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ONTOLOGY REPORT - ANNOTATIONS

Term:heart valve development
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Accession:GO:0003170 term browser browse the term
Definition:The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.
Synonyms:exact_synonym: cardiac valve development

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heart valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:25807483) MGI PMID:25807483 NCBI chrNW_004624820:1,097,323...1,196,556
Ensembl chrNW_004624820:1,097,463...1,196,499 		JBrowse link
G Matr3 matrin 3 acts_upstream_of_or_within ISO (PMID:25574029) MGI PMID:25574029 NCBI chrNW_004624743:32,086,821...32,147,079
Ensembl chrNW_004624743:32,115,544...32,146,921 		JBrowse link
G Mdm4 MDM4 regulator of p53 acts_upstream_of_or_within ISO (PMID:22821713) MGI PMID:22821713 NCBI chrNW_004624807:6,480,785...6,522,149
Ensembl chrNW_004624807:6,486,333...6,522,801 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO (PMID:26147524) MGI PMID:26147524 NCBI chrNW_004624795:1,553,582...1,558,110
Ensembl chrNW_004624795:1,553,037...1,558,197 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 involved_in ISO (PMID:22300732) BHF-UCL PMID:22300732 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
G Pde2a phosphodiesterase 2A acts_upstream_of_or_within ISO (PMID:25807483) MGI PMID:25807483 NCBI chrNW_004624817:4,269,422...4,367,576
Ensembl chrNW_004624817:4,269,347...4,369,486 		JBrowse link
G Prdm1 PR/SET domain 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25807483) Ensembl
MGI		 PMID:25807483 GO_REF:0000107 NCBI chrNW_004624780:16,205,056...16,227,382
Ensembl chrNW_004624780:16,204,838...16,227,390 		JBrowse link
G Shox2 SHOX homeobox 2 acts_upstream_of_or_within ISO (PMID:17372176) MGI PMID:17372176 NCBI chrNW_004624730:35,826,631...35,836,141
Ensembl chrNW_004624730:35,825,922...35,835,756 		JBrowse link
G Smad6 SMAD family member 6 acts_upstream_of_or_within ISO (PMID:25807483) MGI PMID:25807483 NCBI chrNW_004624781:6,043,183...6,108,959
Ensembl chrNW_004624781:6,042,904...6,107,860 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISO (PMID:20056916) UniProt PMID:20056916 NCBI chrNW_004624801:2,296,353...2,300,853
Ensembl chrNW_004624801:2,296,168...2,301,596 		JBrowse link
G Zbtb14 zinc finger and BTB domain containing 14 acts_upstream_of_or_within ISO (PMID:25807483) MGI PMID:25807483 NCBI chrNW_004624770:15,016,689...15,021,000
Ensembl chrNW_004624770:15,012,887...15,019,805 		JBrowse link
aortic valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within ISO (PMID:16730346) BHF-UCL PMID:16730346 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:12441304) BHF-UCL PMID:12441304 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 involved_in ISO (PMID:22300732) BHF-UCL PMID:22300732 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624755:6,176,497...6,298,034
Ensembl chrNW_004624755:6,176,497...6,298,225 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in ISO (PMID:15843409) BHF-UCL PMID:15843409 NCBI chrNW_004624740:25,645,526...25,698,235
Ensembl chrNW_004624740:25,645,895...25,697,132 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624860:3,111,244...3,123,041
Ensembl chrNW_004624860:3,111,630...3,122,711 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624818:894,470...922,806
Ensembl chrNW_004624818:896,150...922,710 		JBrowse link
aortic valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh11 cadherin 11 involved_in ISO (PMID:26188246) BHF-UCL PMID:26188246 NCBI chrNW_004624746:21,345,304...21,501,542
Ensembl chrNW_004624746:21,345,310...21,503,822 		JBrowse link
G Rhoa ras homolog family member A involved_in ISO (PMID:26188246) BHF-UCL PMID:26188246 NCBI chrNW_004624730:3,316,122...3,361,820 JBrowse link
