FBXW7 (F-box and WD repeat domain containing 7)

Gene: FBXW7 (F-box and WD repeat domain containing 7) Pan paniscus

Analyze

Symbol:

FBXW7

Name:

F-box and WD repeat domain containing 7

RGD ID:

11967486

Description:

ENCODES a protein that exhibits cyclin binding (inferred); identical protein binding (inferred); phosphothreonine residue binding (inferred); INVOLVED IN cellular response to UV (ortholog); DNA damage response (ortholog); lung development (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); basal cell carcinoma (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

F-box/WD repeat-containing protein 7

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	150,206,219 - 150,420,227 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	150,563,293 - 150,777,771 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	144,660,676 - 144,874,404 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	156,312,274 - 156,527,649 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	156,312,274 - 156,402,351 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

basal cell carcinoma (ISO)

Breast Neoplasms (ISO)

chronic lymphocytic leukemia (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

developmental delay, hypotonia, and impaired language (ISO)

Endometrial Neoplasms (ISO)

esophageal carcinoma (ISO)

esophagus squamous cell carcinoma (ISO)

gastric adenocarcinoma (ISO)

genetic disease (ISO)

Genomic Instability (ISO)

glioblastoma (ISO)

head and neck squamous cell carcinoma (ISO)

high grade glioma (ISO)

Liver Metastasis (ISO)

lung adenocarcinoma (ISO)

lung squamous cell carcinoma (ISO)

medulloblastoma (ISO)

melanoma (ISO)

Neurodevelopmental Disorders (ISO)

ovarian serous cystadenocarcinoma (ISO)

papillary renal cell carcinoma (ISO)

pervasive developmental disorder (ISO)

skin melanoma (ISO)

Sporadic Papillary Renal Cell Carcinoma (ISO)

T-cell acute lymphoblastic leukemia (ISO)

transitional cell carcinoma (ISO)

uterine cancer (ISO)

uterine carcinosarcoma (ISO)

Uterine Cervical Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to UV (ISO)

DNA damage response (ISO)

lung development (IEA,ISO)

negative regulation of gene expression (IEA)

negative regulation of osteoclast development (IEA)

Notch signaling pathway (IEA,ISO)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (IEA)

positive regulation of proteasomal protein catabolic process (IEA)

positive regulation of protein targeting to mitochondrion (IEA)

positive regulation of protein ubiquitination (IEA)

positive regulation of ubiquitin-dependent protein catabolic process (IEA)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein destabilization (IEA,ISO)

protein stabilization (IEA)

protein ubiquitination (IEA,ISO)

regulation of cell migration involved in sprouting angiogenesis (IEA)

regulation of circadian rhythm (IEA)

regulation of mitophagy (IEA)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IEA)

sister chromatid cohesion (IEA)

vasculogenesis (IEA,ISO)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IEA)

Golgi apparatus (IEA)

membrane (IEA)

mitochondrion (IEA)

nucleolus (IEA)

nucleoplasm (ISO)

nucleus (IEA,ISO)

Parkin-FBXW7-Cul1 ubiquitin ligase complex (IEA)

perinuclear region of cytoplasm (IEA)

protein-containing complex (ISO)

SCF ubiquitin ligase complex (IEA)

Molecular Function

cyclin binding (IEA)

identical protein binding (IEA)

phosphothreonine residue binding (IEA)

protein binding (ISO)

protein-macromolecule adaptor activity (IEA)

ubiquitin protein ligase binding (IEA)

ubiquitin-like ligase-substrate adaptor activity (IEA)

ubiquitin-protein transferase activator activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Notch signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

FBXW7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	150,206,219 - 150,420,227 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	150,563,293 - 150,777,771 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	144,660,676 - 144,874,404 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	156,312,274 - 156,527,649 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	156,312,274 - 156,402,351 (-)	Ensembl	panpan1.1		panPan2

