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ONTOLOGY REPORT - ANNOTATIONS

Term:exo-alpha-sialidase activity
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Accession:GO:0004308 term browser browse the term
Definition:Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Synonyms:related_synonym: N-acylneuraminate glycohydrolase activity;   acetylneuraminidase activity;   acetylneuraminyl hydrolase activity;   alpha-neuraminidase activity;   neuraminidase activity;   sialidase activity
 xref: EC:3.2.1.18;   MetaCyc:3.2.1.18-RXN;   Reactome:R-HSA-1605723 "NEU2 cleaves GM3 to form LacCer (cytosol)";   Reactome:R-HSA-1605724 "NEU1,4 hydrolyze PSAP(195-273):GM3:PE";   Reactome:R-HSA-1605768 "NEU3 cleaves GM3 to form LacCer (plasma membrane)";   Reactome:R-HSA-4084999 "NEU1 hydrolyses Neu5Ac from glycoconjugates";   Reactome:R-HSA-4341669 "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates";   Reactome:R-HSA-9638120 "NEU4 hydrolyses Neu5Ac from glycoconjugates";   reactome:R-HSA-168870 "Neuraminidase enzymatic release from sialic acid";   reactome:R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates";   reactome:R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates"

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exo-alpha-sialidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B LOC117979510 sialidase-4 enables IEA Ensembl
InterPro
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr2B:129,087,519...129,093,811 JBrowse link
G N Neu1 neuraminidase 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:2393382 GO_REF:0000002 GO_REF:0000117 GO_REF:0000118 RGD:7242745 NCBI chrNW_004624754:24,382,509...24,386,410
Ensembl chrNW_004624754:24,382,467...24,387,874 		JBrowse link
G G NEU1 neuraminidase 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl
InterPro		 PMID:2393382 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:7242745 NCBI chr17:40,158,530...40,162,254
Ensembl chr17:40,158,679...40,161,723 		JBrowse link
G P NEU1 neuraminidase 1 enables ISO
IBA
IEA
ISS		 RGD
GO_Central
UniProt
Ensembl
InterPro		 PMID:2393382 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 RGD:7242745 NCBI chr 7:23,953,721...23,958,659
Ensembl chr 7:23,947,061...23,958,666 		JBrowse link
G S Neu1 neuraminidase 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl
InterPro		 PMID:2393382 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:7242745 NCBI chrNW_004936727:1,683,283...1,687,130
Ensembl chrNW_004936727:1,683,204...1,688,883 		JBrowse link
G D NEU1 neuraminidase 1 enables ISO
IEA		 RGD
Ensembl
UniProt
InterPro		 PMID:2393382 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 RGD:7242745 NCBI chr12:1,323,659...1,327,989
Ensembl chr12:1,323,877...1,328,520 		JBrowse link
G B NEU1 neuraminidase 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro
Ensembl		 PMID:2393382 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:7242745 NCBI chr 6:31,522,392...31,526,097
Ensembl chr 6:32,409,217...32,412,971 		JBrowse link
G C Neu1 neuraminidase 1 enables ISO (PMID:9425240)
(PMID:8985184)		 RGD
MGI
UniProt		 PMID:2393382 PMID:8985184 PMID:9425240 RGD:7242745 NCBI chrNW_004955437:378,708...383,076
Ensembl chrNW_004955437:378,708...383,085 		JBrowse link
G R Neu1 neuraminidase 1 enables IDA
ISO
IBA		 (PMID:9425240)
GO_REF:0000033
(PMID:8985184)		 RGD
GO_Central		 PMID:8985184 PMID:9425240 PMID:2393382 GO_REF:0000033, RGD:7242745 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745 		JBrowse link
G M Neu1 neuraminidase 1 enables ISO
IDA
IBA		 (PMID:9425240) MGI
GO_Central
RGD		 PMID:2393382 PMID:9425240 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:7242745 NCBI chr17:35,150,229...35,156,273
