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NADPH oxidase complex - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:NADPH oxidase complex
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Accession:GO:0043020 term browser browse the term
Definition:A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.
Synonyms:narrow_synonym: flavocytochrome b558
 related_synonym: respiratory-burst oxidase

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NADPH oxidase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain part_of
located_in		 IDA
IMP
IEA
ISO
IBA		 PMID:8798532
GO_REF:0000104
(PMID:22423966)
(PMID:24739962)
GO_REF:0000033
(PMID:1763037), (PMID:3305576), (PMID:36241643), (PMID:36413210), (PMID:38355798)
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:1763037 PMID:3305576 PMID:22423966 PMID:24739962 PMID:36241643 More... GO_REF:0000033 GO_REF:0000104 GO_REF:0000107, RGD:1580287, RGD:2291907, RGD:2317869 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain part_of IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:24739962)
(PMID:15338276), (PMID:3305576), (PMID:36241643), (PMID:36413210), (PMID:38355798)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:3305576 PMID:15338276 PMID:24739962 PMID:36241643 PMID:36413210 More... GO_REF:0000033 GO_REF:0000107, RGD:1580287, RGD:2291907 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Duox1 dual oxidase 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 part_of IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:2550933), (PMID:38355798), (PMID:8280052)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:2550933 PMID:8280052 PMID:38355798 PMID:12241540 GO_REF:0000033 GO_REF:0000107, RGD:2291907 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 part_of IEA
ISO		 GO_REF:0000107
GO_REF:0000002
(PMID:38355798), (PMID:8280052)		 Ensembl
InterPro
RGD		 PMID:8280052 PMID:38355798 GO_REF:0000002 GO_REF:0000107 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Ncf4 neutrophil cytosolic factor 4 part_of IBA
ISO
IEA		 GO_REF:0000033
(PMID:38355798), (PMID:8280052)
GO_REF:0000002		 GO_Central
RGD
InterPro		 PMID:8280052 PMID:38355798 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:111,705,926...111,723,893
Ensembl chr 7:109,826,020...109,843,389 		JBrowse link
G Nox1 NADPH oxidase 1 part_of IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:16636067)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:16636067 PMID:15322091 GO_REF:0000033 GO_REF:0000107, RGD:1580287 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox3 NADPH oxidase 3 part_of IBA
ISO
IEA		 GO_REF:0000033
(PMID:17140397)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:17140397 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851 		JBrowse link
G Nox4 NADPH oxidase 4 part_of IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:15322091 GO_REF:0000033, RGD:1580287 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Noxa1 NADPH oxidase activator 1 part_of ISO (PMID:16636067) RGD PMID:16636067 NCBI chr 3:7,895,488...7,907,011
Ensembl chr 3:7,895,488...7,905,967 		JBrowse link
G Noxo1 NADPH oxidase organizer 1 part_of ISO
IEA		 (PMID:16636067)
GO_REF:0000107		 RGD
Ensembl		 PMID:16636067 GO_REF:0000107 NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061 		JBrowse link
G Rac1 Rac family small GTPase 1 part_of ISO (PMID:38355798) RGD PMID:38355798 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rac2 Rac family small GTPase 2 part_of IEA
ISO		 GO_REF:0000107
(PMID:38355798)		 Ensembl
RGD		 PMID:38355798 GO_REF:0000107 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:110,116,260...110,128,720 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21366
    protein-containing complex 6834
      membrane protein complex 1452
        plasma membrane protein complex 688
          NADPH oxidase complex 14
Path 2
Term Annotations click to browse term
  cellular_component 21366
    cellular anatomical structure 21071
      membrane 10504
        plasma membrane 6605
          plasma membrane protein complex 688
            NADPH oxidase complex 14
paths to the root