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ONTOLOGY REPORT - ANNOTATIONS

Term:osteoclast development
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Accession:GO:0036035 term browser browse the term
Definition:The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
Synonyms:exact_synonym: osteoclast cell development


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osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA2 annexin A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:39,322,303...39,371,565
Ensembl chr15:57,625,425...57,674,250 		JBrowse link
G ATP6AP1 ATPase H+ transporting accessory protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:143,870,421...143,878,288
Ensembl chr  X:153,740,751...153,748,621 		JBrowse link
G FOXP1 forkhead box P1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:70,893,933...71,523,892
Ensembl chr 3:72,258,456...72,498,173 		JBrowse link
G GPR68 G protein-coupled receptor 68 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:19479052) Ensembl
MGI		 PMID:19479052 GO_REF:0000107 NCBI chr14:71,859,025...71,891,126
Ensembl chr14:91,207,679...91,208,806 		JBrowse link
G LRRK1 leucine rich repeat kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23526378) Ensembl
MGI		 PMID:23526378 GO_REF:0000107 NCBI chr15:79,642,908...79,793,990
Ensembl chr15:98,931,344...99,081,168 		JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22073305) Ensembl
MGI		 PMID:22073305 GO_REF:0000107 NCBI chr17:2,584,349...2,676,928
Ensembl chr17:2,590,007...2,680,994 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23526378) Ensembl
MGI		 PMID:23526378 GO_REF:0000107 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21841309) Ensembl
MGI		 PMID:21841309 GO_REF:0000107 NCBI chr13:23,750,835...23,784,740 JBrowse link
negative regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr 3:135,037,555...135,061,105
Ensembl chr 3:142,478,031...142,512,548 		JBrowse link
G FBN1 fibrillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351 		JBrowse link
G LOC103783591 leukocyte immunoglobulin-like receptor subfamily B member 1 involved_in ISO (PMID:18802077) UniProt PMID:18802077 NCBI chr19:51,561,376...51,578,564 JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chr 9:55,536,627...55,690,472
Ensembl chr 9:67,886,421...68,021,189 		JBrowse link
osteoclast maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAM20C FAM20C golgi associated secretory pathway kinase acts_upstream_of_or_within ISO (PMID:22615579) MGI PMID:22615579 NCBI chr 7:311,468...394,623 JBrowse link
positive regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR68 G protein-coupled receptor 68 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19479052) Ensembl
MGI		 PMID:19479052 GO_REF:0000107 NCBI chr14:71,859,025...71,891,126
Ensembl chr14:91,207,679...91,208,806 		JBrowse link
G NINJ1 ninjurin 1 involved_in ISO (PMID:30700695) UniProt PMID:30700695 NCBI chr 9:64,245,086...64,258,614
Ensembl chr 9:92,311,502...92,324,030 		JBrowse link
G SLC9B2 solute carrier family 9 member B2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18269914) Ensembl
MGI		 PMID:18269914 GO_REF:0000107 NCBI chr 4:95,474,854...95,532,311
Ensembl chr 4:106,100,229...106,155,749 		JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18269914), (PMID:22437732), (PMID:23980096) Ensembl
MGI		 PMID:18269914 PMID:22437732 PMID:23980096 GO_REF:0000107 NCBI chr13:23,750,835...23,784,740 JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in ISO (PMID:14969392) UniProt PMID:14969392 NCBI chr19:32,821,279...32,825,488
Ensembl chr19:41,570,683...41,575,226 		JBrowse link
regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOTCH2 notch receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:82,457,829...82,615,142
Ensembl chr 1:117,538,243...117,612,840 		JBrowse link
G SIGLEC15 sialic acid binding Ig like lectin 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22451653) Ensembl
TreeGrafter
MGI		 PMID:22451653 GO_REF:0000107 GO_REF:0000118 NCBI chr18:39,111,697...39,125,631
Ensembl chr18:42,658,534...42,663,773 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP acts_upstream_of_or_within ISO (PMID:22451653) MGI PMID:22451653 NCBI chr19:32,821,279...32,825,488
Ensembl chr19:41,570,683...41,575,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16644
    developmental process 6645
      cellular developmental process 4465
        cell development 3179
          bone cell development 19
            osteoclast development 19
              negative regulation of osteoclast development 5
              osteoclast maturation 1
              positive regulation of osteoclast development 5
              regulation of osteoclast development + 12
Path 2
Term Annotations click to browse term
  biological_process 16644
    developmental process 6645
      cellular developmental process 4465
        cell differentiation 4464
          cell development 3179
            hemopoiesis 1021
              leukocyte differentiation 657
                myeloid leukocyte differentiation 275
                  osteoclast differentiation 132
                    osteoclast development 19
                      negative regulation of osteoclast development 5
                      osteoclast maturation 1
                      positive regulation of osteoclast development 5
                      regulation of osteoclast development + 12
paths to the root