ventricular Fibrillation (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (ISO)

insulin secretion (ISO)

insulin secretion involved in cellular response to glucose stimulus (ISO)

negative regulation of calcium-mediated signaling (ISO)

negative regulation of heart rate (ISO)

negative regulation of insulin secretion involved in cellular response to glucose stimulus (ISO)

negative regulation of release of sequestered calcium ion into cytosol (ISO)

neuronal action potential propagation (ISO)

positive regulation of axon regeneration (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of sequestering of calcium ion (ISO)

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (ISO)

regulation of heart rate (ISO)

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (ISO)

release of sequestered calcium ion into cytosol (ISO)

response to glucose (ISO)

response to hydrogen peroxide (ISO)

response to redox state (ISO)

response to vitamin E (ISO)

smooth muscle contraction (ISO)

T cell proliferation (ISO)

Cellular Component

calcium channel complex (ISO)

cytoplasm (ISO)

membrane (ISO)

sarcoplasmic reticulum (ISO)

sarcoplasmic reticulum membrane (ISO)

Z disc (ISO)

Molecular Function

calcium channel inhibitor activity (ISO)

calcium channel regulator activity (ISO)

cyclic nucleotide binding (ISO)

FK506 binding (ISO)

peptidyl-prolyl cis-trans isomerase activity (ISO)

protein binding (ISO)

signaling receptor binding (ISO)

transmembrane transporter binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Fkbp1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	6,263,271 - 6,277,767 (+)	Ensembl
ChiLan1.0	NW_004955469	6,263,271 - 6,274,823 (+)	NCBI	ChiLan1.0	ChiLan1.0

FKBP1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	24,033,206 - 24,063,681 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	24,049,701 - 24,063,681 (+)	Ensembl			hg38	GRCh38
GRCh37	2	24,272,611 - 24,286,551 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	24,126,132 - 24,140,055 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	24,184,278 - 24,198,199	NCBI
Celera	2	24,112,915 - 24,126,882 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	24,011,446 - 24,025,414 (+)	NCBI		HuRef
CHM1_1	2	24,201,974 - 24,215,941 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	24,067,904 - 24,098,366 (+)	NCBI		T2T-CHM13v2.0

Fkbp1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	4,883,174 - 4,891,736 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	4,883,174 - 4,891,591 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	4,833,176 - 4,841,573 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	4,833,174 - 4,841,591 (-)	Ensembl			mm10	GRCm38
MGSCv37	12	4,839,980 - 4,848,401 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	4,855,524 - 4,863,925 (-)	NCBI		MGSCv36	mm8
Celera	12	4,764,579 - 4,773,000 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	2.09	NCBI

Fkbp1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	33,551,583 - 33,570,055 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	33,558,517 - 33,568,129 (-)	Ensembl				GRCr8
mRatBN7.2	6	27,832,128 - 27,850,600 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	27,838,802 - 27,848,653 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	28,131,312 - 28,140,929 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	28,447,216 - 28,456,831 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	27,921,773 - 27,931,386 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	29,975,863 - 29,987,252 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	29,977,797 - 29,987,451 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	39,899,242 - 39,908,337 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	6	27,309,253 - 27,318,232 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

FKBP1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	102,454,794 - 102,469,102 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	102,458,758 - 102,473,066 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	24,047,287 - 24,065,765 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	24,145,893 - 24,162,842 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	24,145,893 - 24,159,082 (+)	Ensembl			panPan2	panpan1.1

FKBP1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	18,534,295 - 18,544,973 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	18,534,741 - 18,544,943 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	18,433,090 - 18,443,766 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	18,809,188 - 18,819,365 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	18,705,120 - 18,715,320 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl	17	18,808,927 - 18,819,419 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	18,545,586 - 18,556,272 (+)	NCBI		UMICH_Zoey_3.1
UU_Cfam_GSD_1.0	17	18,595,511 - 18,606,198 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Fkbp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	62,916,727 - 62,923,563 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	7,916,002 - 7,922,796 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	7,916,002 - 7,922,747 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FKBP1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	114,623,532 - 114,634,628 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	114,623,529 - 114,636,200 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	121,888,309 - 121,899,459 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FKBP1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	83,606,511 - 83,620,289 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	83,606,454 - 83,620,205 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	28,546,085 - 28,559,863 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fkbp1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	6,382,983 - 6,394,051 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	6,383,003 - 6,394,051 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005400373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01052376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01028793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01063636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000016411 ⟹ ENSCLAP00000016247

