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Gene: NEU2 (neuraminidase 2) Pan paniscus

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Symbol:

NEU2

Name:

neuraminidase 2

RGD ID:

11812950

Description:

ENCODES a protein that exhibits exo-alpha-sialidase activity (ortholog); INVOLVED IN positive regulation of myoblast differentiation (ortholog); positive regulation of myotube differentiation (ortholog); response to ethanol (ortholog); ASSOCIATED WITH Joubert syndrome 22 (ortholog); Perlman syndrome (ortholog); FOUND IN catalytic complex (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sialidase-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NEU2 (neuraminidase 2)	NCBI	Ortholog
Mus musculus (house mouse):	Neu2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Neu2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Neu2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NEU2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Neu2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NEU2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NEU2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Neu2 (neuraminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	135,634,219 - 135,636,729 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	135,649,184 - 135,651,694 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	120,260,420 - 120,262,930 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	239,174,532 - 239,176,917 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	239,174,532 - 239,176,917 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Joubert syndrome 22 (ISO)

Perlman syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ganglioside catabolic process (IEA)

glycoprotein catabolic process (IEA)

lipid catabolic process (IEA)

oligosaccharide catabolic process (IEA)

positive regulation of myoblast differentiation (ISO)

positive regulation of myotube differentiation (ISO)

response to ethanol (ISO)

Cellular Component

catalytic complex (IEA)

cytoplasm (IEA)

cytosol (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

Molecular Function

exo-alpha-sialidase activity (IEA,ISO)

hydrolase activity, acting on glycosyl bonds (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

NEU2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	135,634,219 - 135,636,729 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	135,649,184 - 135,651,694 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	120,260,420 - 120,262,930 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	239,174,532 - 239,176,917 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	239,174,532 - 239,176,917 (+)	Ensembl	panpan1.1		panPan2

NEU2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	233,032,672 - 233,035,057 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	233,032,672 - 233,035,057 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	233,897,382 - 233,899,767 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	233,605,626 - 233,608,011 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	233,722,886 - 233,725,272	NCBI
Celera	2	227,661,195 - 227,663,580 (+)	NCBI		Celera
Cytogenetic Map	2	q37.1	NCBI
HuRef	2	225,744,667 - 225,747,052 (+)	NCBI		HuRef
CHM1_1	2	233,903,172 - 233,905,557 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	233,520,063 - 233,522,448 (+)	NCBI		T2T-CHM13v2.0

Neu2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	87,501,749 - 87,525,567 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	87,437,611 - 87,525,567 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	87,574,027 - 87,597,845 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	87,509,889 - 87,597,845 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	89,470,602 - 89,494,420 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	89,425,721 - 89,428,998 (+)	NCBI		MGSCv36	mm8
Celera	1	90,540,068 - 90,564,044 (+)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	44.44	NCBI

Neu2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	95,666,338 - 95,715,209 (+)	NCBI		GRCr8
mRatBN7.2	9	88,218,494 - 88,267,356 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	88,249,135 - 88,267,355 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	96,688,673 - 96,691,886 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	101,824,744 - 101,827,957 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	100,192,362 - 100,195,578 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	94,702,095 - 94,724,903 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	94,702,129 - 94,724,902 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	94,396,233 - 94,444,063 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	86,553,196 - 86,556,412 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	86,736,614 - 86,739,826 (+)	NCBI
Celera	9	85,673,821 - 85,677,037 (+)	NCBI		Celera
Cytogenetic Map	9	q35	NCBI

Neu2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	3,052,297 - 3,061,791 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	3,054,626 - 3,063,070 (-)	NCBI	ChiLan1.0	ChiLan1.0

NEU2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	44,563,664 - 44,596,837 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	44,563,411 - 44,595,653 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	45,058,963 - 45,092,889 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	44,823,144 - 44,857,117 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	44,847,543 - 44,855,198 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	44,747,576 - 44,780,743 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	44,623,544 - 44,627,737 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	44,748,930 - 44,782,126 (+)	NCBI		UU_Cfam_GSD_1.0

Neu2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	186,759,883 - 186,764,743 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	4,177,085 - 4,179,692 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	4,177,085 - 4,179,692 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEU2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	133,468,293 - 133,477,110 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	133,392,559 - 133,479,406 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	147,509,793 - 147,545,593 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEU2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	119,064,910 - 119,069,595 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	119,066,733 - 119,069,118 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	80,438,488 - 80,441,155 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Neu2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624843	5,665,448 - 5,670,832 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624843	5,666,959 - 5,671,833 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003813133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000052606 ⟹ ENSPPAP00000029755

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2B	239,174,532 - 239,176,917 (+)	Ensembl