Ensembl chr17:35,150,229...35,154,929 		JBrowse link
G H NEU1 neuraminidase 1 enables ISO
IBA
IEA
IDA
TAS		 (PMID:8985184) RGD
GO_Central
UniProt
Ensembl
Reactome
InterPro		 PMID:2393382 PMID:8985184 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 RGD:7242745 Reactome:R-HSA-4084999 NCBI chr 6:31,857,659...31,862,821
Ensembl chr 6:31,857,659...31,862,905 		JBrowse link
G N Neu2 neuraminidase 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro
UniProt		 PMID:15710387 GO_REF:0000002 GO_REF:0000117 GO_REF:0000118 RGD:2316559 NCBI chrNW_004624843:5,666,959...5,671,833
Ensembl chrNW_004624843:5,665,448...5,670,832 		JBrowse link
G G NEU2 neuraminidase 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro
UniProt
Ensembl		 PMID:15710387 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:2316559 NCBI chr10:119,064,910...119,069,595
Ensembl chr10:119,066,733...119,069,118 		JBrowse link
G P NEU2 neuraminidase 2 enables ISO
IBA
IEA		 RGD
GO_Central
InterPro
UniProt
Ensembl		 PMID:15710387 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 RGD:2316559 NCBI chr15:133,392,559...133,479,406
Ensembl chr15:133,468,293...133,477,110 		JBrowse link
G S Neu2 neuraminidase 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro
UniProt
Ensembl		 PMID:15710387 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:2316559 NCBI chrNW_004936525:4,177,085...4,179,692
Ensembl chrNW_004936525:4,177,085...4,179,692 		JBrowse link
G D NEU2 neuraminidase 2 enables ISO
IEA		 RGD
Ensembl
InterPro
UniProt		 PMID:15710387 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 RGD:2316559 NCBI chr25:44,563,664...44,596,837
Ensembl chr25:44,563,411...44,595,653 		JBrowse link
G B NEU2 neuraminidase 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro
UniProt
Ensembl		 PMID:15710387 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:2316559 NCBI chr2B:120,260,420...120,262,930
Ensembl chr2B:239,174,532...239,176,917 		JBrowse link
G C Neu2 neuraminidase 2 enables ISO (PMID:26193330) RGD
CAFA		 PMID:15710387 PMID:26193330 RGD:2316559 NCBI chrNW_004955453:3,054,626...3,063,070
Ensembl chrNW_004955453:3,052,297...3,061,791 		JBrowse link
G R Neu2 neuraminidase 2 enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000117
(PMID:26193330)		 GO_Central
UniProt
RGD		 PMID:26193330 PMID:15710387 GO_REF:0000033 GO_REF:0000117, RGD:2316559 NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:88,249,135...88,267,355 		JBrowse link
G M Neu2 neuraminidase 2 enables ISO
IBA
IEA		 MGI
GO_Central
UniProt
RGD		 PMID:15710387 GO_REF:0000003 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:2316559 NCBI chr 1:87,501,749...87,525,567
Ensembl chr 1:87,437,611...87,525,567 		JBrowse link
G H NEU2 neuraminidase 2 enables ISO
IBA
IEA
IDA
TAS		 (PMID:26193330) RGD
GO_Central
InterPro
UniProt
CAFA
Reactome		 PMID:15710387 PMID:26193330 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 RGD:2316559 Reactome:R-HSA-1605723 Reactome:R-HSA-4085029 NCBI chr 2:233,032,672...233,035,057
Ensembl chr 2:233,032,672...233,035,057 		JBrowse link
G N Neu3 neuraminidase 3 enables ISO (PMID:10861246) UniProt PMID:10861246 NCBI chrNW_004624817:2,107,893...2,133,626 JBrowse link
G G NEU3 neuraminidase 3 enables ISO (PMID:10861246) UniProt PMID:10861246 NCBI chr 1:66,220,472...66,243,163 JBrowse link
G G NEU3 neuraminidase 3 enables IEA Ensembl
TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 Ensembl chr 1:66,221,012...66,243,919 JBrowse link
G P NEU3 neuraminidase 3 enables IEA
IBA		 Ensembl
GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 9:9,315,263...9,333,878
Ensembl chr 9:9,315,334...9,334,918 		JBrowse link
