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ONTOLOGY REPORT - ANNOTATIONS


Term:osteoclast differentiation
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Accession:GO:0030316 term browser browse the term
Definition:The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
Synonyms:exact_synonym: osteoclast cell differentiation



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osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant IEP RGD PMID:19361364 RGD:2315902 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Calcr calcitonin receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:76792|PMID:7664679)
Ensembl
RGD
PMID:7664679 GO_REF:0000107 MGI:76792 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Car2 carbonic anhydrase 2 TAS RGD PMID:9665810 RGD:1342423 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Ccn4 cellular communication network factor 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:5788182|PMID:25864198)
Ensembl
RGD
PMID:25864198 GO_REF:0000107 MGI:5788182 NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248
JBrowse link
G Cd300lf Cd300 molecule-like family member F acts_upstream_of_or_within ISO (MGI:2682475|PMID:14662855) RGD PMID:14662855 MGI:2682475 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex acts_upstream_of_or_within ISO MGI:104798|MGI:1100089|MGI:1857735 (MGI:3525391|PMID:15485831) RGD PMID:15485831 MGI:3525391 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Csf1 colony stimulating factor 1 acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
IBA
(MGI:3836131|PMID:17442941)
(PMID:18606301)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:17442941 PMID:18606301 PMID:12379742 PMID:21873635 GO_REF:0000107 MGI:3836131, RGD:628338, RGD:13792537 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in ISS
ISO
IEA
IBA
GO_REF:0000024
(MGI:4835629|PMID:20504948), (MGI:5294299|PMID:17121910), (MGI:5294540|PMID:18814279)
GO_REF:0000107
PMID:21873635
UniProt
RGD
Ensembl
PMID:17121910 PMID:18814279 PMID:20504948 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:4835629 MGI:5294299 MGI:5294540, RGD:13792537 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1858008 (MGI:3578468|PMID:15866165)
Ensembl
RGD
PMID:15866165 GO_REF:0000107 MGI:3578468 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein involved_in ISO (MGI:3510294|PMID:15452179) RGD PMID:15452179 MGI:3510294 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Efna2 ephrin A2 involved_in IBA
ISO
PMID:21873635
(MGI:5284751|PMID:19299512)
RGD PMID:19299512 PMID:21873635 MGI:5284751, RGD:13792537 NCBI chr 7:9,515,635...9,528,071
Ensembl chr 7:9,516,429...9,527,061
JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (MGI:5284751|PMID:19299512) RGD PMID:19299512 MGI:5284751 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
JBrowse link
G Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 involved_in ISO (MGI:4844210|PMID:20702777) RGD PMID:20702777 MGI:4844210 NCBI chr 9:94,053,650...94,162,212
Ensembl chr 9:94,053,726...94,162,212
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO MGI:1857165 (MGI:5297759|PMID:21841309) RGD PMID:21841309 MGI:5297759 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:18799727) RGD PMID:18799727 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Gab2 GRB2-associated binding protein 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3575591|PMID:15750601)
GO_REF:0000107
(PMID:15750601)
UniProt
RGD
Ensembl
PMID:15750601 GO_REF:0000024 GO_REF:0000107 MGI:3575591 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Glo1 glyoxalase 1 involved_in ISO (MGI:5526937|PMID:18695250) RGD PMID:18695250 MGI:5526937 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gpc3 glypican 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2159355 (MGI:3612305|PMID:15936336)
Ensembl
RGD
PMID:15936336 GO_REF:0000107 MGI:3612305 NCBI chr  X:131,868,983...132,236,837
Ensembl chr  X:131,868,990...132,236,798
JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in ISS
ISO
GO_REF:0000024
(MGI:5750254|PMID:26438360)
UniProt
RGD
PMID:26438360 GO_REF:0000024 MGI:5750254 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:19252502)
Ensembl
RGD
PMID:19252502 GO_REF:0000107 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3029146|PMID:14769860)
Ensembl
RGD
PMID:14769860 GO_REF:0000107 MGI:3029146 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in IEA
ISO
GO_REF:0000107
(MGI:5306313|PMID:15304486)