aortic valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif 19 involved_in ISO (PMID:31844321), (PMID:32323311) BHF-UCL PMID:31844321 PMID:32323311 NCBI chrNW_004624774:11,631,446...11,900,692
Ensembl chrNW_004624774:11,631,376...11,900,121 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 involved_in ISO (PMID:23531444) BHF-UCL PMID:23531444 NCBI chrNW_004624745:14,890,111...14,934,972
Ensembl chrNW_004624745:14,896,340...14,935,016 		JBrowse link
G Axin2 axin 2 involved_in ISO (PMID:28069701), (PMID:31844321) BHF-UCL PMID:28069701 PMID:31844321 NCBI chrNW_004624870:2,803,743...2,832,489
Ensembl chrNW_004624870:2,800,873...2,832,626 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:15070745), (PMID:18924235) BHF-UCL PMID:15070745 PMID:18924235 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624804:8,179,729...8,189,001
Ensembl chrNW_004624804:8,179,731...8,191,284 		JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:20960543) BHF-UCL PMID:20960543 NCBI chrNW_004624885:2,382,712...2,388,805
Ensembl chrNW_004624885:2,383,045...2,389,107 		JBrowse link
G Eln elastin involved_in ISO (PMID:20576933) BHF-UCL PMID:20576933 NCBI chrNW_004624740:13,856,932...13,886,266 JBrowse link
G Emilin1 elastin microfibril interfacer 1 involved_in ISO (PMID:25056700) BHF-UCL PMID:25056700 NCBI chrNW_004624738:9,180,944...9,189,025
Ensembl chrNW_004624738:9,180,877...9,189,025 		JBrowse link
G Gata3 GATA binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392 		JBrowse link
G Gata4 GATA binding protein 4 involved_in ISO (PMID:29325903) BHF-UCL PMID:29325903 NCBI chrNW_004624758:25,278,878...25,319,317
Ensembl chrNW_004624758:25,278,874...25,319,318 		JBrowse link
G Gata5 GATA binding protein 5 involved_in ISO (PMID:22641149), (PMID:24638895)
(PMID:21633169)		 BHF-UCL PMID:21633169 PMID:22641149 PMID:24638895 NCBI chrNW_004624741:28,310,679...28,322,209
Ensembl chrNW_004624741:28,310,201...28,321,095 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (PMID:22110751) BHF-UCL PMID:22110751 NCBI chrNW_004624744:11,462,865...11,466,559
Ensembl chrNW_004624744:11,462,847...11,467,870 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in ISO (PMID:22110751) BHF-UCL PMID:22110751 NCBI chrNW_004624753:375,163...394,402
Ensembl chrNW_004624753:375,279...384,379 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:9515964) MGI PMID:9515964 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in ISO (PMID:27107132)
(PMID:10821808), (PMID:23583836)		 BHF-UCL PMID:10821808 PMID:23583836 PMID:27107132 NCBI chrNW_004624800:5,600,215...5,619,020
Ensembl chrNW_004624800:5,600,212...5,619,004 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:16025100), (PMID:17662764), (PMID:18593716)
(PMID:26491108)
(PMID:23583836), (PMID:27107132)		 BHF-UCL PMID:16025100 PMID:17662764 PMID:18593716 PMID:23583836 PMID:26491108 More... NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531 		JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in ISO (PMID:29304157) BHF-UCL PMID:29304157 NCBI chrNW_004624748:6,358,588...6,533,217
Ensembl chrNW_004624748:6,358,180...6,533,249 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624874:4,234,640...5,359,333
Ensembl chrNW_004624874:4,949,538...5,357,690 		JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624745:800,963...2,121,445
Ensembl chrNW_004624745:804,797...1,390,551 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:26634652) BHF-UCL PMID:26634652 NCBI chrNW_004624770:10,592,304...10,731,640 JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:26634652) BHF-UCL PMID:26634652 NCBI chrNW_004624865:4,461,200...4,591,309
Ensembl chrNW_004624865:4,461,215...4,588,836 		JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624755:11,470,810...11,819,800
Ensembl chrNW_004624755:11,472,377...11,819,266 		JBrowse link
G Slit3 slit guidance ligand 3 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624733:20,683,680...21,293,663
Ensembl chrNW_004624733:20,683,814...21,291,088 		JBrowse link
