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ONTOLOGY REPORT - ANNOTATIONS

Term:sperm capacitation
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Accession:GO:0048240 term browser browse the term
Definition:A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
Comment:Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract.
Synonyms:related_synonym: sperm activation

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sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr29:7,631,436...7,742,209
Ensembl chr29:7,631,412...7,740,394 		JBrowse link
G BSPH1 binder of sperm protein homolog 1 acts_upstream_of_or_within ISO (PMID:22539676) MGI PMID:22539676 NCBI chr 6:41,234,737...41,253,039 JBrowse link
G BSPH1 binder of sperm protein homolog 1 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 6:41,235,094...41,239,842 JBrowse link
G C2CD6 C2 calcium dependent domain containing 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:34998468)
(PMID:34919125)		 UniProt
MGI		 PMID:34919125 PMID:34998468 NCBI chr10:87,133,453...87,303,521
Ensembl chr10:87,133,461...87,302,735 		JBrowse link
G CABYR calcium binding tyrosine phosphorylation regulated involved_in IEA InterPro GO_REF:0000002 NCBI chr18:56,371,478...56,395,160
Ensembl chr18:56,371,342...56,394,466 		JBrowse link
G CATSPER2 cation channel sperm associated 2 acts_upstream_of_or_within ISO (PMID:14657366) MGI PMID:14657366 NCBI chr26:39,300,273...39,325,846 JBrowse link
G CATSPER3 cation channel sperm associated 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17227845) Ensembl
TreeGrafter
MGI		 PMID:17227845 GO_REF:0000107 GO_REF:0000118 NCBI chr23:37,740,072...37,791,261
Ensembl chr23:37,743,673...37,791,176 		JBrowse link
G CATSPER4 cation channel sperm associated 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17227845) Ensembl
TreeGrafter
MGI		 PMID:17227845 GO_REF:0000107 GO_REF:0000118 NCBI chr20:106,564,858...106,577,383
Ensembl chr20:106,565,284...106,576,779 		JBrowse link
G CATSPERE catsper channel auxiliary subunit epsilon involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr25:81,495,617...81,656,357
Ensembl chr25:81,495,613...81,655,934 		JBrowse link
G CATSPERZ catsper channel auxiliary subunit zeta involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:9,930,186...9,934,024
Ensembl chr 1:9,930,312...9,933,909 		JBrowse link
G CFTR CF transmembrane conductance regulator involved_in ISO (PMID:21976599) UniProt PMID:21976599 NCBI chr21:86,154,313...86,332,436 JBrowse link
G DLD dihydrolipoamide dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15888450) Ensembl
MGI		 PMID:15888450 GO_REF:0000107 NCBI chr21:76,795,573...76,825,504
Ensembl chr21:76,795,592...76,824,923 		JBrowse link
G EFCAB9 EF-hand calcium binding domain 9 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr23:74,360,052...74,369,105
Ensembl chr23:74,360,551...74,368,822 		JBrowse link
G ELSPBP1 epididymal sperm binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:41,251,829...41,273,841
Ensembl chr 6:41,258,674...41,272,077 		JBrowse link
G LOC103228133 ropporin-1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:55,052,992...55,065,866 JBrowse link
G LOC103228163 ropporin-1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23303679) MGI
TreeGrafter		 PMID:23303679 GO_REF:0000118 NCBI chr22:56,858,260...56,882,208 JBrowse link
G LOC103234338 cation channel sperm-associated protein subunit delta involved_in ISO (PMID:21224844) UniProt PMID:21224844 NCBI chr 6:5,371,611...5,425,288 JBrowse link
G LOC103245736 cation channel sperm-associated protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr26:39,349,237...39,378,269
Ensembl chr26:39,350,886...39,368,945 		JBrowse link
G PCSK4 proprotein convertase subtilisin/kexin type 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16371590) Ensembl
MGI		 PMID:16371590 GO_REF:0000107 NCBI chr 6:1,253,729...1,264,114
Ensembl chr 6:1,254,276...1,263,847 		JBrowse link
G PEBP1 phosphatidylethanolamine binding protein 1 acts_upstream_of_or_within ISO (PMID:16183867) MGI PMID:16183867 NCBI chr11:113,469,845...113,479,177 JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha involved_in ISO (PMID:19560455) UniProt PMID:19560455 NCBI chr 6:12,743,752...12,759,155 JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:12,727,643...12,758,915 JBrowse link
