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ONTOLOGY REPORT - ANNOTATIONS

Term:beta-glucuronidase activity
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Accession:GO:0004566 term browser browse the term
Definition:Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.
Synonyms:related_synonym: beta-D-glucuronoside glucuronosohydrolase activity;   beta-glucuronide glucuronohydrolase activity;   exo-beta-D-glucuronidase activity;   glucuronidase activity;   ketodase activity
 xref: EC:3.2.1.31;   MetaCyc:BETA-GLUCURONID-RXN;   RHEA:17633;   Reactome:R-HSA-2318373 "Defective GUSB does not hydrolyse (HA)2";   Reactome:R-HSA-9036068 "Defective GUSB does not hydrolyse GlcA-1,3-GlcNAc";   Reactome:R-HSA-9036070 "Defective GUSB does not hydrolyse CS/HS precursor";   reactome:R-HSA-1678854 "GUSB tetramer hydrolyses CS/HS precursor";   reactome:R-HSA-2162226 "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc";   reactome:R-HSA-2162227 "GUSB tetramer hydrolyses (HA)2"

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beta-glucuronidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G M Afp alpha fetoprotein enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766 		JBrowse link
G N Gusb glucuronidase beta enables ISO (PMID:20385825)
(PMID:9774663)
(PMID:1914521), (PMID:19751987), (PMID:4777306), (PMID:4841576), (PMID:7203014), (PMID:8200966)
(PMID:11273777)		 RGD
MGI		 PMID:1914521 PMID:3355537 PMID:4777306 PMID:4841576 PMID:7203014 More... RGD:1625498 RGD:1625507 RGD:728562 NCBI chrNW_004624740:8,390,096...8,401,063
Ensembl chrNW_004624740:8,390,197...8,401,387 		JBrowse link
G G GUSB glucuronidase beta enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr28:1,679,682...1,699,238 JBrowse link
G P GUSB glucuronidase beta enables ISO
IBA
IEA		 RGD
GO_Central
UniProt
RHEA		 PMID:3355537 PMID:8702598 PMID:8717430 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 RGD:1625498 RGD:1625507 RGD:728562 NCBI chr 3:16,672,071...16,686,520
Ensembl chr 3:16,671,389...16,689,203 		JBrowse link
G S Gusb glucuronidase beta enables ISO
IEA		 RGD
TreeGrafter
RHEA
UniProt
Ensembl		 PMID:3355537 PMID:8702598 PMID:8717430 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:1625498 RGD:1625507 RGD:728562 NCBI chrNW_004936543:7,721,273...7,732,468
Ensembl chrNW_004936543:7,721,763...7,731,897 		JBrowse link
G D GUSB glucuronidase beta enables ISO
IEA
IBA		 RGD
TreeGrafter
GO_Central
RHEA
UniProt		 PMID:3355537 PMID:8702598 PMID:8717430 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000118 RGD:1625498 RGD:1625507 RGD:728562 NCBI chr 6:730,345...743,916
Ensembl chr 6:730,358...779,424 		JBrowse link
G B GUSB glucuronidase beta enables ISO
IEA		 RGD
TreeGrafter
UniProt
RHEA		 PMID:3355537 PMID:8702598 PMID:8717430 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 RGD:1625498 RGD:1625507 RGD:728562 NCBI chr 7:60,087,130...60,109,289
Ensembl chr 7:64,724,841...64,744,909 		JBrowse link
G C Gusb glucuronidase beta enables ISO (PMID:9774663)
(PMID:20385825)
(PMID:11273777)
(PMID:1914521), (PMID:19751987), (PMID:4777306), (PMID:4841576), (PMID:7203014), (PMID:8200966)		 RGD
MGI		 PMID:1914521 PMID:3355537 PMID:4777306 PMID:4841576 PMID:7203014 More... RGD:1625498 RGD:1625507 RGD:728562 NCBI chrNW_004955456:8,377,161...8,392,298
Ensembl chrNW_004955456:8,378,654...8,392,252 		JBrowse link
G R Gusb glucuronidase, beta enables IDA
ISO
IBA
IEA
IMP		 MGI:1856041|MGI:2152564 (PMID:11273777), (PMID:1914521), (PMID:19751987), (PMID:20385825), (PMID:4777306), (PMID:4841576), (PMID:7203014), (PMID:8200966), (PMID:9774663)
GO_REF:0000033
GO_REF:0000116
GO_REF:0000003		 RGD
GO_Central
RHEA
UniProt		 PMID:1914521 PMID:4777306 PMID:4841576 PMID:7203014 PMID:8200966 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:728562, RGD:1625498, RGD:1625507 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G M Gusb glucuronidase, beta enables ISO
IDA
IMP
IBA		 (PMID:1914521), (PMID:19751987), (PMID:4777306), (PMID:4841576), (PMID:7203014), (PMID:8200966)
(PMID:20385825)
(PMID:9774663)
(PMID:11273777)
(PMID:7354065)
(PMID:6459778)		 MGI
GO_Central
RGD		 PMID:1914521 PMID:3355537 PMID:4777306 PMID:4841576 PMID:6459778 More... GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1625498 RGD:1625507 RGD:728562 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890 		JBrowse link
G H GUSB glucuronidase beta enables ISO
IBA
TAS
IEA		 (PMID:3468507) RGD
GO_Central
Reactome
RHEA
UniProt
Ensembl		 PMID:3355537 PMID:3468507 PMID:8702598 PMID:8717430 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 RGD:1625498 RGD:1625507 RGD:728562 Reactome:R-HSA-2318373 Reactome:R-HSA-9036068 Reactome:R-HSA-9036070 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G H HPSE heparanase enables TAS (PMID:10395325) PINC PMID:10395325 NCBI chr 4:83,292,461...83,335,153
Ensembl chr 4:83,292,461...83,335,153 		JBrowse link
G R Kl Klotho enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G M Kl klotho enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G H KL klotho enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
G G LOC103246571 beta-glucuronidase enables ISO (PMID:1914521), (PMID:19751987), (PMID:4777306), (PMID:4841576), (PMID:7203014), (PMID:8200966)
(PMID:20385825)
(PMID:9774663)
(PMID:11273777)		 RGD
MGI		 PMID:1914521 PMID:3355537 PMID:4777306 PMID:4841576 PMID:7203014 More... RGD:1625498 RGD:1625507 RGD:728562 NCBI chr28:1,621,293...1,646,097
Ensembl chr28:1,620,359...1,646,075 		JBrowse link
G H LOC124905596 putative inactive beta-glucuronidase-like protein SMA3 enables IEA TreeGrafter GO_REF:0000118
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 189906
    catalytic activity 54002
      hydrolase activity 22736
        hydrolase activity, acting on glycosyl bonds 1257
          hydrolase activity, hydrolyzing O-glycosyl compounds 962
            beta-glucuronidase activity 17
paths to the root