G Smad2 SMAD family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624778:11,380,656...11,460,566
Ensembl chrNW_004624778:11,384,769...11,501,078 		JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (PMID:22275001) BHF-UCL PMID:22275001 NCBI chrNW_004624781:6,043,183...6,108,959
Ensembl chrNW_004624781:6,042,904...6,107,860 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISO (PMID:22110751) BHF-UCL PMID:22110751 NCBI chrNW_004624801:2,296,353...2,300,853
Ensembl chrNW_004624801:2,296,168...2,301,596 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in ISO (PMID:18275040), (PMID:18834961) BHF-UCL PMID:18275040 PMID:18834961 NCBI chrNW_004624740:25,645,526...25,698,235
Ensembl chrNW_004624740:25,645,895...25,697,132 		JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in ISO (PMID:26634652) BHF-UCL PMID:26634652 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605 		JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 involved_in ISO (PMID:20101701) BHF-UCL PMID:20101701 NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959 		JBrowse link
G Tie1 tyrosine kinase with immunoglobulin like and EGF like domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624892:2,626,999...2,645,841
Ensembl chrNW_004624892:2,626,875...2,645,841 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:20804746) BHF-UCL PMID:20804746 NCBI chrNW_004624739:11,352,040...11,354,019
Ensembl chrNW_004624739:11,352,141...11,352,809 		JBrowse link
atrioventricular valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO (PMID:23603510) BHF-UCL PMID:23603510 NCBI chrNW_004624864:3,308,548...3,311,431
Ensembl chrNW_004624864:3,308,794...3,309,939 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:11854453) BHF-UCL PMID:11854453 NCBI chrNW_004624841:218,642...304,744
Ensembl chrNW_004624841:219,133...265,397 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (PMID:15297376) MGI PMID:15297376 NCBI chrNW_004624753:375,163...394,402
Ensembl chrNW_004624753:375,279...384,379 		JBrowse link
G Pitx2 paired like homeodomain 2 acts_upstream_of_or_within ISO (PMID:18292603) MGI PMID:18292603 NCBI chrNW_004624838:4,872,279...4,889,780
Ensembl chrNW_004624838:4,871,511...4,886,384 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in ISO (PMID:21983003) BHF-UCL PMID:21983003 NCBI chrNW_004624740:25,645,526...25,698,235
Ensembl chrNW_004624740:25,645,895...25,697,132 		JBrowse link
atrioventricular valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata4 GATA binding protein 4 involved_in ISO (PMID:21330551) BHF-UCL PMID:21330551 NCBI chrNW_004624758:25,278,878...25,319,317
Ensembl chrNW_004624758:25,278,874...25,319,318 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (PMID:17259303) BHF-UCL PMID:17259303 NCBI chrNW_004624744:11,462,865...11,466,559
Ensembl chrNW_004624744:11,462,847...11,467,870 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624778:14,570,025...14,629,950
Ensembl chrNW_004624778:14,570,348...14,630,325 		JBrowse link
atrioventricular valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624732:7,929,997...8,004,235
Ensembl chrNW_004624732:7,929,583...8,005,072 		JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within ISO (PMID:16314491) MGI PMID:16314491 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 NOT|involved_in ISO (PMID:12441304) BHF-UCL PMID:12441304 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683 		JBrowse link
G Ccn1 cellular communication network factor 1 acts_upstream_of_or_within ISO (PMID:17023674) MGI PMID:17023674 NCBI chrNW_004624742:11,882,815...11,885,686
Ensembl chrNW_004624742:11,882,907...11,885,667 		JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO (PMID:19084512) MGI PMID:19084512 NCBI chrNW_004624758:25,278,878...25,319,317
Ensembl chrNW_004624758:25,278,874...25,319,318 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (PMID:17303760) BHF-UCL PMID:17303760 NCBI chrNW_004624744:11,462,865...11,466,559