RefSeq Acc Id:

XM_003813133 ⟹ XP_003813181

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	13	135,634,219 - 135,636,729 (+)	NCBI
NHGRI_mPanPan1	2B	135,649,184 - 135,651,694 (+)	NCBI
Mhudiblu_PPA_v0	2B	120,260,420 - 120,262,930 (+)	NCBI
PanPan1.1	2B	239,174,532 - 239,176,917 (+)	NCBI

Sequence:

show sequence

ATGGCGTCCCTCCCTGTCCTGCAGAAGGAGAGCGTGTTCCAGTCGGGAGCCCATGCCTACAGAA
TCCCTGCCCTGCTCTACCTGCCTGGGCAGCAGACCCTGCTGGCCTTCGCGGAACAGCGGGCAAG
CAAGAAGGATGAGCACGCGGAGCTGATTGTCCTGCGCAGAGGAGACTACGATGCACCCACCCAC
CAGGTTCAGTGGCAAGCTCAGGAGGTGGTGGCCCAGGCCCGGCTGGATGGCCACCGGTCCATGA
ACCCATGCCCCTTGTATGACGCGCAGACGGAGACCCTCTTCCTCTTCTTCATTGCCATCCCTGG
GCAAGTCACGGAGCAACAGCAGCTGCAGACCAGGGCCAATGTGACGCGGCTGTGCCAAGTCACC
AGCACTGACCACGGGAGGACCTGGAGCTCCCCCAGAGACCTCACTGATGCGGCCATCGGCCCAG
CCTACCGGGAGTGGTCCACCTTTGCAGTGGGCCCGGGGCATTGTTTGCAGCTTCATGACAGGGC
CCGGAGCCTGGTGGTGCCCGCCTACGCCTACCGGAAACTTCACCCCATCCAAAGGCCAAGCCCC
TCTGCCTTCTGCTTCCTCAGCCATGACCATGGGCACACGTGGGTGCGAGGGCATTTTGTGGCCC
AGGACACCCTGGAGTGCCAGGTGGCCGAAGTCGAGACTGGGGAGCAGAGGGTGGTGACCCTCAA
TGCGAGAAGCCACCTCCAAGCCAGGGTCCAGGCCCAGAGCACCAATGACGGGTTTGATTTCCAG
GAGTCTCAGCTGGTGAAGAAGCTGGTGGAGCCGCCGCCCCAGGGCTGCCAGGGGAGCGTCATCA
GCTTCCCCAGCCCCCGCTCGGGGCCTGGCTCCCCAGCCCAGTGGCTGCTCTACACTCACCCCAC
ACACTCCTGGCAGAGGGCCGACCTGGGTGCCTACCTCAACCCGCGACCTCCAGCCCCTGAGGCC
TGGTCAGAGCCGGTACTGCTGGCTAAGGGCAGCTGTGCCTACTCAGACCTCCAGAGCATGGGCA
CCGGCCCTGATGGGTCCCCCTTGTTTGGGTGTCTGTATGAAGCCAATGATTACGAGGAGATTGT
CTTTCTCATGTTCACCCTGAAGCAGGCCTTCCCAGCTGAGTACCTGCCTCAGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003813181	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000029755.1

RefSeq Acc Id:

XP_003813181 ⟸ XM_003813133

- Sequence:

show sequence

MASLPVLQKESVFQSGAHAYRIPALLYLPGQQTLLAFAEQRASKKDEHAELIVLRRGDYDAPTH
QVQWQAQEVVAQARLDGHRSMNPCPLYDAQTETLFLFFIAIPGQVTEQQQLQTRANVTRLCQVT
STDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPSP
SAFCFLSHDHGHTWVRGHFVAQDTLECQVAEVETGEQRVVTLNARSHLQARVQAQSTNDGFDFQ
ESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEA
WSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ

hide sequence

Ensembl Acc Id:

ENSPPAP00000029755 ⟸ ENSPPAT00000052606

Protein Domains

Sialidase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037902	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000052606.1	UniProtKB/TrEMBL
Gene3D-CATH	2.120.10.10	UniProtKB/TrEMBL
InterPro	Sialidase	UniProtKB/TrEMBL
	Sialidase_fam	UniProtKB/TrEMBL
	Sialidase_sf	UniProtKB/TrEMBL
KEGG Report	pps:100988881	UniProtKB/TrEMBL
NCBI Gene	NEU2	ENTREZGENE
PANTHER	PTHR10628	UniProtKB/TrEMBL
	PTHR10628:SF6	UniProtKB/TrEMBL
Pfam	BNR_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50939	UniProtKB/TrEMBL
UniProt	A0A2R9BJ98_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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