FBXW7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	152,320,544 - 152,536,092 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	152,320,544 - 152,536,092 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	153,241,696 - 153,457,244 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	153,461,860 - 153,675,622 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	153,601,099 - 153,690,635	NCBI
Celera	4	150,566,189 - 150,779,958 (-)	NCBI		Celera
Cytogenetic Map	4	q31.3	NCBI
HuRef	4	148,968,491 - 149,182,492 (-)	NCBI		HuRef
CHM1_1	4	153,220,162 - 153,434,185 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	155,643,699 - 155,859,255 (-)	NCBI		T2T-CHM13v2.0

Fbxw7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	84,721,901 - 84,886,505 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	84,722,575 - 84,886,505 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	84,814,990 - 84,979,198 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	84,815,268 - 84,979,198 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	84,619,499 - 84,783,120 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	85,038,138 - 85,063,561 (+)	NCBI		MGSCv36	mm8
Celera	3	84,827,347 - 84,997,996 (+)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	37.7	NCBI

Fbxw7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	172,447,738 - 172,609,591 (+)	NCBI		GRCr8
mRatBN7.2	2	170,149,706 - 170,311,536 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	170,149,694 - 170,309,941 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	184,230,191 - 184,309,805 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	184,231,260 - 184,309,664 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	203,633,724 - 203,708,120 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	176,675,226 - 176,750,737 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	164,144,641 - 164,303,043 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Fbxw7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955471	6,848,101 - 6,955,881 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955471	6,852,459 - 7,026,590 (-)	NCBI	ChiLan1.0	ChiLan1.0

FBXW7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	50,187,579 - 50,417,188 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	50,189,240 - 50,417,195 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	50,529,850 - 50,761,421 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	50,869,433 - 51,101,086 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	50,870,969 - 50,964,288 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	50,130,239 - 50,363,954 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	50,231,872 - 50,463,188 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	50,542,860 - 50,774,097 (-)	NCBI		UU_Cfam_GSD_1.0

Fbxw7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	40,081,138 - 40,271,734 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936689	2,259,477 - 2,344,764 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936689	2,261,163 - 2,449,951 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXW7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	76,482,844 - 76,699,348 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	76,482,027 - 76,699,354 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FBXW7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	98,894,261 - 99,105,955 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	98,892,504 - 99,106,084 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	78,541,091 - 78,756,369 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxw7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624858	3,775,795 - 3,873,336 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624858	3,778,842 - 3,974,351 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003815890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014344754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034959269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034959270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034959272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000046895 ⟹ ENSPPAP00000024070

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	156,312,274 - 156,402,351 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000046897 ⟹ ENSPPAP00000024072

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	156,312,274 - 156,343,595 (-)	Ensembl

RefSeq Acc Id:

XM_003815890 ⟹ XP_003815938

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	150,206,219 - 150,237,506 (-)	NCBI
NHGRI_mPanPan1	4	150,563,293 - 150,594,578 (-)	NCBI
Mhudiblu_PPA_v0	4	144,660,676 - 144,691,963 (-)	NCBI
PanPan1.1	4	156,312,274 - 156,343,595 (-)	NCBI

Sequence:

show sequence

AGTGCGTTGTGTGCTTACGGGTTCCCTGGAGCGGATCACCATATAATTGATGTGCAGTCTGCAT
TGCTGAATCCTGGACTGCACCATTCTGTGTTCAAGGGAAGATGTAATCTGATCCCTCTGCTGCT
GAGGGAGGAATCTGTTCAGTCAAGGCTTTGACAGGGCATAGTCTCCTCCAATAATCTTCTCCGT
TCTCTCTCATTATTCCCTCGAGTTCTTCTCAGTCAAGCTGCATGTATGTATGTGTGTCCCGAGA
AGCGGTTTGATACTGAGCTGCATTTGCCTTTACTGTGGAGTTTTGTTGCCGGTTCTGCTCCCTA
ATCTTCCTTTTCTGACGTGCCTGAGCATGTCCACATTAGAATCTGTGACATACCTACCTGAAAA
AGGTTTATATTGTCAGAGACTGCCAAGCAGCCGGACACACGGGGGCACAGAATCACTGAAGGGG
AAAAATACAGAAAATATGGGTTTCTACGGCACATTAAAAATGATTTTTTACAAAATGAAAAGAA
AGTTGGACCATGGTTCTGAGGTCCGCTCTTTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGA
ATATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACTTTTGGGGACCTCAGA
GCAGCCAATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCC
AGGAATGGCTAAAAATGTTTCAGAGCTGGAGTGGACCAGAGAAATTGCTTGCTTTAGATGAACT
CATTGATAGTTGTGAACCAACACAAGTAAAACATATGATGCAAGTGATAGAACCCCAGTTTCAA
CGAGACTTCATTTCATTGCTCCCTAAAGAGTTGGCACTCTATGTGCTTTCATTCCTGGAACCCA
AAGACCTGCTACAAGCGGCTCAGACATGTCGCTACTGGAGAATTTTGGCTGAAGACAACCTTCT
CTGGAGAGAGAAATGCAAAGAAGAGGGGATTGATGAACCATTGCACATCAAGAGAAGAAAAGTA
ATAAAACCAGGTTTCATACACAGTCCATGGAAAAGTGCATACATCAGACAGCACAGAATTGATA
CTAACTGGAGGCGAGGAGAACTCAAATCTCCTAAGGTGCTGAAAGGACATGATGATCATGTGAT
CACATGCTTACAGTTTTGTGGTAACCGAATAGTTAGTGGTTCTGATGACAACACTTTAAAAGTT
TGGTCAGCAGTCACAGGCAAATGTCTGAGAACATTAGTGGGACATACAGGTGGAGTATGGTCAT
CACAAATGAGAGACAACATCATCATTAGTGGATCTACAGATCGGACACTCAAAGTGTGGAATGC
AGAGACTGGAGAATGTATACACACCTTATATGGGCATACTTCCACTGTGCGTTGTATGCATCTT
CATGAAAAAAGAGTTGTTAGCGGTTCTCGAGATGCCACTCTTAGGGTTTGGGATATTGAGACAG
GCCAGTGTTTACATGTTTTGATGGGTCATGTTGCAGCAGTCCGCTGTGTTCAATATGATGGCAG
GAGGGTTGTTAGTGGAGCATATGATTTTATGGTAAAGGTGTGGGATCCAGAGACTGAAACCTGT
CTACACACGTTGCAGGGGCATACTAATAGAGTCTATTCATTACAGTTTGATGGTATCCATGTGG
TGAGTGGATCTCTTGATACATCAATCCGTGTTTGGGATGTGGAGACAGGGAATTGCATTCACAC
GTTAACAGGGCACCAGTCGTTAACAAGTGGAATGGAACTCAAAGACAATATTCTTGTCTCTGGG
AATGCAGATTCTACAGTTAAAATCTGGGATATCAAAACAGGACAGTGTTTACAAACATTGCAAG