Ensembl chrNW_004624744:11,462,847...11,467,870 		JBrowse link
G Heyl hes related family bHLH transcription factor with YRPW motif like involved_in ISO (PMID:17303760) BHF-UCL PMID:17303760 NCBI chrNW_004624764:22,118,995...22,135,280
Ensembl chrNW_004624764:22,122,079...22,135,252 		JBrowse link
G Mdm4 MDM4 regulator of p53 acts_upstream_of_or_within ISO (PMID:22821713) MGI PMID:22821713 NCBI chrNW_004624807:6,480,785...6,522,149
Ensembl chrNW_004624807:6,486,333...6,522,801 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:14701881), (PMID:21266778) BHF-UCL PMID:14701881 PMID:21266778 NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531 		JBrowse link
G Slit3 slit guidance ligand 3 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624733:20,683,680...21,293,663
Ensembl chrNW_004624733:20,683,814...21,291,088 		JBrowse link
G Tbx5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19084512) Ensembl
MGI		 PMID:19084512 GO_REF:0000107 NCBI chrNW_004624747:18,307,294...18,348,040
Ensembl chrNW_004624747:18,307,294...18,348,040 		JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (PMID:9217007) BHF-UCL PMID:9217007 NCBI chrNW_004624835:2,363,059...2,436,536
Ensembl chrNW_004624835:2,363,139...2,437,643 		JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 involved_in ISO (PMID:20652948) BHF-UCL PMID:20652948 NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959 		JBrowse link
G Zfpm1 zinc finger protein, FOG family member 1 involved_in ISO (PMID:14614148) BHF-UCL PMID:14614148 NCBI chrNW_004624746:988,114...1,035,697
Ensembl chrNW_004624746:988,512...1,017,652 		JBrowse link
cell proliferation involved in heart valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:20804746) BHF-UCL PMID:20804746 NCBI chrNW_004624739:11,352,040...11,354,019
Ensembl chrNW_004624739:11,352,141...11,352,809 		JBrowse link
coronary sinus valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531 		JBrowse link
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna1 ephrin A1 involved_in ISO (PMID:20960543) BHF-UCL PMID:20960543 NCBI chrNW_004624885:2,382,712...2,388,805
Ensembl chrNW_004624885:2,383,045...2,389,107 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:15680351) MGI PMID:15680351 NCBI chrNW_004624744:11,462,865...11,466,559
Ensembl chrNW_004624744:11,462,847...11,467,870 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (PMID:15680351) MGI PMID:15680351 NCBI chrNW_004624753:375,163...394,402
Ensembl chrNW_004624753:375,279...384,379 		JBrowse link
heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scx scleraxis bHLH transcription factor involved_in ISO (PMID:18802027) UniProt PMID:18802027 NCBI chrNW_004624735:12,579,963...12,583,128
Ensembl chrNW_004624735:12,579,956...12,581,736 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (PMID:17350610) MGI PMID:17350610 NCBI chrNW_004624801:2,296,353...2,300,853
Ensembl chrNW_004624801:2,296,168...2,301,596 		JBrowse link
heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif 9 involved_in ISO (PMID:20096780) BHF-UCL PMID:20096780 NCBI chrNW_004624888:1,333,534...1,474,776
Ensembl chrNW_004624888:1,333,714...1,474,897 		JBrowse link
G Fam114a1 family with sequence similarity 114 member A1 acts_upstream_of_or_within ISO (PMID:35671117) MGI PMID:35671117 NCBI chrNW_004624840:7,352,552...7,423,520
Ensembl chrNW_004624840:7,352,539...7,423,520 		JBrowse link
G Fgfrl1 fibroblast growth factor receptor like 1 acts_upstream_of_or_within ISO (PMID:19383940) MGI PMID:19383940 NCBI chrNW_004624755:26,134,957...26,145,746
Ensembl chrNW_004624755:26,135,505...26,144,325 		JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within ISO (PMID:25139234) MGI PMID:25139234 NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:9515963) MGI PMID:9515963 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