Ensembl
RGD
PMID:15304486 GO_REF:0000107 MGI:5306313 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mitf melanocyte inducing transcription factor acts_upstream_of_or_within ISO MGI:1856095 (MGI:2180980|PMID:12086670) RGD PMID:12086670 MGI:2180980 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 acts_upstream_of_or_within ISO MGI:2158925 (MGI:5295788|PMID:21982707) RGD PMID:21982707 MGI:5295788 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Oscar osteoclast associated Ig-like receptor acts_upstream_of_or_within ISO MGI:1277211|MGI:5301430|MGI:98725 (MGI:5297759|PMID:21841309)
(PMID:21841309)
RGD PMID:21841309 MGI:5297759 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1856885 (MGI:2654323|PMID:12627228)
RGD PMID:12627228 PMID:21873635 MGI:2654323, RGD:13792537 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
JBrowse link
G Sbno2 strawberry notch homolog 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5551983 (MGI:5522615|PMID:23980096)
RGD PMID:23980096 PMID:21873635 MGI:5522615, RGD:13792537 NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527
JBrowse link
G Snx10 sorting nexin 10 involved_in ISO (MGI:5317512|PMID:22174188) RGD PMID:22174188 MGI:5317512 NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO MGI:1856973|MGI:5496553 (MGI:3829104|PMID:18768394), (MGI:5318178|PMID:22245629), (MGI:5470331|PMID:23166162), (MGI:5488585|PMID:21305608), (MGI:6296816|PMID:23908015) RGD PMID:18768394 PMID:21305608 PMID:22245629 PMID:23166162 PMID:23908015 MGI:3829104 MGI:5318178 MGI:5470331 MGI:5488585 MGI:6296816 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
G Tf transferrin involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO MGI:2179720 (MGI:5297759|PMID:21841309) RGD PMID:21841309 MGI:5297759 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO MGI:1100089|MGI:99484 (MGI:3525391|PMID:15485831) RGD PMID:15485831 MGI:3525391 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A involved_in ISO (PMID:18606301) RGD PMID:18606301 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in
acts_upstream_of_or_within
ISO (PMID:18606301)
(MGI:3575591|PMID:15750601)
MGI:104798|MGI:99484 (MGI:2682475|PMID:14662855), (MGI:3525391|PMID:15485831), (MGI:3836131|PMID:17442941)
RGD PMID:14662855 PMID:15485831 PMID:15750601 PMID:17442941 PMID:18606301 MGI:2682475 MGI:3525391 MGI:3575591 MGI:3836131 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (MGI:2181820|PMID:10421844) RGD PMID:10421844 MGI:2181820 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of_or_within
ISO (PMID:12925681)
(PMID:21841309)
RGD PMID:12925681 PMID:21841309 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp acts_upstream_of_or_within ISO MGI:2179720|MGI:2450834 (MGI:5297759|PMID:21841309)
(PMID:21841309)
RGD PMID:21841309 MGI:5297759 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
multinuclear osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ocstamp osteoclast stimulatory transmembrane protein involved_in ISO (MGI:5426132|PMID:20882308) RGD PMID:20882308 MGI:5426132 NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
JBrowse link
G Oscar osteoclast associated Ig-like receptor acts_upstream_of_or_within ISO (MGI:2178877|PMID:11805147) RGD PMID:11805147 MGI:2178877 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
JBrowse link
G Sbno2 strawberry notch homolog 2 acts_upstream_of_or_within ISO MGI:5551983 (MGI:5522615|PMID:23980096) RGD PMID:23980096 MGI:5522615 NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2178877|PMID:11805147)
RGD PMID:11805147 PMID:21873635 MGI:2178877, RGD:13792537 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
negative regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn18 claudin 18 acts_upstream_of_or_within ISO MGI:5007067 (MGI:5489769|PMID:22437732) RGD PMID:22437732 MGI:5489769 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351
JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (PMID:24039232)
(MGI:5795811|PMID:24039232)
RGD PMID:24039232 MGI:5795811 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO (PMID:29149593)
(MGI:6106664|PMID:29149593)
RGD PMID:29149593 MGI:6106664 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
JBrowse link
G Tjp2 tight junction protein 2 acts_upstream_of_or_within ISO (MGI:5489769|PMID:22437732) RGD PMID:22437732 MGI:5489769 NCBI chr 1:221,709,745...221,838,383
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
