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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:MDA-5 signaling pathway
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Accession:GO:0039530 term browser browse the term
Definition:The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.
Synonyms:exact_synonym: IFIH1 signaling pathway;   MDA-5 signalling pathway;   melanoma differentiation-associated gene 5 signaling pathway
 narrow_synonym: MDA5 signaling pathway

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MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624732:3,187,791...3,248,795
Ensembl chrNW_004624732:3,187,791...3,250,981 		JBrowse link
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624786:9,239,119...9,243,617
Ensembl chrNW_004624786:9,239,177...9,243,961 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in ISO (PMID:21187438) UniProt PMID:21187438 NCBI chrNW_004624795:1,787,958...1,793,475
Ensembl chrNW_004624795:1,787,958...1,794,692 		JBrowse link
G Riok3 RIO kinase 3 involved_in ISO (PMID:25865883) UniProt PMID:25865883 NCBI chrNW_004624770:8,675,501...8,696,999
Ensembl chrNW_004624770:8,675,294...8,697,620 		JBrowse link
G Tkfc triokinase and FMN cyclase involved_in ISO (PMID:17600090) UniProt PMID:17600090 NCBI chrNW_004624926:862,339...870,936
Ensembl chrNW_004624926:862,339...869,926 		JBrowse link
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd17 ankyrin repeat domain 17 involved_in ISO (PMID:22328336) UniProt PMID:22328336 NCBI chrNW_004624735:34,337,722...34,516,891
Ensembl chrNW_004624735:34,337,835...34,519,559 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in ISO (MGI:4421606|PMID:20080593) UniProt PMID:20080593 MGI:4421606 NCBI chrNW_004624795:1,787,958...1,793,475
Ensembl chrNW_004624795:1,787,958...1,794,692 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    cellular process 14252
      signal transduction 5427
        intracellular receptor signaling pathway 340
          cytoplasmic pattern recognition receptor signaling pathway 151
            MDA-5 signaling pathway 6
              negative regulation of MDA-5 signaling pathway 4
              positive regulation of MDA-5 signaling pathway 2
              regulation of MDA-5 signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8166
      response to biotic stimulus 1361
        response to external biotic stimulus 1317
          response to other organism 1314
            defense response to other organism 906
              defense response to symbiont 802
                innate immune response 664
                  regulation of innate immune response 371
                    positive regulation of innate immune response 309
                      activation of innate immune response 253
                        innate immune response-activating signaling pathway 237
                          pattern recognition receptor signaling pathway 235
                            cytoplasmic pattern recognition receptor signaling pathway 151
                              MDA-5 signaling pathway 6
                                negative regulation of MDA-5 signaling pathway 4
                                positive regulation of MDA-5 signaling pathway 2
                                regulation of MDA-5 signaling pathway + 5
paths to the root