G Scx scleraxis bHLH transcription factor involved_in ISO (PMID:18802027) UniProt PMID:18802027 NCBI chrNW_004624735:12,579,963...12,583,128
Ensembl chrNW_004624735:12,579,956...12,581,736 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (PMID:17350610) MGI PMID:17350610 NCBI chrNW_004624801:2,296,353...2,300,853
Ensembl chrNW_004624801:2,296,168...2,301,596 		JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in ISO (PMID:8009224) BHF-UCL PMID:8009224 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605 		JBrowse link
G Tgfb2 transforming growth factor beta 2 acts_upstream_of_or_within
involved_in		 ISO (PMID:21780244)
(PMID:11390347)		 MGI
BHF-UCL		 PMID:11390347 PMID:21780244 NCBI chrNW_004624835:2,363,059...2,436,536
Ensembl chrNW_004624835:2,363,139...2,437,643 		JBrowse link
mitral valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
mitral valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dchs1 dachsous cadherin-related 1 involved_in ISO (PMID:26258302) UniProt PMID:26258302 NCBI chrNW_004624817:8,111,714...8,147,699
Ensembl chrNW_004624817:8,111,718...8,134,342 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:16025100) BHF-UCL PMID:16025100 NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531 		JBrowse link
G Zfpm1 zinc finger protein, FOG family member 1 involved_in ISO (PMID:14614148) BHF-UCL PMID:14614148 NCBI chrNW_004624746:988,114...1,035,697
Ensembl chrNW_004624746:988,512...1,017,652 		JBrowse link
mitral valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624732:7,929,997...8,004,235
Ensembl chrNW_004624732:7,929,583...8,005,072 		JBrowse link
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif 19 involved_in ISO (PMID:31844321) BHF-UCL PMID:31844321 NCBI chrNW_004624774:11,631,446...11,900,692
Ensembl chrNW_004624774:11,631,376...11,900,121 		JBrowse link
G Axin2 axin 2 involved_in ISO (PMID:28069701) BHF-UCL PMID:28069701 NCBI chrNW_004624870:2,803,743...2,832,489
Ensembl chrNW_004624870:2,800,873...2,832,626 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:16037571) BHF-UCL PMID:16037571 NCBI chrNW_004624841:218,642...304,744
Ensembl chrNW_004624841:219,133...265,397 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:19409885) BHF-UCL PMID:19409885 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683 		JBrowse link
G Dchs1 dachsous cadherin-related 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:26258302) MGI PMID:26258302 NCBI chrNW_004624817:8,111,714...8,147,699
Ensembl chrNW_004624817:8,111,718...8,134,342 		JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:20960543) BHF-UCL PMID:20960543 NCBI chrNW_004624885:2,382,712...2,388,805
Ensembl chrNW_004624885:2,383,045...2,389,107 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO (PMID:26147524) MGI PMID:26147524 NCBI chrNW_004624795:1,553,582...1,558,110
Ensembl chrNW_004624795:1,553,037...1,558,197 		JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (PMID:10655064) BHF-UCL PMID:10655064 NCBI chrNW_004624781:6,043,183...6,108,959
Ensembl chrNW_004624781:6,042,904...6,107,860 		JBrowse link
G Sox4 SRY-box transcription factor 4 involved_in ISO (PMID:16109771) BHF-UCL PMID:16109771 NCBI chrNW_004624756:5,128,848...5,156,174 JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:20804746) BHF-UCL PMID:20804746 NCBI chrNW_004624739:11,352,040...11,354,019
Ensembl chrNW_004624739:11,352,141...11,352,809 		JBrowse link
negative regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:19409885) BHF-UCL PMID:19409885 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531 		JBrowse link
positive regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624778:14,570,025...14,629,950
Ensembl chrNW_004624778:14,570,348...14,630,325 		JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:20804746) BHF-UCL PMID:20804746 NCBI chrNW_004624739:11,352,040...11,354,019