negative regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10822112) RGD PMID:10822112 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 involved_in ISO
ISS
(PMID:21403648)
GO_REF:0000024
RGD
UniProt
PMID:21403648 GO_REF:0000024 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:5691608|PMID:25490771) RGD PMID:25490771 MGI:5691608 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Clec2d C-type lectin domain family 2, member D acts_upstream_of_or_within ISO (MGI:2446956|PMID:12374791) RGD PMID:12374791 MGI:2446956 NCBI chr 4:162,216,052...162,239,530
Ensembl chr 4:162,216,572...162,239,527
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2148567|MGI:3041864 (MGI:3578468|PMID:15866165)
Ensembl
RGD
PMID:15866165 GO_REF:0000107 MGI:3578468 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (PMID:24039232)
(MGI:5795811|PMID:24039232)
RGD PMID:24039232 MGI:5795811 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fstl3 follistatin like 3 involved_in ISO (PMID:15574124) RGD PMID:15574124 NCBI chr 7:9,924,670...9,929,195
Ensembl chr 7:9,923,576...9,939,639
JBrowse link
G Gpr137 G protein-coupled receptor 137 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:204,129,636...204,132,622
Ensembl chr 1:204,129,636...204,133,082
JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in IBA
ISO
PMID:21873635
(MGI:6362357|PMID:31173907)
RGD PMID:31173907 PMID:21873635 MGI:6362357, RGD:13792537 NCBI chr17:86,003,630...86,041,841
Ensembl chr17:85,966,921...86,041,835
JBrowse link
G Gpr55 G protein-coupled receptor 55 involved_in ISO (PMID:19805329) RGD PMID:19805329 NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613
JBrowse link
G Ifnb1 interferon beta 1 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) RGD PMID:17442941 MGI:3836131 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) RGD PMID:17442941 MGI:3836131 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (MGI:2675763|PMID:12941478), (MGI:3836131|PMID:17442941) RGD PMID:12941478 PMID:17442941 MGI:2675763 MGI:3836131 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO MGI:102469|MGI:1100089 (MGI:5295788|PMID:21982707) RGD PMID:21982707 MGI:5295788 NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:2386137|PMID:12161749)
Ensembl
RGD
PMID:12161749 GO_REF:0000107 MGI:2386137 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18802077) RGD PMID:18802077 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Lrrc17 leucine rich repeat containing 17 involved_in ISO (MGI:3850892|PMID:19336404) RGD PMID:19336404 MGI:3850892 NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845
JBrowse link
G Mafb MAF bZIP transcription factor B involved_in ISS
ISO
GO_REF:0000024
(MGI:3849531|PMID:19440205)
UniProt
RGD
PMID:19440205 GO_REF:0000024 MGI:3849531 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1100089|MGI:1339753|MGI:97583 (MGI:3689489|PMID:17053831)
Ensembl
RGD
PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) RGD PMID:17442941 MGI:3836131 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97306 (MGI:3689489|PMID:17053831)
Ensembl
RGD
PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pirb paired Ig-like receptor B involved_in ISO (PMID:18802077) RGD PMID:18802077
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
MGI:3045799 (MGI:3040721|PMID:14976225)
GO_REF:0000107
RGD
Ensembl
PMID:14976225 PMID:17540629 GO_REF:0000107 MGI:3040721, RGD:4107086 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Tcta T-cell leukemia translocation altered involved_in ISO (PMID:19560569) RGD PMID:19560569 NCBI chr 8:108,988,588...108,992,324
Ensembl chr 8:108,988,590...108,991,564
JBrowse link
G Tmem178a transmembrane protein 178A involved_in ISS
ISO
IEA
IBA
GO_REF:0000024
(MGI:5706679|PMID:26644563)
GO_REF:0000107
PMID:21873635
UniProt
RGD
Ensembl
PMID:26644563 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5706679, RGD:13792537 NCBI chr 6:14,004,629...14,063,677
Ensembl chr 6:14,004,630...14,063,549
JBrowse link
G Tob2 transducer of ERBB2, 2 acts_upstream_of_or_within ISO MGI:3789484 (MGI:3785228|PMID:18358842) RGD PMID:18358842 MGI:3785228 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B acts_upstream_of_or_within ISO (MGI:5619442|PMID:23149425) RGD PMID:23149425 MGI:5619442 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201
JBrowse link
osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:7961821) RGD PMID:7961821 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:18799727) RGD PMID:18799727 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Lrrk1 leucine-rich repeat kinase 1 acts_upstream_of_or_within ISO MGI:5568128|MGI:98397 (MGI:5564766|PMID:23526378) RGD PMID:23526378 MGI:5564766 NCBI chr 1:119,844,360...119,972,885
Ensembl chr 1:119,845,146...119,979,734
JBrowse link
G Mir34a microRNA 34a acts_upstream_of_or_within_negative_effect ISO (MGI:5613071|PMID:25043055) RGD PMID:25043055 MGI:5613071 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 acts_upstream_of_or_within ISO (MGI:5308511|PMID:22073305) RGD PMID:22073305 MGI:5308511 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2142227 (MGI:5564766|PMID:23526378)
RGD PMID:23526378 PMID:21873635 MGI:5564766, RGD:13792537 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of_or_within ISO (MGI:5297759|PMID:21841309) RGD PMID:21841309 MGI:5297759 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
osteoclast fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd109 CD109 molecule acts_upstream_of_or_within ISO (MGI:5508870|PMID:23593435) RGD PMID:23593435 MGI:5508870 NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194
JBrowse link
G Cd81 Cd81 molecule involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:2663571|PMID:12796480)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:12796480 GO_REF:0000024 GO_REF:0000107 MGI:2663571 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein involved_in
acts_upstream_of_or_within
ISO (MGI:3588832|PMID:16061724), (MGI:5426134|PMID:17164993), (MGI:5426135|PMID:16937266)
(MGI:5522615|PMID:23980096)
RGD PMID:16061724 PMID:16937266 PMID:17164993 PMID:23980096 MGI:3588832 MGI:5426134 MGI:5426135 MGI:5522615 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Sbno2 strawberry notch homolog 2 acts_upstream_of_or_within ISO MGI:5551983 (MGI:5522615|PMID:23980096) RGD PMID:23980096 MGI:5522615 NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527
JBrowse link
G Sh3pxd2a SH3 and PX domains 2A involved_in ISO (PMID:22584907) RGD PMID:22584907 NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166
JBrowse link
G Tcta T-cell leukemia translocation altered involved_in IBA
ISO
PMID:21873635
(PMID:19560569)
RGD PMID:19560569 PMID:21873635 RGD:13792537 NCBI chr 8:108,988,588...108,992,324
Ensembl chr 8:108,988,590...108,991,564
JBrowse link
osteoclast maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fam20c FAM20C, golgi associated secretory pathway kinase acts_upstream_of_or_within ISO MGI:2656539|MGI:5428020 (MGI:5427766|PMID:22615579) RGD PMID:22615579 MGI:5427766 NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543
JBrowse link
positive regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap1 ATPase H+ transporting accessory protein 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5575464|PMID:22467241)
GO_REF:0000024
Ensembl
RGD
CAFA
PMID:22467241 GO_REF:0000024 GO_REF:0000107 MGI:5575464 NCBI chr  X:152,079,954...152,087,034
Ensembl chr  X:152,079,865...152,087,034
JBrowse link
G Gpr68 G protein-coupled receptor 68 acts_upstream_of_or_within ISO MGI:3849457 (MGI:3848292|PMID:19479052) RGD PMID:19479052 MGI:3848292 NCBI chr 6:120,135,620...120,166,089
Ensembl chr 6:120,135,436...120,166,089
JBrowse link
G Ninj1 ninjurin 1 involved_in ISO (MGI:6458683|PMID:30700695) RGD PMID:30700695 MGI:6458683 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
JBrowse link
G Slc9b2 solute carrier family 9 member B2 acts_upstream_of_or_within ISO (MGI:3785147|PMID:18269914) RGD PMID:18269914 MGI:3785147 NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225
JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of_or_within ISO (MGI:3785147|PMID:18269914), (MGI:5489769|PMID:22437732), (MGI:5522615|PMID:23980096) RGD PMID:18269914 PMID:22437732 PMID:23980096 MGI:3785147 MGI:5489769 MGI:5522615 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO (MGI:3653295|PMID:14969392) RGD PMID:14969392 MGI:3653295 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
positive regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl2 ASXL transcriptional regulator 2 acts_upstream_of_or_within ISO (MGI:5514358|PMID:21490954) RGD PMID:21490954 MGI:5514358 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477
JBrowse link
