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ONTOLOGY REPORT - ANNOTATIONS

Term:centrosome separation
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Accession:GO:0051299 term browser browse the term
Definition:The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


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centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cntrob centrobin, centriole duplication and spindle assembly protein involved_in IBA
ISO		 PMID:21873635
(PMID:16275750)		 RGD PMID:16275750 PMID:21873635 RGD:13792537 NCBI chr10:54,022,523...54,047,793
Ensembl chr10:54,022,852...54,044,849 		JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:18086858) RGD PMID:18086858 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1932915|MGI:3836423 (MGI:3697244|PMID:17060449), (MGI:3835913|PMID:19075002)
GO_REF:0000107
GO_REF:0000002		 RGD
Ensembl
InterPro		 PMID:17060449 PMID:19075002 GO_REF:0000002 GO_REF:0000107 MGI:3697244 MGI:3835913 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Kif11 kinesin family member 11 acts_upstream_of_or_within ISO (MGI:2671632|PMID:12840069) RGD PMID:12840069 MGI:2671632 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766 		JBrowse link
G Nde1 nudE neurodevelopment protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869 		JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
MGI:894678 (MGI:3697244|PMID:17060449)		 Ensembl
RGD		 PMID:17060449 PMID:21873635 GO_REF:0000107 MGI:3697244, RGD:13792537 NCBI chr10:53,505,628...53,582,025
Ensembl chr10:53,516,491...53,570,907 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (PMID:24107630) RGD PMID:24107630 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
positive regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsfl1c NSFL1 cofactor involved_in ISO UniProtKB:Q14CS0 (PMID:23649807) RGD PMID:23649807 NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870 		JBrowse link
G Ranbp1 RAN binding protein 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2671632|PMID:12840069)		 RGD PMID:12840069 PMID:21873635 MGI:2671632, RGD:13792537 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838 		JBrowse link
G Ranbp1l1 RAN binding protein 1 like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:64,646,634...64,647,446
Ensembl chr11:64,646,726...64,647,337 		JBrowse link
G Ubxn2b UBX domain protein 2B involved_in ISO UniProtKB:Q9UNZ2 (PMID:23649807) RGD PMID:23649807 NCBI chr 5:19,303,634...19,333,181
Ensembl chr 5:19,303,682...19,326,849 		JBrowse link
regulation of mitotic centrosome separation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep85 centrosomal protein 85 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr 5:146,356,571...146,404,155
Ensembl chr 5:146,356,576...146,404,060 		JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO
ISS		 (PMID:15311285)
GO_REF:0000024		 RGD
UniProt		 PMID:15311285 GO_REF:0000024 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Kif11 kinesin family member 11 involved_in ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766 		JBrowse link
G Map9 microtubule-associated protein 9 involved_in ISO (PMID:16049101) RGD PMID:16049101 NCBI chr 2:167,708,661...167,743,927
Ensembl chr 2:167,708,765...167,740,736 		JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:26220856) RGD PMID:26220856 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    cellular process 18252
      cell cycle process 1284
        centrosome separation 14
          mitotic centrosome separation + 13
Path 2
Term Annotations click to browse term
  biological_process 19574
    cellular process 18252
      cellular component organization or biogenesis 6851
        cellular component organization 6591
          organelle organization 3657
            cytoskeleton organization 1514
              microtubule cytoskeleton organization 658
                microtubule organizing center organization 159
                  centrosome cycle 144
                    centrosome separation 14
                      mitotic centrosome separation + 13
paths to the root