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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular pH reduction
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Accession:GO:0051452 term browser browse the term
Definition:Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
Synonyms:exact_synonym: cell pH reduction;   cellular acidification;   reduction of cellular pH;   reduction of pH in cell
 related_synonym: intracellular acidification

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intracellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr89a G protein-coupled receptor 89A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936867:388,801...426,135 JBrowse link
G Slc12a5 solute carrier family 12 member 5 ISO RGD PMID:16420452 RGD:2303953 NCBI chrNW_004936514:6,999,793...7,027,094
Ensembl chrNW_004936514:6,998,044...7,026,767 		JBrowse link
G Tcirg1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23908015) MGI
Ensembl		 PMID:23908015 GO_REF:0000107 NCBI chrNW_004936599:2,070,211...2,079,169
Ensembl chrNW_004936599:2,066,847...2,079,206 		JBrowse link
G Tpcn2 two pore segment channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:1,301,937...1,343,046
Ensembl chrNW_004936599:1,318,169...1,343,106 		JBrowse link
G Ttpa alpha tocopherol transfer protein ISO RGD PMID:22147702 RGD:7247589 NCBI chrNW_004936496:10,409,948...10,466,722
Ensembl chrNW_004936496:10,454,605...10,465,301 		JBrowse link
endosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 acts_upstream_of_or_within ISO (PMID:16107722) MGI PMID:16107722 NCBI chrNW_004936498:6,213,583...6,237,273 JBrowse link
G Faslg Fas ligand ISO RGD PMID:18045865 RGD:2315735 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Rnasek ribonuclease K involved_in ISO (PMID:26212330) UniProt PMID:26212330 NCBI chrNW_004936595:284,313...286,167
Ensembl chrNW_004936595:284,151...286,167 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936567:3,232,628...3,250,596
Ensembl chrNW_004936567:3,225,511...3,250,684 		JBrowse link
lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:7,206,226...7,232,798
Ensembl chrNW_004936502:7,206,172...7,233,912 		JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:41,083,713...41,087,106
Ensembl chrNW_004936469:41,083,738...41,087,087 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936501:11,955,334...11,967,338
Ensembl chrNW_004936501:11,955,184...11,967,436 		JBrowse link
G Cln5 CLN5 intracellular trafficking protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936511:4,283,016...4,291,968
Ensembl chrNW_004936511:4,283,009...4,292,376 		JBrowse link
G Cln6 CLN6 transmembrane ER protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:28,069,058...28,084,607
Ensembl chrNW_004936471:28,070,462...28,084,648 		JBrowse link
G Creg1 cellular repressor of E1A stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) MGI PMID:33966596 NCBI chrNW_004936481:18,523,022...18,531,227 JBrowse link
G Grn granulin precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936541:793,548...800,271
Ensembl chrNW_004936541:793,523...800,217 		JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:377,359...389,121
Ensembl chrNW_004936472:378,173...389,381 		JBrowse link
G Lamp2 lysosomal associated membrane protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:9,584,221...9,622,330
Ensembl chrNW_004936479:9,584,221...9,610,420 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:21,881,692...21,906,564
Ensembl chrNW_004936474:21,881,712...21,906,569 		JBrowse link
G Snapin SNAP associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20920792) Ensembl
MGI		 PMID:20920792 GO_REF:0000107 NCBI chrNW_004936580:3,449,585...3,464,709
Ensembl chrNW_004936580:3,462,987...3,464,214 		JBrowse link
G Tmem106b transmembrane protein 106B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28728022) Ensembl
MGI		 PMID:28728022 GO_REF:0000107 NCBI chrNW_004936761:1,663,099...1,689,580
Ensembl chrNW_004936761:1,662,738...1,685,156 		JBrowse link
G Tmem199 transmembrane protein 199 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:4,512,866...4,517,404
Ensembl chrNW_004936538:4,511,941...4,517,498 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936567:3,232,628...3,250,596
Ensembl chrNW_004936567:3,225,511...3,250,684 		JBrowse link
negative regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
phagosome acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab20 RAB20, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:2,234,826...2,264,613
Ensembl chrNW_004936472:2,234,873...2,264,622 		JBrowse link
G Rab38 RAB38, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936736:1,304,290...1,360,412
Ensembl chrNW_004936736:1,304,185...1,361,221 		JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936551:750,940...778,432
Ensembl chrNW_004936551:746,936...778,432 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936798:297,600...304,929
