SPINK1 (serine peptidase inhibitor Kazal type 1)

Gene: SPINK1 (serine peptidase inhibitor Kazal type 1) Chlorocebus sabaeus

Analyze

Symbol:

SPINK1

Name:

serine peptidase inhibitor Kazal type 1

RGD ID:

18400633

Description:

ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN cellular response to peptide hormone stimulus (ortholog); negative regulation of calcium ion import (ortholog); negative regulation of nitric oxide mediated signal transduction (ortholog); ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); cervical adenocarcinoma (ortholog); Chronic Experimental Pancreatitis (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pancreatic secretory trypsin inhibitor; serine protease inhibitor Kazal-type 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	50,365,686 - 50,373,300 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	50,365,269 - 50,372,814 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	27,392,009 - 27,396,127 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Experimental Pancreatitis (ISO)

cervical adenocarcinoma (ISO)

Chronic Experimental Pancreatitis (ISO)

Chronic Pancreatitis (ISO)

diabetes mellitus (ISO)

Endometrial Neoplasms (ISO)

endometriosis (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Hereditary Pancreatitis (ISO)

Inflammation (ISO)

nephrotic syndrome type 1 (ISO)

Neurodevelopmental Disorders (ISO)

ovary epithelial cancer (ISO)

pancreatic cancer (ISO)

pancreatitis (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

renal cell carcinoma (ISO)

transitional cell carcinoma (ISO)

Tropical Calcific Pancreatitis (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to peptide hormone stimulus (ISO)

negative regulation of calcium ion import (ISO)

negative regulation of nitric oxide mediated signal transduction (ISO)

negative regulation of peptidyl-tyrosine phosphorylation (ISO)

negative regulation of serine-type endopeptidase activity (ISO)

nitric oxide mediated signal transduction (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of epithelial cell proliferation (ISO)

positive regulation of pancreatic juice secretion (ISO)

positive regulation of peptide hormone secretion (ISO)

regulation of acrosome reaction (ISO)

regulation of store-operated calcium entry (ISO)

response to ethanol (ISO)

response to nutrient levels (ISO)

sperm capacitation (ISO)

Cellular Component

extracellular space (ISO)

Molecular Function

peptidase inhibitor activity (ISO)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

SPINK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	50,365,686 - 50,373,300 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	50,365,269 - 50,372,814 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	27,392,009 - 27,396,127 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SPINK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	147,824,582 - 147,839,196 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	147,824,572 - 147,831,671 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	147,204,145 - 147,218,759 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	147,184,339 - 147,191,453 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	147,184,338 - 147,191,453	NCBI
Celera	5	143,286,018 - 143,293,135 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	142,351,294 - 142,358,402 (-)	NCBI		HuRef
CHM1_1	5	146,636,518 - 146,643,635 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	148,360,276 - 148,374,975 (-)	NCBI		T2T-CHM13v2.0

Spink1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	43,861,134 - 43,870,302 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	43,861,147 - 43,870,622 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	43,728,069 - 43,737,237 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	43,728,082 - 43,737,557 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	43,887,723 - 43,896,891 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	43,853,416 - 43,862,528 (-)	NCBI		MGSCv36	mm8
Celera	18	45,096,166 - 45,111,565 (-)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	23.47	NCBI

Spink1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	36,121,626 - 36,133,596 (-)	NCBI		GRCr8
mRatBN7.2	18	35,870,723 - 35,882,693 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	35,824,550 - 35,882,642 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	35,974,739 - 35,986,709 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	36,693,067 - 36,705,037 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	36,070,012 - 36,081,982 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	38,221,919 - 38,242,092 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	38,221,681 - 38,242,119 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	37,878,841 - 37,898,259 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	37,135,503 - 37,148,282 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Cytogenetic Map	18	q11	NCBI

Spink1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	6,371,059 - 6,378,529 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	6,328,672 - 6,378,611 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPINK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	143,077,196 - 143,091,804 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	141,216,747 - 141,231,379 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	143,273,137 - 143,287,745 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	149,282,828 - 149,297,469 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SPINK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	42,112,015 - 42,120,738 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	42,112,016 - 42,120,706 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	39,152,835 - 39,161,514 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	42,566,457 - 42,575,135 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	42,566,457 - 42,575,107 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	39,642,905 - 39,651,567 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	40,452,599 - 40,461,319 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	41,275,547 - 41,284,243 (-)	NCBI		UU_Cfam_GSD_1.0