Ensembl chrNW_004624739:11,352,141...11,352,809 		JBrowse link
pulmonary valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:12441304) BHF-UCL PMID:12441304 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 involved_in ISO (PMID:22300732) BHF-UCL PMID:22300732 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624755:6,176,497...6,298,034
Ensembl chrNW_004624755:6,176,497...6,298,225 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624860:3,111,244...3,123,041
Ensembl chrNW_004624860:3,111,630...3,122,711 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO (PMID:26491108) BHF-UCL PMID:26491108 NCBI chrNW_004624818:894,470...922,806
Ensembl chrNW_004624818:896,150...922,710 		JBrowse link
pulmonary valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in ISO (PMID:15843409) BHF-UCL PMID:15843409 NCBI chrNW_004624740:25,645,526...25,698,235
Ensembl chrNW_004624740:25,645,895...25,697,132 		JBrowse link
pulmonary valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif 19 involved_in ISO (PMID:32323311) BHF-UCL PMID:32323311 NCBI chrNW_004624774:11,631,446...11,900,692
Ensembl chrNW_004624774:11,631,376...11,900,121 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 involved_in ISO (PMID:23531444) BHF-UCL PMID:23531444 NCBI chrNW_004624745:14,890,111...14,934,972
Ensembl chrNW_004624745:14,896,340...14,935,016 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:15070745), (PMID:18924235) BHF-UCL PMID:15070745 PMID:18924235 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (PMID:17303760) BHF-UCL PMID:17303760 NCBI chrNW_004624744:11,462,865...11,466,559
Ensembl chrNW_004624744:11,462,847...11,467,870 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in ISO (PMID:12372254) BHF-UCL PMID:12372254 NCBI chrNW_004624753:375,163...394,402
Ensembl chrNW_004624753:375,279...384,379 		JBrowse link
G Heyl hes related family bHLH transcription factor with YRPW motif like involved_in ISO (PMID:17303760) BHF-UCL PMID:17303760 NCBI chrNW_004624764:22,118,995...22,135,280
Ensembl chrNW_004624764:22,122,079...22,135,252 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in ISO (PMID:20437614), (PMID:9207787) BHF-UCL PMID:9207787 PMID:20437614 NCBI chrNW_004624741:11,647,723...11,683,137
Ensembl chrNW_004624741:11,647,463...11,683,488 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:9515964) MGI PMID:9515964 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in ISO (PMID:27107132) BHF-UCL PMID:27107132 NCBI chrNW_004624800:5,600,215...5,619,020
Ensembl chrNW_004624800:5,600,212...5,619,004 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:16025100)
(PMID:26491108)
(PMID:27107132)		 BHF-UCL PMID:16025100 PMID:26491108 PMID:27107132 NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531 		JBrowse link
G Notch2 notch receptor 2 involved_in ISO (PMID:16773578) BHF-UCL PMID:16773578 NCBI chrNW_004624772:15,572,350...15,726,312
Ensembl chrNW_004624772:15,571,998...15,726,426 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624874:4,234,640...5,359,333
Ensembl chrNW_004624874:4,949,538...5,357,690 		JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624745:800,963...2,121,445
Ensembl chrNW_004624745:804,797...1,390,551 		JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO (PMID:25691540) BHF-UCL PMID:25691540 NCBI chrNW_004624755:11,470,810...11,819,800
Ensembl chrNW_004624755:11,472,377...11,819,266 		JBrowse link
G Smad2 SMAD family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624778:11,380,656...11,460,566
Ensembl chrNW_004624778:11,384,769...11,501,078 		JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (PMID:10655064) BHF-UCL PMID:10655064 NCBI chrNW_004624781:6,043,183...6,108,959
Ensembl chrNW_004624781:6,042,904...6,107,860 		JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) DFLAT PMID:17273977 NCBI chrNW_004624781:304,890...413,655
