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ONTOLOGY REPORT - ANNOTATIONS

Term:NAD+ ADP-ribosyltransferase activity
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Accession:GO:0003950 term browser browse the term
Definition:Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Synonyms:related_synonym: ADP-ribosyltransferase (polymerizing) activity;   NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity;   poly(ADP-ribose) synthase activity;   poly(ADP-ribose) synthetase activity;   poly(ADP-ribose)polymerase activity;   poly(adenosine diphosphate ribose) polymerase activity
 xref: EC:2.4.2.30;   MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN;   Reactome:R-HSA-9686061 "Nucleoprotein is ADP-ribosylated";   Reactome:R-HSA-9729279 "Nucleoprotein is ADP-ribosylated";   reactome:R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4";   reactome:R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN";   reactome:R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate";   reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate";   reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD";   reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)";   reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN"


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NAD+ ADP-ribosyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ART1 ADP-ribosyltransferase 1 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr11:3,645,128...3,664,416
Ensembl chr11:3,645,128...3,664,416 		JBrowse link
G ART3 ADP-ribosyltransferase 3 (inactive) enables IBA GO_Central GO_REF:0000033 NCBI chr 4:76,011,190...76,112,786
Ensembl chr 4:76,011,184...76,114,048 		JBrowse link
G ART4 ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr12:14,825,569...14,843,526
Ensembl chr12:14,825,569...14,843,526 		JBrowse link
G ART5 ADP-ribosyltransferase 5 enables IBA GO_Central GO_REF:0000033 NCBI chr11:3,638,512...3,642,379
Ensembl chr11:3,638,512...3,642,316 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 enables ISO
IBA
IEA
IDA
IMP
TAS		 (PMID:16107709), (PMID:17396150), (PMID:18055453), (PMID:19470756), (PMID:19764761), (PMID:20388712), (PMID:23275542), (PMID:26626479), (PMID:26626480), (PMID:28190768), (PMID:30104678), (PMID:32028527), (PMID:32241924), (PMID:32358582), (PMID:33186521), (PMID:33683197), (PMID:34732825), (PMID:34795260), (PMID:35219381), (PMID:7852410)
(PMID:22504299)
(PMID:2513174)		 RGD
GO_Central
TreeGrafter
UniProt
InterPro
CAFA
Ensembl
PINC		 PMID:2513174 PMID:7852410 PMID:15857403 PMID:16107709 PMID:16302026 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1601079 RGD:1601082 Reactome:R-HSA-2187325 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PARP10 poly(ADP-ribose) polymerase family member 10 enables TAS
IEA
IBA
IMP		 (PMID:23473667), (PMID:23575687) Reactome
TreeGrafter
GO_Central
InterPro
UniProt		 PMID:23473667 PMID:23575687 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 Reactome:R-HSA-8938073 Reactome:R-HSA-9686061 NCBI chr 8:143,977,158...144,012,764
Ensembl chr 8:143,977,153...144,012,772 		JBrowse link
G PARP11 poly(ADP-ribose) polymerase family member 11 enables IEA
IBA
IDA		 (PMID:25673562) InterPro
GO_Central
MGI		 PMID:25673562 GO_REF:0000002 GO_REF:0000033 NCBI chr12:3,808,861...3,873,399
Ensembl chr12:3,791,047...3,873,448 		JBrowse link
G PARP12 poly(ADP-ribose) polymerase family member 12 enables IEA
IBA		 InterPro
TreeGrafter
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr 7:140,023,749...140,062,951
Ensembl chr 7:140,023,749...140,062,951 		JBrowse link
G PARP14 poly(ADP-ribose) polymerase family member 14 enables IDA
IEA
IBA
IMP		 (PMID:27796300)
(PMID:16061477)		 UniProt
TreeGrafter
GO_Central
InterPro		 PMID:16061477 PMID:27796300 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:122,680,839...122,730,840
Ensembl chr 3:122,680,839...122,730,840 		JBrowse link
G PARP15 poly(ADP-ribose) polymerase family member 15 enables IMP
IEA
IBA		 (PMID:16061477), (PMID:25635049) UniProt
TreeGrafter
GO_Central
InterPro		 PMID:16061477 PMID:25635049 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr 3:122,577,650...122,639,047
Ensembl chr 3:122,577,628...122,639,047 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 enables TAS
IBA
IEA
IMP		 (PMID:22701565), (PMID:23103912) Reactome
GO_Central
InterPro
UniProt		 PMID:22701565 PMID:23103912 GO_REF:0000002 GO_REF:0000033 Reactome:R-HSA-8938073 Reactome:R-HSA-9686061 NCBI chr15:65,230,917...65,286,883