Spink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	145,400,956 - 145,407,408 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	6,975,044 - 6,981,304 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	6,975,044 - 6,981,304 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	149,071,703 - 149,079,499 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	149,072,652 - 149,079,529 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	155,635,045 - 155,641,908 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Spink1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	7,281,227 - 7,287,791 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	7,281,298 - 7,287,735 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low		12	24
Below cutoff	5	5	19

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008014881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000010228 ⟹ ENSCSAP00000008326

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	23	50,365,269 - 50,372,814 (-)	Ensembl

RefSeq Acc Id:

XM_008014881 ⟹ XP_008013072

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	23	50,365,686 - 50,373,300 (-)	NCBI
Vero_WHO_p1.0	NW_023666034	27,392,009 - 27,396,127 (+)	NCBI

Sequence:

show sequence

TGAAAGAGTAACCCTTTGAGTTAGATGTTATTATTATTTTGATTTCCAGATGAATACACAGAAG
CACAGCAAAAGTGACTCCAACAAGCACCCTCTACTCTAGAATACACGCTTTAGGGAACTGAGTC
CTCTCTCTCTCTTGCTCTCTCTTTCGCTCTCATCTGCCACTCCACCAGCTACTTTAAGCTTTGT
GAATGGGTGATAGAAAAATAGAGAAAAGAGAAAGAAGAATAAGAAATGAAGAGTGGAGGAAAGG
AAGAAAGAATGGAGAGGTTTTATCCTACTTGGAATAAAATTCTTTCTAGTCGCTATCCATACCT
GCTCATCTATCCAGACCTACAGAGTAGAAGGGATCTTTGGGTTCACCTTACAGGGGAGAAAACA
GGCTTCAGAAGGGTATGACTTTCCCCCAACCATTGAGAGAGCGGGATCAAACTAACCACCAGAA
CTATTTTCCTGACAGAATGTTTGCCTTGTATGTTTCAGGCCCACATGGCTCCTTTCACCTTTCT
TACACAGGTGACATTCCCAGAACCTGGAGGCCAGGCTACAACACAGAGTCAATCAATAACTAGG
GAGATCTATGATATAGCCCAGTAGGTGGGGCCTTGCTGTCGTCTGCCATATGACCCTTCCAGTC
CCAGGCTTCTGAAGAGACGTGGTAAGTGCAGTGCAGTTTTCAACTGACCTCTGGACGCAGAATT
TCAGCCATGCAAGTAACAGGCATCTTTCTTCTCAGTGCCTTGGCCCTGTTGAGTCTACCTGGTA
ACACTGGAGCTGACTCCCTGGGAAGAGAGGCCAAATGTTACAATGAACTTACTGGATGCACCAA
GATATACGACCCTGTCTGTGGGACTGATGGAAAAACTTATCCCAATGAATGTGTGCTATGTTTT
GAAAATCAGAAGCGCCAGACTTCTGTCCTCATTCGAAAATCTGGGCCTTGCTGAGAATCAAGGT
TTTGAAATCCCATCAGGTCACTGTGAGGCCTGGCTGGCCTGATTGTTGAATAAATGCATCTGAA
TACTCCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_008013072	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008326.1

RefSeq Acc Id:	XP_008013072 ⟸ XM_008014881
- UniProtKB:	A0A0D9RI87 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000008326 ⟸ ENSCSAT00000010228

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012141	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010228.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.30	UniProtKB/TrEMBL
InterPro	Kazal_dom	UniProtKB/TrEMBL
	Kazal_dom_sf	UniProtKB/TrEMBL
	Prot_inh_Kazal-m	UniProtKB/TrEMBL
KEGG Report	csab:103244754	UniProtKB/TrEMBL
NCBI Gene	SPINK1	ENTREZGENE
PANTHER	SERINE PROTEASE INHIBITOR	UniProtKB/TrEMBL
	SERINE PROTEASE INHIBITOR KAZAL-TYPE 1	UniProtKB/TrEMBL
Pfam	Kazal_1	UniProtKB/TrEMBL
PRINTS	KAZALINHBTR	UniProtKB/TrEMBL
PROSITE	KAZAL_1	UniProtKB/TrEMBL
	KAZAL_2	UniProtKB/TrEMBL
SMART	KAZAL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF100895	UniProtKB/TrEMBL
UniProt	A0A0D9RI87	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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