Ensembl chrNW_004624781:389,481...413,728 		JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (PMID:9217007) BHF-UCL PMID:9217007 NCBI chrNW_004624835:2,363,059...2,436,536
Ensembl chrNW_004624835:2,363,139...2,437,643 		JBrowse link
semi-lunar valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:12441304), (PMID:19409885) BHF-UCL PMID:12441304 PMID:19409885 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 involved_in ISO (PMID:22300732) BHF-UCL PMID:22300732 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
sinoatrial valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shox2 SHOX homeobox 2 involved_in ISO (PMID:19166829) BHF-UCL PMID:19166829 NCBI chrNW_004624730:35,826,631...35,836,141
Ensembl chrNW_004624730:35,825,922...35,835,756 		JBrowse link
sinoatrial valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C involved_in ISO (PMID:16680724) UniProt PMID:16680724 NCBI chrNW_004624743:8,072,871...8,235,174
Ensembl chrNW_004624743:8,072,673...8,235,252 		JBrowse link
tricuspid valve development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbx20 T-box transcription factor 20 involved_in ISO (PMID:15843409) BHF-UCL PMID:15843409 NCBI chrNW_004624740:25,645,526...25,698,235
Ensembl chrNW_004624740:25,645,895...25,697,132 		JBrowse link
tricuspid valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (PMID:15297376) MGI PMID:15297376 NCBI chrNW_004624753:375,163...394,402
Ensembl chrNW_004624753:375,279...384,379 		JBrowse link
G Zfpm1 zinc finger protein, FOG family member 1 involved_in ISO (PMID:14614148) BHF-UCL PMID:14614148 NCBI chrNW_004624746:988,114...1,035,697
Ensembl chrNW_004624746:988,512...1,017,652 		JBrowse link
tricuspid valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif 19 involved_in ISO (PMID:32323311) BHF-UCL PMID:32323311 NCBI chrNW_004624774:11,631,446...11,900,692
Ensembl chrNW_004624774:11,631,376...11,900,121 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:16037571) BHF-UCL PMID:16037571 NCBI chrNW_004624841:218,642...304,744
Ensembl chrNW_004624841:219,133...265,397 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:19409885) BHF-UCL PMID:19409885 NCBI chrNW_004624765:13,849,689...13,950,839
Ensembl chrNW_004624765:13,857,062...13,947,683 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in ISO (PMID:12372254) BHF-UCL PMID:12372254 NCBI chrNW_004624753:375,163...394,402
Ensembl chrNW_004624753:375,279...384,379 		JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 involved_in ISO (PMID:20652948) BHF-UCL PMID:20652948 NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15172
    developmental process 6226
      anatomical structure development 5855
        heart valve development 68
          atrioventricular valve development + 29
          cell proliferation involved in heart valve development + 4
          coronary sinus valve development + 1
          heart valve cell differentiation 0
          heart valve morphogenesis + 57
          semi-lunar valve development + 44
          sinoatrial valve development + 2
          ventriculo bulbo valve development + 0
Path 2
Term Annotations click to browse term
  biological_process 15172
    developmental process 6226
      anatomical structure development 5855
        multicellular organism development 4746
          system development 4144
            circulatory system development 1200
              heart development 690
                heart valve development 68
                  atrioventricular valve development + 29
                  cell proliferation involved in heart valve development + 4
                  coronary sinus valve development + 1
                  heart valve cell differentiation 0
                  heart valve morphogenesis + 57
                  semi-lunar valve development + 44
                  sinoatrial valve development + 2
                  ventriculo bulbo valve development + 0
paths to the root