NEU4 (neuraminidase 4) - Rat Genome Database

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Gene: NEU4 (neuraminidase 4) Sus scrofa
Analyze
Symbol: NEU4
Name: neuraminidase 4
RGD ID: 14048904
Description: ENCODES a protein that exhibits exo-alpha-sialidase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN ganglioside catabolic process (inferred); glycoprotein catabolic process (inferred); lipid catabolic process (inferred); ASSOCIATED WITH Bethlem Myopathy 1A (ortholog); chromosome 2q37 deletion syndrome (ortholog); D-2-hydroxyglutaric aciduria 1 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); lysosome (ortholog); mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sialidase-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,325,852 - 140,331,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,324,087 - 140,332,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NEU4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,325,852 - 140,331,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,324,087 - 140,332,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NEU4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,809,193 - 241,817,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,809,065 - 241,817,413 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,750,288 - 242,758,739 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,400,746 - 242,407,407 (+)NCBINCBI36Build 36hg18NCBI36
Build 342242,472,062 - 242,478,724NCBI
Celera2236,415,462 - 236,423,972 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,501,226 - 234,509,785 (+)NCBIHuRef
CHM1_12242,756,215 - 242,764,748 (+)NCBICHM1_1
T2T-CHM13v2.02242,310,986 - 242,319,206 (+)NCBIT2T-CHM13v2.0
Neu4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,948,215 - 93,956,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,948,173 - 93,956,056 (+)EnsemblGRCm39 Ensembl
GRCm38194,020,493 - 94,028,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,020,451 - 94,028,334 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,917,070 - 95,924,911 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,850,899 - 95,858,740 (+)NCBIMGSCv36mm8
Celera196,885,435 - 96,893,274 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.46NCBI
Neu4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,844,261 - 101,849,917 (+)NCBIGRCr8
mRatBN7.2994,396,920 - 94,402,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,396,920 - 94,402,576 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,832,389 - 102,838,045 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,967,672 - 107,973,326 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,323,784 - 106,329,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09101,284,902 - 101,290,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,284,902 - 101,290,558 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,005,082 - 101,008,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,655,816 - 100,661,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,150,680 - 93,156,336 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,343,347 - 93,360,169 (+)NCBI
Celera991,931,048 - 91,936,704 (+)NCBICelera
Cytogenetic Map9q36NCBI
Neu4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554266,174 - 71,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495554266,214 - 70,456 (-)NCBIChiLan1.0ChiLan1.0
NEU4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,517,325 - 144,526,774 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,532,652 - 144,541,671 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012130,824,179 - 130,833,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NEU4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,594,865 - 51,602,500 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,815,995 - 51,824,531 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,795,643 - 51,804,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,782,762 - 51,803,768 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,645,546 - 51,654,141 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,384,795 - 51,393,349 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,661,976 - 51,670,484 (+)NCBIUU_Cfam_GSD_1.0
Neu4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303193,042,611 - 193,054,249 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936745172,983 - 175,470 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEU4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,845,536 - 127,852,873 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,847,391 - 127,852,519 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604071,467,646 - 71,474,913 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Neu4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,716,659 - 5,720,542 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,716,165 - 5,720,542 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NEU4
109 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 2 21 1 4 5 5 21 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021074822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000038228   ⟹   ENSSSCP00000045378
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15140,325,621 - 140,328,148 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000044214   ⟹   ENSSSCP00000058321
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15140,325,852 - 140,331,529 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000072528   ⟹   ENSSSCP00000065445
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15140,325,852 - 140,328,640 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000079408   ⟹   ENSSSCP00000066735
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15140,325,212 - 140,328,276 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000079970   ⟹   ENSSSCP00000059805
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15140,325,135 - 140,328,148 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000085116   ⟹   ENSSSCP00000066177
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15140,325,375 - 140,328,276 (+)Ensembl
RefSeq Acc Id: XM_021074822   ⟹   XP_020930481
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115140,324,087 - 140,332,226 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020930481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000058321
  ENSSSCP00000058321.2
  ENSSSCP00000059805.2
  ENSSSCP00000066177.1
  ENSSSCP00000066735.1
  ENSSSCP00030015435.1
  ENSSSCP00040044130.1
  ENSSSCP00050015215.1
RefSeq Acc Id: XP_020930481   ⟸   XM_021074822
- UniProtKB: A0A8D1FWM2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000058321   ⟸   ENSSSCT00000044214
Ensembl Acc Id: ENSSSCP00000059805   ⟸   ENSSSCT00000079970
Ensembl Acc Id: ENSSSCP00000066177   ⟸   ENSSSCT00000085116
Ensembl Acc Id: ENSSSCP00000066735   ⟸   ENSSSCT00000079408
Ensembl Acc Id: ENSSSCP00000045378   ⟸   ENSSSCT00000038228
Ensembl Acc Id: ENSSSCP00000065445   ⟸   ENSSSCT00000072528
Protein Domains
Sialidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030024433 UniProtKB/TrEMBL
  ENSSSCG00040071802 UniProtKB/TrEMBL
  ENSSSCG00050027212 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000044214 ENTREZGENE
  ENSSSCT00000044214.3 UniProtKB/TrEMBL
  ENSSSCT00000079408.1 UniProtKB/TrEMBL
  ENSSSCT00000079970.2 UniProtKB/TrEMBL
  ENSSSCT00000085116.1 UniProtKB/TrEMBL
  ENSSSCT00030034039.1 UniProtKB/TrEMBL
  ENSSSCT00040098709.1 UniProtKB/TrEMBL
  ENSSSCT00050036600.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.10 UniProtKB/TrEMBL
InterPro Sialidase UniProtKB/TrEMBL
  Sialidase_fam UniProtKB/TrEMBL
  Sialidase_sf UniProtKB/TrEMBL
NCBI Gene NEU4 ENTREZGENE
PANTHER PTHR10628 UniProtKB/TrEMBL
  PTHR10628:SF22 UniProtKB/TrEMBL
Pfam BNR_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF50939 UniProtKB/TrEMBL
UniProt A0A287BP79_PIG UniProtKB/TrEMBL
  A0A5G2Q7K9_PIG UniProtKB/TrEMBL
  A0A5G2QMS1_PIG UniProtKB/TrEMBL
  A0A5G2QPU2_PIG UniProtKB/TrEMBL
  A0A8D1FWM2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:95964 ENTREZGENE