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ONTOLOGY REPORT - ANNOTATIONS

Term:Leydig cell differentiation
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Accession:GO:0033327 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.


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Leydig cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMH anti-Mullerian hormone involved_in ISO (MGI:1195636|PMID:9435237) UniProt PMID:9435237 MGI:1195636 NCBI chr20:56,785,960...56,788,815 JBrowse link
G AR androgen receptor acts_upstream_of_or_within ISO (PMID:19574395) MGI PMID:19574395 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
G CCND1 cyclin D1 ISO RGD PMID:17303663 RGD:2289137 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 ISO RGD PMID:18502897 RGD:4781870 NCBI chr30:37,474,997...37,487,028
Ensembl chr30:37,473,901...37,487,507 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 ISO RGD PMID:18502897 RGD:4781870 NCBI chr28:15,292,959...15,298,896
Ensembl chr28:15,293,106...15,298,852 		JBrowse link
G DHH desert hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17495005)
(PMID:12050120)		 Ensembl
MGI		 PMID:12050120 PMID:17495005 GO_REF:0000107 NCBI chr27:5,490,122...5,497,144
Ensembl chr27:5,490,441...5,494,636 		JBrowse link
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 ISO RGD PMID:12810569 RGD:2302236 NCBI chr  X:45,165,272...45,167,683
Ensembl chr  X:45,165,272...45,167,574 		JBrowse link
G HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 ISO RGD PMID:18502897 RGD:4781870 NCBI chr 1:70,551,013...70,586,364
Ensembl chr 1:70,487,334...70,586,368 		JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO RGD PMID:18502897 RGD:4781870 NCBI chr17:56,552,945...56,561,062
Ensembl chr17:56,552,945...56,561,062 		JBrowse link
G MAP7 microtubule associated protein 7 acts_upstream_of_or_within ISO (PMID:10837026) MGI PMID:10837026 NCBI chr 1:28,933,422...29,101,944
Ensembl chr 1:28,934,761...29,101,896 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 ISO RGD PMID:15149725 RGD:2302287 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778 		JBrowse link
G NKX2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12399445) Ensembl
MGI		 PMID:12399445 GO_REF:0000107
G NR0B1 nuclear receptor subfamily 0 group B member 1 acts_upstream_of_or_within ISO (PMID:15829514)
(PMID:11564714)		 MGI PMID:11564714 PMID:15829514 NCBI chr  X:25,396,527...25,401,587
Ensembl chr  X:25,396,527...25,401,715 		JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 involved_in IEA Ensembl GO_REF:0000107
G PDGFRA platelet derived growth factor receptor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19056881) Ensembl
MGI		 PMID:19056881 GO_REF:0000107 NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278 		JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19056881) Ensembl
MGI		 PMID:19056881 GO_REF:0000107 NCBI chr28:32,025,791...32,081,824
Ensembl chr28:32,026,350...32,081,835 		JBrowse link
G SF1 splicing factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17495005) Ensembl
MGI		 PMID:17495005 GO_REF:0000107 NCBI chr18:52,380,058...52,393,833
Ensembl chr18:52,380,211...52,393,048 		JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19056881) Ensembl
MGI		 PMID:19056881 GO_REF:0000107 NCBI chr 4:21,666,264...21,717,476
Ensembl chr 4:21,660,939...21,715,155 		JBrowse link
G TMF1 TATA element modulatory factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23000399) Ensembl
MGI		 PMID:23000399 GO_REF:0000107 NCBI chr20:22,684,150...22,716,107
Ensembl chr20:22,684,159...22,714,432 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17924
    reproductive process 1752
      developmental process involved in reproduction 1163
        Leydig cell differentiation 19
Path 2
Term Annotations click to browse term
  biological_process 17924
    developmental process 6840
      anatomical structure development 6424
        multicellular organism development 5184
          system development 4514
            reproductive system development 431
              reproductive structure development 426
                gonad development 335
                  male gonad development 207
                    Leydig cell differentiation 19
paths to the root