G Car2 carbonic anhydrase 2 IMP RGD PMID:10523502 RGD:1600711 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 IDA RGD PMID:9920817 RGD:2303108 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IDA RGD PMID:9920817 RGD:2303108 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 involved_in ISO (PMID:21403648) RGD PMID:21403648 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Creb1 cAMP responsive element binding protein 1 acts_upstream_of_or_within ISO (MGI:5495340|PMID:23395171) RGD PMID:23395171 MGI:5495340 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Csf1 colony stimulating factor 1 involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:15304486)
MGI:1100089|MGI:1856333 (MGI:3528531|PMID:15657444), (MGI:3689489|PMID:17053831), (MGI:4849322|PMID:21048959), (MGI:893319|PMID:9215625)
GO_REF:0000107
RGD
Ensembl
PMID:9215625 PMID:15304486 PMID:15657444 PMID:17053831 PMID:21048959 GO_REF:0000107 MGI:3528531 MGI:3689489 MGI:4849322 MGI:893319 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:17121910 RGD:2293713 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit acts_upstream_of_or_within ISO (MGI:5495340|PMID:23395171) RGD PMID:23395171 MGI:5495340 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gnas GNAS complex locus acts_upstream_of_or_within ISO MGI:3043361 (MGI:3619837|PMID:15797856) RGD PMID:15797856 MGI:3619837 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:28731198 RGD:13792731 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:16220542) RGD PMID:16220542 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:17888176) RGD PMID:17888176 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A involved_in IEA
ISO
GO_REF:0000107
(PMID:17888176)
Ensembl
RGD
PMID:17888176 GO_REF:0000107 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il20 interleukin 20 acts_upstream_of_or_within ISO (MGI:5296273|PMID:21844205) RGD PMID:21844205 MGI:5296273 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:17888176) RGD PMID:17888176 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Klf10 Kruppel-like factor 10 acts_upstream_of_or_within ISO MGI:3530069 (MGI:3528531|PMID:15657444) RGD PMID:15657444 MGI:3528531 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Notch2 notch receptor 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:3814108|PMID:18710934)
Ensembl
RGD
PMID:18710934 GO_REF:0000107 MGI:3814108 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Ocstamp osteoclast stimulatory transmembrane protein involved_in ISO (MGI:5319606|PMID:18064667) RGD PMID:18064667 MGI:5319606 NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
JBrowse link
G Pou4f1 POU class 4 homeobox 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5825429|PMID:17668438)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17668438 GO_REF:0000024 GO_REF:0000107 MGI:5825429 NCBI chr15:81,255,566...81,260,057
Ensembl chr15:81,257,781...81,259,728
JBrowse link
G Pou4f2 POU class 4 homeobox 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5825429|PMID:17668438)
UniProt
RGD
PMID:17668438 GO_REF:0000024 MGI:5825429 NCBI chr19:29,486,686...29,490,327
Ensembl chr19:29,486,686...29,490,327
JBrowse link
G Ppargc1b PPARG coactivator 1 beta involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Tmem64 transmembrane protein 64 acts_upstream_of_or_within ISO MGI:3880885 (MGI:5495340|PMID:23395171) RGD PMID:23395171 MGI:5495340 NCBI chr 5:28,698,947...28,745,384
Ensembl chr 5:28,698,918...28,745,330
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17888176) RGD PMID:17888176 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of_or_within
involved_in
IMP
ISO
MGI:102469|MGI:1339753|MGI:2158925 (MGI:3528531|PMID:15657444), (MGI:3575849|PMID:15724149), (MGI:3689489|PMID:17053831), (MGI:4849322|PMID:21048959), (MGI:5295788|PMID:21982707)
(PMID:15304486), (PMID:17241109), (PMID:19560569)
RGD PMID:15304486 PMID:15657444 PMID:15724149 PMID:17053831 PMID:17241109 More... MGI:3528531 MGI:3575849 MGI:3689489 MGI:4849322 MGI:5295788, RGD:730134 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:17135271) RGD PMID:17135271 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6294223|PMID:16418779) RGD PMID:16418779 MGI:6294223 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch2 notch receptor 2 involved_in ISO
IEA
ISS
(PMID:29149593)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:29149593 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Siglec15 sialic acid binding Ig-like lectin 15 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1277211 (MGI:5467208|PMID:22451653)
RGD PMID:22451653 PMID:21873635 MGI:5467208, RGD:13792537 NCBI chr18:71,507,773...71,521,722
