LRRK1 (leucine rich repeat kinase 1) - Rat Genome Database

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Gene: LRRK1 (leucine rich repeat kinase 1) Pan paniscus
Analyze
Symbol: LRRK1
Name: leucine rich repeat kinase 1
RGD ID: 11741913
Description: ENCODES a protein that exhibits ATP binding (inferred); GTP binding (inferred); identical protein binding (inferred); INVOLVED IN bone resorption (ortholog); intracellular signal transduction (ortholog); negative regulation of peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH chromosome 15q26-qter deletion syndrome (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat serine/threonine-protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01579,642,908 - 79,793,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11598,936,123 - 99,081,168 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1598,931,344 - 99,081,168 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IEA)
mitochondrion  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LRRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01579,642,908 - 79,793,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11598,936,123 - 99,081,168 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1598,931,344 - 99,081,168 (+)Ensemblpanpan1.1panPan2
LRRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815100,919,357 - 101,078,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl15100,919,327 - 101,078,257 (+)EnsemblGRCh38hg38GRCh38
GRCh3715101,459,562 - 101,618,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361599,276,983 - 99,427,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 341599,380,194 - 99,427,834NCBI
Celera1577,872,799 - 78,023,725 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1577,581,355 - 77,732,446 (+)NCBIHuRef
CHM1_115101,300,443 - 101,451,610 (+)NCBICHM1_1
T2T-CHM13v2.01598,673,894 - 98,832,884 (+)NCBIT2T-CHM13v2.0
Lrrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,908,493 - 66,038,089 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl765,876,660 - 66,038,098 (-)EnsemblGRCm39 Ensembl
GRCm38766,258,745 - 66,388,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl766,226,912 - 66,388,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37773,403,631 - 73,533,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,670,181 - 55,799,947 (-)NCBIMGSCv36mm8
MGSCv36766,137,695 - 66,267,291 (-)NCBIMGSCv36mm8
Celera763,712,568 - 63,843,036 (-)NCBICelera
Celera759,723,311 - 59,724,078 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.57NCBI
Lrrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,254,815 - 129,390,217 (-)NCBIGRCr8
mRatBN7.21119,844,360 - 119,972,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,845,146 - 119,979,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1127,837,758 - 127,964,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,009,201 - 135,136,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,819,030 - 127,946,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,166,866 - 127,301,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,166,431 - 127,292,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,248,473 - 128,372,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41120,695,657 - 120,836,324 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11120,773,221 - 120,921,758 (-)NCBI
Celera1112,054,004 - 112,179,350 (-)NCBICelera
Cytogenetic Map1q22NCBI
Lrrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541627,865,784 - 27,988,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541627,860,934 - 27,988,279 (+)NCBIChiLan1.0ChiLan1.0
LRRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1340,003,299 - 40,122,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl340,004,557 - 40,122,320 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha342,692,357 - 42,816,723 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0340,394,683 - 40,519,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl340,377,843 - 40,513,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1339,927,716 - 40,048,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0340,164,544 - 40,288,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0340,366,423 - 40,490,768 (-)NCBIUU_Cfam_GSD_1.0
Lrrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640143,409,510 - 143,562,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364832,771,938 - 2,924,525 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364832,771,939 - 2,922,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1139,494,121 - 139,624,604 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11139,494,126 - 139,624,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21155,637,573 - 155,853,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12919,385,149 - 19,532,440 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2919,386,170 - 19,533,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605927,010,221 - 27,156,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247683,712,049 - 3,848,651 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247683,701,187 - 3,848,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000053809   ⟹   ENSPPAP00000030945
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1598,931,344 - 99,079,916 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053821   ⟹   ENSPPAP00000030957
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1598,931,344 - 99,079,916 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053847   ⟹   ENSPPAP00000030983
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1598,936,123 - 99,081,168 (+)Ensembl
RefSeq Acc Id: XM_034939513   ⟹   XP_034795404
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBI
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBI
Mhudiblu_PPA_v01579,642,908 - 79,793,990 (+)NCBI
RefSeq Acc Id: XM_034939514   ⟹   XP_034795405
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBI
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBI
Mhudiblu_PPA_v01579,644,288 - 79,793,990 (+)NCBI
RefSeq Acc Id: XM_034939517   ⟹   XP_034795408
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21690,563,578 - 90,659,979 (+)NCBI
NHGRI_mPanPan11594,263,723 - 94,360,510 (+)NCBI
Mhudiblu_PPA_v01579,697,492 - 79,793,990 (+)NCBI
RefSeq Acc Id: XM_055098802   ⟹   XP_054954777
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBI
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBI
RefSeq Acc Id: XM_055098803   ⟹   XP_054954778
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21690,508,435 - 90,659,979 (+)NCBI
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBI
RefSeq Acc Id: XM_063596958   ⟹   XP_063453028
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21690,598,305 - 90,659,979 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034795404   ⟸   XM_034939513
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034795405   ⟸   XM_034939514
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034795408   ⟸   XM_034939517
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000030945   ⟸   ENSPPAT00000053809
RefSeq Acc Id: ENSPPAP00000030957   ⟸   ENSPPAT00000053821
RefSeq Acc Id: ENSPPAP00000030983   ⟸   ENSPPAT00000053847
RefSeq Acc Id: XP_054954777   ⟸   XM_055098802
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054954778   ⟸   XM_055098803
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063453028   ⟸   XM_063596958
- Peptide Label: isoform X4
Protein Domains
Protein kinase   Roc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038425 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053809.1 UniProtKB/TrEMBL
  ENSPPAT00000053821.1 UniProtKB/TrEMBL
  ENSPPAT00000053847.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  COR UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  ROC_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene LRRK1 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1 UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  COR UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Roc UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  ROC UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BMN6_PANPA UniProtKB/TrEMBL
  A0A2R9BWQ8_PANPA UniProtKB/TrEMBL