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ONTOLOGY REPORT - ANNOTATIONS


Term:centrosome separation
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Accession:GO:0051299 term browser browse the term
Definition:The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


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centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cntrob centrobin, centriole duplication and spindle assembly protein involved_in IBA
ISO
PMID:21873635
(PMID:16275750)
RGD PMID:16275750, PMID:21873635 RGD:13792537 NCBI chr10:55,901,929...55,927,121
Ensembl chr10:55,901,901...55,924,158
JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:18086858) RGD PMID:18086858 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1932915|MGI:3836423 (MGI:3697244|PMID:17060449), (MGI:3835913|PMID:19075002)
Ensembl
RGD
PMID:17060449 PMID:19075002 GO_REF:0000107 MGI:3697244 MGI:3835913 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Kif11 kinesin family member 11 acts_upstream_of_or_within ISO (MGI:2671632|PMID:12840069) RGD PMID:12840069 MGI:2671632 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Nde1 nudE neurodevelopment protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:860,513...904,624
Ensembl chr10:860,521...896,938
JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:894678 (MGI:3697244|PMID:17060449)
RGD PMID:17060449, PMID:21873635 MGI:3697244, RGD:13792537 NCBI chr10:55,398,919...55,456,654
Ensembl chr10:55,411,901...55,444,861
JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (PMID:24107630) RGD PMID:24107630 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
positive regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsfl1c NSFL1 cofactor involved_in ISO UniProtKB:Q14CS0 (PMID:23649807) RGD PMID:23649807 NCBI chr 3:146,980,923...147,005,478
Ensembl chr 3:146,980,923...147,005,439
JBrowse link
G Ranbp1 RAN binding protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2671632|PMID:12840069)
RGD PMID:12840069, PMID:21873635 MGI:2671632, RGD:13792537 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Ubxn2b UBX domain protein 2B involved_in ISO UniProtKB:Q9UNZ2 (PMID:23649807) RGD PMID:23649807 NCBI chr 5:19,285,368...19,314,199
Ensembl chr 5:19,284,548...19,311,088
JBrowse link
regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep85 centrosomal protein 85 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr 5:152,359,693...152,406,530
Ensembl chr 5:152,359,700...152,406,518
JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO
ISS
(PMID:15311285)
GO_REF:0000024
RGD
UniProt
PMID:15311285 GO_REF:0000024 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Kif11 kinesin family member 11 involved_in ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Map9 microtubule-associated protein 9 involved_in ISO (PMID:16049101) RGD PMID:16049101 NCBI chr 2:181,331,426...181,367,245
Ensembl chr 2:181,331,464...181,367,244
JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      cell cycle process 1174
        centrosome separation 13
          mitotic centrosome separation + 12
Path 2
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      cellular component organization or biogenesis 6721
        cellular component organization 6481
          organelle organization 4060
            cytoskeleton organization 1453
              microtubule cytoskeleton organization 639
                microtubule organizing center organization 150
                  centrosome cycle 137
                    centrosome separation 13
                      mitotic centrosome separation + 12
paths to the root