GTCCCAACAAGCATCAGAGTGCTGTGACCTGTTTACAGTTCAACAAGAACTTTGTAATTACCAG
CTCAGATGATGGAACTGTAAAACTATGGGACTTGAAAACGGGTGAATTTATTCGAAACCTAGTC
ACATTGGAGAGTGGGGGGAGTGGGGGAGTTGTGTGGCGGATCAGAGCCTCAAACACAAAGCTGG
TGTGTGCAGTTGGGAGTCGGAATGGGACTGAAGAAACCAAGCTGCTGGTGCTGGACTTTGATGT
GGACATGAAGTGAAGAGCAGAAAAGATGAATTTGTCCAATTGTGTAGACGATATACTCCCTGCC
CTTCCCCCTGCAAAAAGAAAAAAAGAAAAGAAAAAGAAAAAAATCCCTTGTTCTCAGTGGTGCA
GGATGTTGGCTTGGGGCAACAGATTGAAAAGACCTACAGACTAAGAAGGAAAAGAAGAAGAGAT
GACAAACCATAACTGACAAGAGAGACGTCTGCTGTCTCTTCACATAAAAGGCTTCACTTTTGAC
TGAGGGCAGCTTTGCAAAATGAGACTTTCTAAATCAAACCAGGTGCAATTATTTCTTTATTTTC
TTCTCCAGTGGTCATTGGGCAGTGTTAATGCTGAAACATCATTACAGATTCTGCTAGCCTGTTC
TTTTACCACTGACAGCTAGACACCTAGAAAGGAACTGCAATAACATCAAAACAAGTACTGGTTG
ACTTTCTAATTAGAGAGCATCTGCAACAAAAAGTCATTTTTCTGGAGTGGAAAAGCTTAAAAAA
ATTACTGTGAATTGTTTTTGTACAGTTATCATGAAAAGCTTTTTTTTTTTTTTTTTTTTTGCCA
ACCATTGCCAATGTCAATCAATCACAGTATTAGCCTCTGTTAATCTATTTACTGTTGCTTCCAT
ATACATTCTTCAATGCATATGTTGCTCAAAGGTGGCAAGTTGTCCTGGGTTCTGTGAGTCCTGA
GATGGATTTAATTCTTGATGCTGGTGCTAGAAGTAGGTCTTCAAATATGGGATTGTTGTCCCAC
CCCTGTACTGTACTCCCAGTGGCCAAACTTATTTATGCTGCTAAATGAAAGAAAGAAAAAAGCA
AATTATTTTTTTTTATTTTTTTTTCTGCTGTGACGTTTTAGTCCCAGACTGAATTCCAAATTTG
CTCTAGTTTGGTTATGGAAAAAAGACTTTTTGCCACTGAAACTTGAGCCATCTGTGCCTCTAAG
AGGCTGAGAATGGAAGAGTTTCAGATAATAAAGAGTGAAGTTTGCCTGCAAGTAAAGAATTGAG
AGTGTGTGCAAAGCTTATTTTCTTTTATCTGGGCAAAAATTAAAACACATTCCTTGGAACAGAG
CTATTACTTGCCTGTTCTGTGGAGAAACTTTTCTTTTTGAGGGCTGTGGTGAATGGACGAACGT
ACATCGTAAAACTGACAAAATATTTTAAAAATATATAAAACACAAAATTAAAATAAAGTTGCTG
GTCAGTCTTAGTGTTTTACAGTATTTGGGAAAACAACTGTTACAGTTTTATTGCTCTGAGTAAC
TGACAAAGCAGAAACTATTCAGTTTTTGTAGTAAAGGCGTCACATGCAAACCAACAAAATGAAT
GAAAAAGTCAAATGGTTTGCCTCATTCTCCAAGAGCCACAACTCAAGCTGAACTGTGAAAGTGG
TTTAACACTGTATCCTAGGCGATCTTTTTTTCCTCCTCCTGTTTATTTTTTTGTTTGTTTTATT
TATAGTCTGATTTAAAACAATCAGATTCAAGTTGGTTAATTTTAGTTATGTAACAACCTGACAT
GATGGAGGAAAACAACCTTTAAAGGGATTGTGTCTATGGTTTGATTCACTTAGAAATTTTATTT
TCTTATAACTTAAGTGCAATAAAATGTGTTTTTTCATGTTA