Ensembl chrNW_004936798:296,066...305,176 		JBrowse link
G Slamf8 SLAM family member 8 acts_upstream_of_or_within ISO (PMID:22593622) MGI PMID:22593622 NCBI chrNW_004936740:776,557...786,182
Ensembl chrNW_004936740:776,455...786,357 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:18,550,489...18,645,470
Ensembl chrNW_004936473:18,550,484...18,645,628 		JBrowse link
G Tcirg1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19549681) Ensembl
MGI		 PMID:19549681 GO_REF:0000107 NCBI chrNW_004936599:2,070,211...2,079,169
Ensembl chrNW_004936599:2,066,847...2,079,206 		JBrowse link
positive regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:17762181 RGD:2300343 NCBI chrNW_004936545:1,788,995...1,795,842
Ensembl chrNW_004936545:1,786,571...1,794,709 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:17762181 RGD:2300343 NCBI chrNW_004936557:6,415,544...6,423,863
Ensembl chrNW_004936557:6,415,547...6,424,711 		JBrowse link
G Ca2 carbonic anhydrase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23881097) MGI
Ensembl
RGD		 PMID:9665810 PMID:23881097 GO_REF:0000107 RGD:1342423 NCBI chrNW_004936544:362,591...379,151
Ensembl chrNW_004936544:362,591...380,223 		JBrowse link
G Ca7 carbonic anhydrase 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23881097) Ensembl
MGI		 PMID:23881097 GO_REF:0000107 NCBI chrNW_004936475:17,112,004...17,120,105
Ensembl chrNW_004936475:17,112,004...17,120,105 		JBrowse link
positive regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube3a ubiquitin protein ligase E3A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:41,187,665...41,290,345
Ensembl chrNW_004936471:41,187,612...41,283,517 		JBrowse link
regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc9a7 solute carrier family 9 member A7 involved_in ISO (PMID:30335141) UniProt PMID:30335141 NCBI chrNW_004936502:12,450,702...12,587,196
Ensembl chrNW_004936502:12,452,720...12,587,192 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:4,518,798...4,595,003
Ensembl chrNW_004936514:4,517,483...4,595,019 		JBrowse link
vacuolar acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936490:17,235,661...17,296,589
Ensembl chrNW_004936490:17,235,661...17,296,633 		JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936558:1,104,627...1,138,487
Ensembl chrNW_004936558:1,103,135...1,134,573 		JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936592:3,039,911...3,083,610
Ensembl chrNW_004936592:3,039,705...3,086,844 		JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936491:15,112,422...15,138,716
Ensembl chrNW_004936491:15,112,321...15,139,525 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936555:4,285,269...4,307,715
Ensembl chrNW_004936555:4,285,269...4,310,858 		JBrowse link
G Clic4 chloride intracellular channel 4 acts_upstream_of_or_within ISO (PMID:19197003) MGI PMID:19197003 NCBI chrNW_004936474:9,664,872...9,711,036 JBrowse link
G Dmxl1 Dmx like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936715:2,013,745...2,177,418
Ensembl chrNW_004936715:2,013,722...2,179,224 		JBrowse link
G Dmxl2 Dmx like 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:13,330,870...13,483,610
Ensembl chrNW_004936471:13,329,622...13,483,937 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11067873), (PMID:18984740)
(PMID:9670047)		 Ensembl
MGI		 PMID:9670047 PMID:11067873 PMID:18984740 GO_REF:0000107 NCBI chrNW_004936569:888,309...895,991
Ensembl chrNW_004936569:887,742...895,977 		JBrowse link
G Tcirg1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936599:2,070,211...2,079,169
Ensembl chrNW_004936599:2,066,847...2,079,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16037
    biological regulation 11269
      regulation of biological quality 3031
        regulation of intracellular pH 78
          intracellular pH reduction 45
            Golgi lumen acidification + 3
            endosomal lumen acidification 4
            negative regulation of cellular pH reduction + 1
            phagosome acidification + 7
            positive regulation of cellular pH reduction + 5
            regulation of cellular pH reduction + 8
            vacuolar acidification + 24
Path 2
Term Annotations click to browse term
  biological_process 16037
    homeostatic process 1838
      chemical homeostasis 1113
        monoatomic ion homeostasis 619
          monoatomic cation homeostasis 605
            regulation of pH 101
              regulation of cellular pH 86
                regulation of intracellular pH 78
                  intracellular pH reduction 45
                    Golgi lumen acidification + 3
                    endosomal lumen acidification 4
                    negative regulation of cellular pH reduction + 1
                    phagosome acidification + 7
                    positive regulation of cellular pH reduction + 5
                    regulation of cellular pH reduction + 8
                    vacuolar acidification + 24
paths to the root