Ensembl chr18:71,505,399...71,521,881
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp acts_upstream_of_or_within ISO MGI:3646642 (MGI:5467208|PMID:22451653) RGD PMID:22451653 MGI:5467208 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 NAS RGD PMID:10423016 RGD:631800 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO MGI:1857966 (MGI:3584206|PMID:15802266) RGD PMID:15802266 MGI:3584206 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta involved_in ISS
ISO
GO_REF:0000024
(MGI:3849531|PMID:19440205)
UniProt
RGD
PMID:19440205 GO_REF:0000024 MGI:3849531 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO MGI:2148567 (MGI:3584206|PMID:15802266) RGD PMID:15802266 MGI:3584206 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Esrra estrogen related receptor, alpha IMP RGD PMID:12193582 RGD:625668 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:2135670 (MGI:4437389|PMID:20053668) RGD PMID:20053668 MGI:4437389 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Fshb follicle stimulating hormone subunit beta acts_upstream_of_or_within ISO MGI:1857434 (MGI:3692338|PMID:16630814) RGD PMID:16630814 MGI:3692338 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within ISO MGI:2384087 (MGI:3692338|PMID:16630814) RGD PMID:16630814 MGI:3692338 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Mitf melanocyte inducing transcription factor acts_upstream_of_or_within ISO MGI:1856085|MGI:98511 (MGI:3041714|PMID:11930005) RGD PMID:11930005 MGI:3041714 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISS
ISO
GO_REF:0000024
(MGI:3849531|PMID:19440205)
UniProt
RGD
PMID:19440205 GO_REF:0000024 MGI:3849531 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Prxl2a peroxiredoxin like 2A involved_in ISO (PMID:19951071) RGD PMID:19951071 NCBI chr16:16,866,601...16,886,378
Ensembl chr16:16,866,603...16,886,433
JBrowse link
G Rassf2 Ras association domain family member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5314787 (MGI:5314467|PMID:22227519)
Ensembl
RGD
PMID:22227519 GO_REF:0000107 MGI:5314467 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 acts_upstream_of_or_within ISO MGI:104554 (MGI:3041714|PMID:11930005) RGD PMID:11930005 MGI:3041714 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO (MGI:2448204|PMID:12490655) RGD PMID:12490655 MGI:2448204 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of_or_within ISO (MGI:2448204|PMID:12490655), (MGI:5495340|PMID:23395171) RGD PMID:12490655 PMID:23395171 MGI:2448204 MGI:5495340 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B involved_in IBA
ISO
PMID:21873635
(MGI:5619442|PMID:23149425)
RGD PMID:23149425 PMID:21873635 MGI:5619442, RGD:13792537 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201
JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a IDA RGD PMID:10477728 RGD:633299 NCBI chr 7:8,561,015...8,578,243
Ensembl chr 7:8,563,779...8,576,539
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19391
    developmental process 6775
      cellular developmental process 4483
        cell differentiation 4388
          leukocyte differentiation 611
            myeloid leukocyte differentiation 235
              osteoclast differentiation 111
                multinuclear osteoclast differentiation + 9
                negative regulation of osteoclast differentiation + 30
                osteoclast development + 19
                positive regulation of osteoclast differentiation + 32
                regulation of osteoclast differentiation + 73
Path 2
Term Annotations click to browse term
  biological_process 19391
    developmental process 6775
      anatomical structure development 6201
        multicellular organism development 5638
          system development 5307
            immune system development 1096
              hematopoietic or lymphoid organ development 1029
                hemopoiesis 977
                  myeloid cell differentiation 435
                    myeloid leukocyte differentiation 235
                      osteoclast differentiation 111
                        multinuclear osteoclast differentiation + 9
                        negative regulation of osteoclast differentiation + 30
                        osteoclast development + 19
                        positive regulation of osteoclast differentiation + 32
                        regulation of osteoclast differentiation + 73
paths to the root