hide sequence

RefSeq Acc Id:

XM_014344754 ⟹ XP_014200240

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	150,206,219 - 150,420,227 (-)	NCBI
NHGRI_mPanPan1	4	150,563,293 - 150,777,771 (-)	NCBI
Mhudiblu_PPA_v0	4	144,660,676 - 144,874,404 (-)	NCBI
PanPan1.1	4	156,312,274 - 156,527,649 (-)	NCBI

Sequence:

show sequence

CCTCTCTCTGGAGTGAGGCGAGAGCCCCGCACAGAGCGAGGGAGACAGCGAGCTGAGCTCCGGG
CGCTGCCGCTGCCGCTGCCGCTGCCGCCGCCGCTGAGAGTGAGAGCGAAGGAGCATCCGAGAGA
TCCAGTCCCCTGCACTGGCCGCCGCCGAGACCTTCGCTCTCCCCTGGGCCAGCGGGAGCCGCGG
CCGCACTCCTTTCCCCCCTCACCTTCCCGGCCGGCAGCGGCGGCTGCACACGCCGGAGCCGGAG
CCCGAGCCGGAGCCCGAGCCCGAGCCGGAGCCCGAGCCGGAGCCGGAGCCGGCGGCTTGGGGGG
CAGGGAGGCGGCTACCACGGGCCGGGAGTGGGTAGCTGCTCCGCGGTGAGAGAACGCTGAGGAG
GCGCCGGAGCTTCTGCCTCGTCCCGTGGGGCGTGGGGCGAGACCCCCAAGGTGTAGGGAGGGGG
GTCCCAGCCGCAGCGACACATGCGGGAGCCGGGAGCGGGGGCGGCGCCGAGCGGAGCCGGCCGG
GTCCCTCGCCTTGCCGCCGACTCGGCCACCCGCCCGGGGCCGTAGCATCTTGCCCCGGAGTGTA
TGAACCGGGGCCCCAACCAAGCTCGGCAACCACCCCCGGCCGGGGGGGCGGGGACCCCGATGTG
AAGCGGCGGCTGGGGCGGCGGAGAGAGCAGGACCGACGCCGCCGTCCTTTCCTCACCTTCCCCC
TCCCCTCAGCCCCCTCCGGGGGTCTTCTCCCTTGGCCAGTCGCCGGCCCCCCGGCTCCTTGGCT
GGACTCCGGGAGGAGTTCCTAGAGCCCCCCTCCCCCGCCCCAGTCCCGAGGGCGGCGGGGCCGG
GGGGGACCCGGGGGCCGGCCGCAGCCTCCACCCAGAGGAAACTTTATAAAAACAAAATCCGGAG
TCTCCCAAACCTGACTGTCCCGGGAGAAGTGGCCCTGGACGGGCAGAAGCCGCAACCTGAAAAG
ACCCAGGAAGAGGAAAAGAGGAGTACCGCGCCGGAGCCTTCCGCAGCTGCCGCCTCAGTCCGAA
GGAGGAAGGGAACCAACCCACTTTCTCGGCGCCGCGGCTCTTCTCTAAAAGTGATTACTTCCTT
AGGATAGATTGCCAGAAGTGGAGTTACTGGGTCAGAGGAATGTGAAAACCTTTGCATCTTCTGA
TAGTCTAGCCAAGGTCCAAGAGGTAGCAAGCTGGCTTTTGGAAATGAATCAGGAACTGCTCTCT
GTGGGCAGCAAAAGACGACGAACTGGAGGCTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAG
ATGAAGAACAGATGAATCGTGTGGTAGAAGAGGAACAGCAACAGCAACTCAGACAACAAGAGGA
GGAGCACACTGCAAGGAATGGTGAAGTTGTTGGAGTAGAACCTAGACCTGGAGGCCAAAATGAT
TCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATTTATTTCGGTAGATGAGGACTCCTCAG
GAAACCAAGAAGAACAAGAGGAAGATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGA
GGAGGAGGAGATGGACCAGGAGAGTGACGATTTTGATCAGTCTGATGATAGTAGCAGAGAAGAT
GAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTGGACCTGCCTGTTCACCAAC
TCTCCTCCCCATTCTATACAAAAACAACAAAAATGAAAAGAAAGTTGGACCATGGTTCTGAGGT
CCGCTCTTTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGAATATACAAGTACCACTGGGCTT
GTACCATGTTCAGCAACACCAACAACTTTTGGGGACCTCAGAGCAGCCAATGGCCAAGGGCAAC
AACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTAAAAATGTTTCA
GAGCTGGAGTGGACCAGAGAAATTGCTTGCTTTAGATGAACTCATTGATAGTTGTGAACCAACA
CAAGTAAAACATATGATGCAAGTGATAGAACCCCAGTTTCAACGAGACTTCATTTCATTGCTCC
CTAAAGAGTTGGCACTCTATGTGCTTTCATTCCTGGAACCCAAAGACCTGCTACAAGCGGCTCA
GACATGTCGCTACTGGAGAATTTTGGCTGAAGACAACCTTCTCTGGAGAGAGAAATGCAAAGAA
GAGGGGATTGATGAACCATTGCACATCAAGAGAAGAAAAGTAATAAAACCAGGTTTCATACACA