G S Neu3 neuraminidase 3 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004936498:3,897,511...3,915,013
Ensembl chrNW_004936498:3,897,485...3,910,115 		JBrowse link
G D NEU3 neuraminidase 3 enables IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr21:23,456,424...23,484,872 JBrowse link
G B NEU3 neuraminidase 3 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr11:70,047,878...70,070,303
Ensembl chr11:73,353,332...73,373,270 		JBrowse link
G C Neu3 neuraminidase 3 enables ISO (PMID:10861246) UniProt PMID:10861246 NCBI chrNW_004955414:16,783,996...16,798,368
Ensembl chrNW_004955414:16,788,171...16,798,535 		JBrowse link
G R Neu3 neuraminidase 3 enables ISO
IBA		 (PMID:10861246)
GO_REF:0000033		 RGD
GO_Central		 PMID:10861246 GO_REF:0000033 NCBI chr 1:154,137,732...154,148,879
Ensembl chr 1:154,050,855...154,148,813 		JBrowse link
G M Neu3 neuraminidase 3 enables ISO
IEA
IBA		 MGI
UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:99,460,646...99,477,579
Ensembl chr 7:99,460,646...99,477,624 		JBrowse link
G H NEU3 neuraminidase 3 enables TAS
IBA
IEA
IDA		 (PMID:10861246) Reactome
GO_Central
InterPro
UniProt		 PMID:10861246 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 Reactome:R-HSA-1605768 Reactome:R-HSA-4084994 NCBI chr11:74,980,515...75,020,676
Ensembl chr11:74,988,279...75,018,893 		JBrowse link
G N Neu4 neuraminidase 4 enables IEA UniProt
TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004624847:5,716,165...5,720,542
Ensembl chrNW_004624847:5,716,659...5,720,542 		JBrowse link
G G NEU4 neuraminidase 4 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr10:127,845,536...127,852,873
Ensembl chr10:127,847,391...127,852,519 		JBrowse link
G P NEU4 neuraminidase 4 enables IEA Ensembl
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr15:140,324,087...140,332,226
Ensembl chr15:140,325,135...140,328,276 		JBrowse link
G S Neu4 neuraminidase 4 enables ISO (PMID:14962670), (PMID:15213228)
(PMID:14637003)		 UniProt
MGI		 PMID:14637003 PMID:14962670 PMID:15213228 NCBI chrNW_004936745:172,983...175,470 JBrowse link
G D NEU4 neuraminidase 4 enables IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr25:51,594,865...51,602,500 JBrowse link
G B NEU4 neuraminidase 4 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr12:130,824,179...130,833,287 JBrowse link
G C Neu4 neuraminidase 4 enables ISO (PMID:14962670), (PMID:15213228)
(PMID:14637003)		 UniProt
MGI		 PMID:14637003 PMID:14962670 PMID:15213228 NCBI chrNW_004955542:66,214...70,456
Ensembl chrNW_004955542:66,174...71,058 		JBrowse link
G R Neu4 neuraminidase 4 enables ISO
IBA		 (PMID:14962670), (PMID:15213228)
(PMID:14637003)
GO_REF:0000033		 RGD
GO_Central		 PMID:14637003 PMID:14962670 PMID:15213228 GO_REF:0000033 NCBI chr 9:94,396,920...94,402,576
Ensembl chr 9:94,396,920...94,402,576 		JBrowse link
G M Neu4 sialidase 4 enables ISO
IBA
IDA		 (PMID:14637003) MGI
GO_Central		 PMID:14637003 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:93,948,215...93,956,056
Ensembl chr 1:93,948,173...93,956,056 		JBrowse link
G H NEU4 neuraminidase 4 enables IEA
IBA
TAS
IDA		 (PMID:14962670), (PMID:15213228) Ensembl
GO_Central
InterPro
UniProt
Reactome		 PMID:14962670 PMID:15213228 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 Reactome:R-HSA-9638120 NCBI chr 2:241,809,193...241,817,413
Ensembl chr 2:241,809,065...241,817,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 189980
    catalytic activity 54016
      hydrolase activity 22775
        hydrolase activity, acting on glycosyl bonds 1221
          hydrolase activity, hydrolyzing O-glycosyl compounds 922
            alpha-sialidase activity 42
              exo-alpha-sialidase activity 42
paths to the root