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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:MDA-5 signaling pathway
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Accession:GO:0039530 term browser browse the term
Definition:The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.
Synonyms:exact_synonym: IFIH1 signaling pathway;   MDA-5 signalling pathway;   melanoma differentiation-associated gene 5 signaling pathway
 narrow_synonym: MDA5 signaling pathway

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MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936469:16,721,306...16,778,249
Ensembl chrNW_004936469:16,721,677...16,774,903 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:2,917,978...2,965,336
Ensembl chrNW_004936668:2,950,124...2,962,572
Ensembl chrNW_004936668:2,950,124...2,962,572 		JBrowse link
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,371,400...2,376,608
Ensembl chrNW_004936677:2,371,418...2,376,608 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:16,940,776...16,949,836
Ensembl chrNW_004936490:16,940,540...16,950,085 		JBrowse link
G Riok3 RIO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:2,921,272...2,949,288
Ensembl chrNW_004936550:2,921,227...2,950,164 		JBrowse link
G Tkfc triokinase and FMN cyclase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:1,697,965...1,710,363
Ensembl chrNW_004936581:1,697,947...1,710,738 		JBrowse link
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd17 ankyrin repeat domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936598:2,191,604...2,338,832
Ensembl chrNW_004936598:2,191,735...2,340,453 		JBrowse link
G Ddx60 DExD/H-box helicase 60 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936516:649,217...735,499
Ensembl chrNW_004936516:649,191...731,639 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:16,940,776...16,949,836
Ensembl chrNW_004936490:16,940,540...16,950,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16037
    cellular process 15650
      signal transduction 5694
        intracellular signal transduction 2819
          intracellular receptor signaling pathway 368
            cytoplasmic pattern recognition receptor signaling pathway 176
              MDA-5 signaling pathway 8
                negative regulation of MDA-5 signaling pathway 4
                positive regulation of MDA-5 signaling pathway 3
                regulation of MDA-5 signaling pathway + 6
Path 2
Term Annotations click to browse term
  biological_process 16037
    response to stimulus 8597
      response to biotic stimulus 1501
        response to external biotic stimulus 1456
          response to other organism 1452
            defense response to other organism 1019
              defense response to symbiont 821
                innate immune response 744
                  regulation of innate immune response 417
                    positive regulation of innate immune response 343
                      activation of innate immune response 281
                        innate immune response-activating signaling pathway 262
                          pattern recognition receptor signaling pathway 258
                            cytoplasmic pattern recognition receptor signaling pathway 176
                              MDA-5 signaling pathway 8
                                negative regulation of MDA-5 signaling pathway 4
                                positive regulation of MDA-5 signaling pathway 3
                                regulation of MDA-5 signaling pathway + 6
paths to the root