Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
Synonyms:
narrow_synonym:
DNA polymerase I; DNA polymerase II; DNA polymerase III; DNA polymerase V activity; DNA polymerase alpha; DNA polymerase beta; DNA polymerase gamma; Klenow fragment; Taq DNA polymerase; Taq Pol I; Tca DNA polymerase; alpha DNA polymerase activity; beta DNA polymerase activity; delta DNA polymerase activity; deoxyribonucleic polymerase I; epsilon DNA polymerase activity; eta DNA polymerase activity; gamma DNA-directed DNA polymerase activity; iota DNA polymerase activity; kappa DNA polymerase activity; lambda DNA polymerase activity; mu DNA polymerase activity; nu DNA polymerase activity; sigma DNA polymerase activity; theta DNA polymerase activity; zeta DNA polymerase activity
broad_synonym:
duplicase
related_synonym:
DNA duplicase activity; DNA nucleotidyltransferase (DNA-directed) activity; DNA replicase activity; DNA-dependent DNA polymerase activity; deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity; deoxyribonucleic acid duplicase activity; deoxyribonucleic duplicase activity; sequenase
EC:2.7.7.7; MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN; Reactome:R-HSA-9710480 "Decitabine triphosphate incorporates into DNA"; reactome:R-HSA-110311 "POLZ extends translesion synthesis"; reactome:R-HSA-110317 "Insertion of correct bases opposite the lesion by POLH"; reactome:R-HSA-110319 "Elongation by POLH"; reactome:R-HSA-110368 "POLD,POLE-mediated DNA strand displacement synthesis"; reactome:R-HSA-111253 "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site"; reactome:R-HSA-164505 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand"; reactome:R-HSA-164513 "3' PPT-primed initiation of plus-strand DNA synthesis"; reactome:R-HSA-174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"; reactome:R-HSA-174444 "Formation of C-strand Okazaki fragments"; reactome:R-HSA-5358579 "DNA polymerase delta polymerizes DNA across single stranded gap"; reactome:R-HSA-5649723 "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution"; reactome:R-HSA-5649883 "POLB-mediated DNA strand displacement synthesis"; reactome:R-HSA-5653840 "POLD,POLE complete replication of damaged DNA after TLS"; reactome:R-HSA-5655892 "POLK incorporates dNMP opposite to damaged DNA base"; reactome:R-HSA-5655965 "POLK and POLZ cooperate in elongation of mispaired primer termini"; reactome:R-HSA-5656148 "POLI incorporates dNMP opposite to damaged DNA base"; reactome:R-HSA-5656158 "POLZ elongates POLI-incorporated dNMP"; reactome:R-HSA-5687360 "POLL or POLM extends aligned DNA DSB ends to fill gaps"; reactome:R-HSA-5687640 "POLQ extends annealed 3'-ssDNA overhangs in MMEJ"; reactome:R-HSA-5691001 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER"; reactome:R-HSA-5693593 "D-loop extension by DNA polymerases"; reactome:R-HSA-6782208 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER"; reactome:R-HSA-6786166 "Translesion synthesis across unhooked ICL by POLN"; reactome:R-HSA-68950 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin"; reactome:R-HSA-69116 "Formation of Okazaki fragments"; reactome:R-HSA-73932 "Resynthesis of excised residue by POLB"
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