Ensembl chr15:65,234,460...65,300,618 		JBrowse link
G PARP2 poly(ADP-ribose) polymerase 2 enables IEA
IBA
IDA		 (PMID:30104678), (PMID:32028527), (PMID:32939087), (PMID:34732825), (PMID:34795260) UniProt
GO_Central
TreeGrafter
Ensembl
InterPro		 PMID:30104678 PMID:32028527 PMID:32939087 PMID:34732825 PMID:34795260 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr14:20,343,635...20,357,904
Ensembl chr14:20,343,615...20,357,904 		JBrowse link
G PARP3 poly(ADP-ribose) polymerase family member 3 enables IDA
IEA
IBA		 (PMID:21211721), (PMID:21270334) MGI
TreeGrafter
GO_Central
InterPro
UniProt		 PMID:21211721 PMID:21270334 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr 3:51,942,363...51,948,867
Ensembl chr 3:51,942,345...51,948,867 		JBrowse link
G PARP4 poly(ADP-ribose) polymerase family member 4 enables NAS
IEA
IDA
TAS
IBA		 (PMID:10644454)
(PMID:10477748)
(PMID:10100603)		 UniProt
InterPro
PINC
GO_Central
TreeGrafter		 PMID:10100603 PMID:10477748 PMID:10644454 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr13:24,420,931...24,512,778
Ensembl chr13:24,420,931...24,512,778 		JBrowse link
G PARP6 poly(ADP-ribose) polymerase family member 6 enables IEA
IBA		 UniProt
GO_Central
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr15:72,241,181...72,272,554
Ensembl chr15:72,241,181...72,272,999 		JBrowse link
G PARP8 poly(ADP-ribose) polymerase family member 8 enables IEA
IBA		 InterPro
GO_Central
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr 5:50,665,931...50,846,519
Ensembl chr 5:50,665,899...50,846,519 		JBrowse link
G PARP9 poly(ADP-ribose) polymerase family member 9 enables
NOT|enables		 TAS
IEA
IBA
IDA
IMP		 (PMID:23230272)
(PMID:16061477)		 Reactome
TreeGrafter
GO_Central
UniProt
InterPro		 PMID:16061477 PMID:23230272 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 Reactome:R-HSA-8938073 Reactome:R-HSA-9686061 NCBI chr 3:122,527,924...122,564,784
Ensembl chr 3:122,527,924...122,564,577 		JBrowse link
G SIRT1 sirtuin 1 NOT|enables TAS (PMID:17456799) BHF-UCL PMID:17456799 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables
NOT|enables		 IDA
TAS		 (PMID:10381378)
(PMID:17456799)		 GO_Central
BHF-UCL		 PMID:10381378 PMID:17456799 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 NOT|enables TAS (PMID:17456799) BHF-UCL PMID:17456799 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT4 sirtuin 4 enables IDA
TAS
IEA		 (PMID:16959573), (PMID:17715127)
(PMID:17456799)		 UniProt
Reactome
Ensembl		 PMID:16959573 PMID:17456799 PMID:17715127 GO_REF:0000104 GO_REF:0000107 Reactome:R-HSA-5688276 NCBI chr12:120,291,780...120,313,249
Ensembl chr12:120,302,316...120,313,249 		JBrowse link
G SIRT5 sirtuin 5 NOT|enables TAS (PMID:17456799) BHF-UCL PMID:17456799 NCBI chr 6:13,574,274...13,615,158
Ensembl chr 6:13,574,227...13,615,158 		JBrowse link
G SIRT6 sirtuin 6 enables TAS (PMID:17456799) BHF-UCL PMID:17456799 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G TIPARP TCDD inducible poly(ADP-ribose) polymerase enables IEA
IBA
IDA		 (PMID:23275542) InterPro
GO_Central
TreeGrafter
Ensembl
UniProt
MGI		 PMID:23275542 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:156,674,590...156,706,770
Ensembl chr 3:156,673,235...156,706,770 		JBrowse link
G TNKS tankyrase enables TAS
IBA
IEA
IDA		 (PMID:11854288), (PMID:16076287), (PMID:19759537), (PMID:21270334), (PMID:21478859), (PMID:22864114), (PMID:9822378) Reactome
GO_Central
InterPro
UniProt		 PMID:9822378 PMID:11854288 PMID:16076287 PMID:19759537 PMID:21270334 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 Reactome:R-HSA-3640858 Reactome:R-HSA-8948800 NCBI chr 8:9,555,912...9,782,346
Ensembl chr 8:9,555,912...9,782,346 		JBrowse link
G TNKS2 tankyrase 2 enables TAS
IEA
IBA
IDA		 (PMID:19759537), (PMID:21478859) Reactome
UniProt
GO_Central
InterPro		 PMID:19759537 PMID:21478859 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 Reactome:R-HSA-3640858 Reactome:R-HSA-8948800 NCBI chr10:91,798,426...91,865,475
Ensembl chr10:91,798,426...91,865,475 		JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 enables
NOT|enables		 IEA
IMP		 (PMID:25635049) InterPro
TreeGrafter
UniProt		 PMID:25635049 GO_REF:0000002 GO_REF:0000118 NCBI chr 7:139,043,515...139,109,720
Ensembl chr 7:139,043,515...139,132,122 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19487
    catalytic activity 5987
      transferase activity 2464
        glycosyltransferase activity 290
          pentosyltransferase activity 57
            NAD+ ADP-ribosyltransferase activity 27
paths to the root