GTCCATGGAAAAGTGCATACATCAGACAGCACAGAATTGATACTAACTGGAGGCGAGGAGAACT
CAAATCTCCTAAGGTGCTGAAAGGACATGATGATCATGTGATCACATGCTTACAGTTTTGTGGT
AACCGAATAGTTAGTGGTTCTGATGACAACACTTTAAAAGTTTGGTCAGCAGTCACAGGCAAAT
GTCTGAGAACATTAGTGGGACATACAGGTGGAGTATGGTCATCACAAATGAGAGACAACATCAT
CATTAGTGGATCTACAGATCGGACACTCAAAGTGTGGAATGCAGAGACTGGAGAATGTATACAC
ACCTTATATGGGCATACTTCCACTGTGCGTTGTATGCATCTTCATGAAAAAAGAGTTGTTAGCG
GTTCTCGAGATGCCACTCTTAGGGTTTGGGATATTGAGACAGGCCAGTGTTTACATGTTTTGAT
GGGTCATGTTGCAGCAGTCCGCTGTGTTCAATATGATGGCAGGAGGGTTGTTAGTGGAGCATAT
GATTTTATGGTAAAGGTGTGGGATCCAGAGACTGAAACCTGTCTACACACGTTGCAGGGGCATA
CTAATAGAGTCTATTCATTACAGTTTGATGGTATCCATGTGGTGAGTGGATCTCTTGATACATC
AATCCGTGTTTGGGATGTGGAGACAGGGAATTGCATTCACACGTTAACAGGGCACCAGTCGTTA
ACAAGTGGAATGGAACTCAAAGACAATATTCTTGTCTCTGGGAATGCAGATTCTACAGTTAAAA
TCTGGGATATCAAAACAGGACAGTGTTTACAAACATTGCAAGGTCCCAACAAGCATCAGAGTGC
TGTGACCTGTTTACAGTTCAACAAGAACTTTGTAATTACCAGCTCAGATGATGGAACTGTAAAA
CTATGGGACTTGAAAACGGGTGAATTTATTCGAAACCTAGTCACATTGGAGAGTGGGGGGAGTG
GGGGAGTTGTGTGGCGGATCAGAGCCTCAAACACAAAGCTGGTGTGTGCAGTTGGGAGTCGGAA
TGGGACTGAAGAAACCAAGCTGCTGGTGCTGGACTTTGATGTGGACATGAAGTGAAGAGCAGAA
AAGATGAATTTGTCCAATTGTGTAGACGATATACTCCCTGCCCTTCCCCCTGCAAAAAGAAAAA
AAGAAAAGAAAAAGAAAAAAATCCCTTGTTCTCAGTGGTGCAGGATGTTGGCTTGGGGCAACAG
ATTGAAAAGACCTACAGACTAAGAAGGAAAAGAAGAAGAGATGACAAACCATAACTGACAAGAG
AGACGTCTGCTGTCTCTTCACATAAAAGGCTTCACTTTTGACTGAGGGCAGCTTTGCAAAATGA
GACTTTCTAAATCAAACCAGGTGCAATTATTTCTTTATTTTCTTCTCCAGTGGTCATTGGGCAG
TGTTAATGCTGAAACATCATTACAGATTCTGCTAGCCTGTTCTTTTACCACTGACAGCTAGACA
CCTAGAAAGGAACTGCAATAACATCAAAACAAGTACTGGTTGACTTTCTAATTAGAGAGCATCT
GCAACAAAAAGTCATTTTTCTGGAGTGGAAAAGCTTAAAAAAATTACTGTGAATTGTTTTTGTA
CAGTTATCATGAAAAGCTTTTTTTTTTTTTTTTTTTTTGCCAACCATTGCCAATGTCAATCAAT
CACAGTATTAGCCTCTGTTAATCTATTTACTGTTGCTTCCATATACATTCTTCAATGCATATGT
TGCTCAAAGGTGGCAAGTTGTCCTGGGTTCTGTGAGTCCTGAGATGGATTTAATTCTTGATGCT
GGTGCTAGAAGTAGGTCTTCAAATATGGGATTGTTGTCCCACCCCTGTACTGTACTCCCAGTGG
CCAAACTTATTTATGCTGCTAAATGAAAGAAAGAAAAAAGCAAATTATTTTTTTTTATTTTTTT
TTCTGCTGTGACGTTTTAGTCCCAGACTGAATTCCAAATTTGCTCTAGTTTGGTTATGGAAAAA
AGACTTTTTGCCACTGAAACTTGAGCCATCTGTGCCTCTAAGAGGCTGAGAATGGAAGAGTTTC
AGATAATAAAGAGTGAAGTTTGCCTGCAAGTAAAGAATTGAGAGTGTGTGCAAAGCTTATTTTC
TTTTATCTGGGCAAAAATTAAAACACATTCCTTGGAACAGAGCTATTACTTGCCTGTTCTGTGG
AGAAACTTTTCTTTTTGAGGGCTGTGGTGAATGGACGAACGTACATCGTAAAACTGACAAAATA
TTTTAAAAATATATAAAACACAAAATTAAAATAAAGTTGCTGGTCAGTCTTAGTGTTTTACAGT
ATTTGGGAAAACAACTGTTACAGTTTTATTGCTCTGAGTAACTGACAAAGCAGAAACTATTCAG
TTTTTGTAGTAAAGGCGTCACATGCAAACCAACAAAATGAATGAAAAAGTCAAATGGTTTGCCT
CATTCTCCAAGAGCCACAACTCAAGCTGAACTGTGAAAGTGGTTTAACACTGTATCCTAGGCGA
TCTTTTTTTCCTCCTCCTGTTTATTTTTTTGTTTGTTTTATTTATAGTCTGATTTAAAACAATC
AGATTCAAGTTGGTTAATTTTAGTTATGTAACAACCTGACATGATGGAGGAAAACAACCTTTAA
AGGGATTGTGTCTATGGTTTGATTCACTTAGAAATTTTATTTTCTTATAACTTAAGTGCAATAA
AATGTGTTTTTTCATGTTA

