ADAM7 (ADAM metallopeptidase domain 7) - Rat Genome Database

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Gene: ADAM7 (ADAM metallopeptidase domain 7) Chlorocebus sabaeus
Analyze
Symbol: ADAM7
Name: ADAM metallopeptidase domain 7
RGD ID: 18490625
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN epididymis development (ortholog); epithelial cell morphogenesis (ortholog); positive regulation of flagellated sperm motility (ortholog); ASSOCIATED WITH genetic disease (ortholog); infertility (ortholog); FOUND IN apical part of cell (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1822,573,508 - 22,631,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl822,574,681 - 22,633,039 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605219,542,447 - 19,609,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAM7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1822,573,508 - 22,631,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl822,574,681 - 22,633,039 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605219,542,447 - 19,609,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ADAM7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38824,441,026 - 24,509,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl824,440,930 - 24,526,970 (+)EnsemblGRCh38hg38GRCh38
GRCh37824,298,539 - 24,367,078 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,354,454 - 24,422,171 (+)NCBINCBI36Build 36hg18NCBI36
Build 34824,354,483 - 24,422,163NCBI
Celera823,262,089 - 23,329,678 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef822,843,132 - 22,911,489 (+)NCBIHuRef
CHM1_1824,500,664 - 24,569,228 (+)NCBICHM1_1
T2T-CHM13v2.0824,716,154 - 24,784,481 (+)NCBIT2T-CHM13v2.0
Adam7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,734,785 - 68,771,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,734,785 - 68,771,190 (-)EnsemblGRCm39 Ensembl
GRCm381468,497,336 - 68,533,689 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,497,336 - 68,533,741 (-)EnsemblGRCm38mm10GRCm38
MGSCv371469,115,393 - 69,151,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,450,666 - 67,487,005 (-)NCBIMGSCv36mm8
Celera1466,256,851 - 66,298,230 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.69NCBI
Adam7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81547,009,176 - 47,057,581 (-)NCBIGRCr8
mRatBN7.21542,833,796 - 42,882,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,833,796 - 42,882,201 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1544,698,442 - 44,746,847 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,848,669 - 45,897,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01544,294,050 - 44,342,457 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01549,418,946 - 49,467,174 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1549,418,946 - 49,467,174 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01553,152,057 - 53,200,285 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41548,184,131 - 48,232,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11548,199,910 - 48,248,313 (-)NCBI
Celera1542,467,652 - 42,515,952 (-)NCBICelera
Cytogenetic Map15p11NCBI
Adam7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540347,465,916 - 47,517,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540347,465,916 - 47,521,251 (+)NCBIChiLan1.0ChiLan1.0
ADAM7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,949,998 - 43,018,649 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1818,684,146 - 18,752,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0823,710,208 - 23,778,026 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1820,627,325 - 20,695,009 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl820,627,325 - 20,713,165 (+)Ensemblpanpan1.1panPan2
ADAM7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12532,946,074 - 33,008,142 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2532,926,553 - 33,008,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2533,530,284 - 33,592,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02533,151,429 - 33,214,291 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2533,131,958 - 33,214,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12533,099,596 - 33,162,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02532,956,827 - 33,019,064 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02533,114,757 - 33,177,349 (-)NCBIUU_Cfam_GSD_1.0
Adam7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,798,686 - 10,845,986 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365557,724,565 - 7,770,149 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365557,724,565 - 7,770,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,483,329 - 8,554,869 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1148,484,391 - 8,554,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,524,174 - 9,565,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Adam7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475819,567,659 - 19,630,082 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475819,538,558 - 19,630,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system nervous system
High
Medium
Low 12 1
Below cutoff 6 32

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007961949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000014233   ⟹   ENSCSAP00000012211
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl822,574,681 - 22,633,039 (+)Ensembl
RefSeq Acc Id: XM_007961949   ⟹   XP_007960140
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1822,573,508 - 22,631,657 (+)NCBI
Vero_WHO_p1.0NW_02366605219,542,447 - 19,609,926 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007960140 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012211.1
Reference Protein Sequences
RefSeq Acc Id: XP_007960140   ⟸   XM_007961949
- UniProtKB: A0A0D9RUC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000012211   ⟸   ENSCSAT00000014233


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016187 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014233.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene ADAM7 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 7 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A0D9RUC2 ENTREZGENE, UniProtKB/TrEMBL