G ROPN1L rhophilin associated tail protein 1 like acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23303679) MGI
Ensembl		 PMID:23303679 GO_REF:0000107 NCBI chr 4:9,978,369...9,999,007
Ensembl chr 4:9,978,409...9,999,009 		JBrowse link
G SEMG2 semenogelin 2 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 2:18,600,672...18,624,180 JBrowse link
G SEMG2 semenogelin 2 acts_upstream_of_or_within ISO (PMID:17123940) MGI PMID:17123940
G SEPTIN4 septin 4 acts_upstream_of_or_within ISO (PMID:15737931) MGI PMID:15737931 NCBI chr16:34,863,357...34,887,433 JBrowse link
G SLC22A14 solute carrier family 22 member 14 acts_upstream_of_or_within ISO (PMID:27811987) MGI PMID:27811987 NCBI chr15:1,097,989...1,111,253
Ensembl chr15:1,098,235...1,110,868 		JBrowse link
G SLC26A3 solute carrier family 26 member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:76,682,255...76,739,460
Ensembl chr21:76,681,951...76,721,139 		JBrowse link
G SLC26A6 solute carrier family 26 member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:10,035,676...10,046,274
Ensembl chr22:10,035,478...10,045,304 		JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22228629) MGI
Ensembl		 PMID:22228629 GO_REF:0000107 NCBI chr23:50,365,686...50,373,300
Ensembl chr23:50,365,269...50,372,814 		JBrowse link
negative regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103239650 glycodelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,624,894...2,630,817
Ensembl chr12:2,625,017...2,630,602 		JBrowse link
positive regulation of flagellated sperm motility involved in capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:94,865,480...94,894,331
Ensembl chr13:94,865,936...94,894,315 		JBrowse link
G DEFB1 defensin beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:6,643,753...6,652,209
Ensembl chr 8:6,643,556...6,651,699 		JBrowse link
G IQCF1 IQ motif containing F1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:13,264,183...13,271,409
Ensembl chr22:13,264,197...13,270,856 		JBrowse link
G RNASE9 ribonuclease A family member 9 (inactive) acts_upstream_of_or_within ISO (PMID:24719258) MGI PMID:24719258 NCBI chr29:21,078,437...21,083,863
Ensembl chr29:21,078,799...21,079,425 		JBrowse link
positive regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM7 ADAM metallopeptidase domain 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:22,573,508...22,631,657
Ensembl chr 8:22,574,681...22,633,039 		JBrowse link
G TMPRSS12 transmembrane serine protease 12 involved_in ISO (PMID:35547804) UniProt PMID:35547804 NCBI chr11:47,071,798...47,115,890 JBrowse link
regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103232377 T-complex protein 11 X-linked protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:90,304,397...90,334,177
Ensembl chr  X:90,311,661...90,335,134 		JBrowse link
G TCP11 t-complex 11 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:36,865,236...37,008,100
Ensembl chr17:37,003,819...37,009,908 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17043
    cellular process 16562
      cellular process involved in reproduction in multicellular organism 492
        sperm capacitation 39
          negative regulation of sperm capacitation 1
          positive regulation of flagellated sperm motility involved in capacitation 4
          positive regulation of sperm capacitation 2
          regulation of sperm capacitation + 5
Path 2
Term Annotations click to browse term
  biological_process 17043
    reproductive process 1776
      sexual reproduction 1122
        gamete generation 873
          male gamete generation 683
            spermatogenesis 658
              spermatid differentiation 281
                spermatid development 270
                  sperm capacitation 39
                    negative regulation of sperm capacitation 1
                    positive regulation of flagellated sperm motility involved in capacitation 4
                    positive regulation of sperm capacitation 2
                    regulation of sperm capacitation + 5
paths to the root