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955469	6,263,271 - 6,277,767 (+)	Ensembl

RefSeq Acc Id:

XM_005400373 ⟹ XP_005400430

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955469	6,263,271 - 6,274,823 (+)	NCBI

Sequence:

show sequence

CTCCCGCCCCGCCCGGCGCCCCGCCCGCGACCCCACCTTTCCGCGCGGCTCCACCCCGCGCCCC
TCGCCGGCGCCGCCCCGCGCAGGTCCCGCTCCTGCCGCACCTCCTCCGGCTCTGCAGAGGCGGC
GGGGAGCGACCGAGCGCCGCGGGGTCGAGCCAGAGCCGAGCCGGGGTCGGGCGCTTCGAGGACC
CCGGAGGCGGGGCCTGTGGGGCCGCGATGGGCGTGGAGATCGAGACCATCTCCCCGGGAGACGG
AAGGACATTCCCCAAGAAGGGCCAGACATGCGTGGTGCACTACACAGGAATGCTCCAAAATGGG
AAGAAATTCGATTCATCCAGAGATAGAAACAAACCTTTCAAGTTCAGAATTGGTAAACAGGAAG
TCATCAAAGGATTTGAAGAGGGTGCAGCCCAGATGAGCTTGGGGCAGAGGGCGAAGCTGACCTG
CACCCCTGACGTGGCATACGGAGCCACGGGCCATCCTGGTGTCATCCCTCCCAATGCCACCCTC
ATCTTTGACGTGGAGCTGCTCAACTTAGAGTGAAGGCAGGAAGGAGCTCGAGGTGGCTGGAGAT
GGCTGCTGCTCGCCCTTCTAGCCTGCTCTGCCACTGGGACGGCTCCTCCTAGTTGGGGCTCTTG
ATCAGTGTGCTCACCTCACTGCCCCACGGCACTACCACTCGCTCTGCCCAAGTTGCTCTGTATG
TGTTCACCATCGGTCTCGCACATCTTAGCTTGAGGAGACTTCGGTTGCAGATTGAAACGTTTCA
GGTTGTGCATATTTGTGTGATGCATGTAGTAGCCATTCCTGGTCACAGAATAGATTTCTTGTTT
GCACAATCTACACTGCCTTACTGTCACTTAAGCCAGACACACAAGGTGCTCAGACATGAGTGTA
CATGGTGTACCGAGGGACTTGAGCCAGTTACCTTTGCTGTCACTTTCCCTTATGAATTCTGTTG
GCTGCTCACTTAATGTCCTCTTTGGAAATAATCTGTGAAATAAAGGCTCTGTGCTTGACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005400430	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000016247
	ENSCLAP00000016247.1

RefSeq Acc Id:	XP_005400430 ⟸ XM_005400373
- UniProtKB:	A0A8C2VP79 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGVEIETISPGDGRTFPKKGQTCVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGA AQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE hide sequence

Ensembl Acc Id:

ENSCLAP00000016247 ⟸ ENSCLAT00000016411

Protein Domains

PPIase FKBP-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011181	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016411	ENTREZGENE
	ENSCLAT00000016411.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.50.40	UniProtKB/TrEMBL
InterPro	FKBP-type_PPIase	UniProtKB/TrEMBL
	PPIase_dom_sf	UniProtKB/TrEMBL
	PPIase_FKBP_dom	UniProtKB/TrEMBL
NCBI Gene	Fkbp1b	ENTREZGENE
PANTHER	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE	UniProtKB/TrEMBL
	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B	UniProtKB/TrEMBL
Pfam	FKBP_C	UniProtKB/TrEMBL
PROSITE	FKBP_PPIASE	UniProtKB/TrEMBL
Superfamily-SCOP	FKBP-like	UniProtKB/TrEMBL
UniProt	A0A8C2VP79	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-11-06	Fkbp1b	FKBP prolyl isomerase 1B		FK506 binding protein 1B	Symbol and/or name change	5135510	APPROVED
2016-08-16	Fkbp1b	FK506 binding protein 1B		FK506 binding protein 1B, 12.6 kDa	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - MGI