hide sequence

RefSeq Acc Id:

XM_034959270 ⟹ XP_034815161

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	150,206,219 - 150,420,227 (-)	NCBI
NHGRI_mPanPan1	4	150,563,293 - 150,777,019 (-)	NCBI
Mhudiblu_PPA_v0	4	144,660,676 - 144,874,404 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003815938	(Get FASTA)	NCBI Sequence Viewer
	XP_014200240	(Get FASTA)	NCBI Sequence Viewer
	XP_034815161	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000024070.1
	ENSPPAP00000024072
	ENSPPAP00000024072.1

RefSeq Acc Id:	XP_014200240 ⟸ XM_014344754
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9B761 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEP RPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQS DDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSE YTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDEL IDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLL WREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVI TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNA ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGR RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHT LTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS SDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDV DMK hide sequence

RefSeq Acc Id:	XP_003815938 ⟸ XM_003815890
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9B3A1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MCVPRSGLILSCICLYCGVLLPVLLPNLPFLTCLSMSTLESVTYLPEKGLYCQRLPSSRTHGGT ESLKGKNTENMGFYGTLKMIFYKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTT FGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVI EPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHI KRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDD NTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV RCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDP ETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF IRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK hide sequence

RefSeq Acc Id:	XP_034815161 ⟸ XM_034959270
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9B761 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000024072 ⟸ ENSPPAT00000046897

RefSeq Acc Id:

ENSPPAP00000024070 ⟸ ENSPPAT00000046895

Protein Domains

F-box

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000035178	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000046895.1	UniProtKB/TrEMBL
	ENSPPAT00000046897.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1280.50	UniProtKB/TrEMBL
	2.130.10.10	UniProtKB/TrEMBL
InterPro	F-box-like_dom_sf	UniProtKB/TrEMBL
	F-box_dom	UniProtKB/TrEMBL
	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	pps:100982639	UniProtKB/TrEMBL
NCBI Gene	FBXW7	ENTREZGENE
PANTHER	F-BOX/WD REPEAT-CONTAINING PROTEIN 7	UniProtKB/TrEMBL
	PHOSPHOLIPASE A-2-ACTIVATING PROTEIN	UniProtKB/TrEMBL
Pfam	F-box-like	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	FBOX	UniProtKB/TrEMBL
	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	FBOX	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
	SSF81383	UniProtKB/TrEMBL
UniProt	A0A2R9B3A1	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9B761	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)