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ONTOLOGY REPORT - ANNOTATIONS

Term:mitotic centrosome separation
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Accession:GO:0007100 term browser browse the term
Definition:Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


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mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000002
MGI:1932915|MGI:3836423 (PMID:17060449), (PMID:19075002)
GO_REF:0000107		 InterPro
RGD
Ensembl		 PMID:17060449 PMID:19075002 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Kif11 kinesin family member 11 acts_upstream_of_or_within ISO (PMID:12840069) RGD PMID:12840069 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766 		JBrowse link
G Nde1 nudE neurodevelopment protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869 		JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:894678 (PMID:17060449)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:17060449 GO_REF:0000033 GO_REF:0000107 NCBI chr10:53,505,628...53,582,025
Ensembl chr10:53,516,491...53,570,907 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (PMID:24107630) RGD PMID:24107630 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
positive regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsfl1c NSFL1 cofactor involved_in ISO UniProtKB:Q14CS0 (PMID:23649807) RGD PMID:23649807 NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870 		JBrowse link
G Ranbp1 RAN binding protein 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:12840069)		 GO_Central
RGD		 PMID:12840069 GO_REF:0000033 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838 		JBrowse link
G Ranbp1l1 RAN binding protein 1 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:64,646,634...64,647,446
Ensembl chr11:64,646,726...64,647,337 		JBrowse link
G Ubxn2b UBX domain protein 2B involved_in ISO UniProtKB:Q9UNZ2 (PMID:23649807) RGD PMID:23649807 NCBI chr 5:19,303,634...19,333,181
Ensembl chr 5:19,303,682...19,326,849 		JBrowse link
regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep85 centrosomal protein 85 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr 5:146,356,571...146,404,155
Ensembl chr 5:146,356,576...146,404,060 		JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO
ISS		 (PMID:15311285)
GO_REF:0000024		 RGD
UniProt		 PMID:15311285 GO_REF:0000024 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Kif11 kinesin family member 11 involved_in ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766 		JBrowse link
G Map9 microtubule-associated protein 9 involved_in ISO (PMID:16049101) RGD PMID:16049101 NCBI chr 2:167,708,661...167,743,927
Ensembl chr 2:167,708,765...167,740,736 		JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      cell cycle process 1309
        centrosome separation 15
          mitotic centrosome separation 13
            negative regulation of mitotic centrosome separation 0
            positive regulation of mitotic centrosome separation 4
            regulation of mitotic centrosome separation + 9
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      cellular component organization or biogenesis 7178
        cellular component organization 6924
          organelle organization 3702
            cytoskeleton organization 1548
              microtubule cytoskeleton organization 683
                microtubule organizing center organization 161
                  centrosome cycle 146
                    centrosome separation 15
                      mitotic centrosome separation 13
                        negative regulation of mitotic centrosome separation 0
                        positive regulation of mitotic centrosome separation 4
                        regulation of mitotic centrosome separation + 9
paths to the root