Pde2a (phosphodiesterase 2A) - Rat Genome Database

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Gene: Pde2a (phosphodiesterase 2A) Heterocephalus glaber
Analyze
Symbol: Pde2a
Name: phosphodiesterase 2A
RGD ID: 18911423
Description: ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); aorta development (ortholog); cardiac septum development (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,269,347 - 4,369,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
aorta development  (ISO)
cardiac septum development  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (ISO)
cellular response to cAMP  (ISO)
cellular response to cGMP  (ISS)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISS)
cellular response to lipopolysaccharide  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (ISS)
cellular response to mechanical stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cGMP catabolic process  (ISS)
cGMP-mediated signaling  (ISS)
coronary vasculature development  (ISO)
establishment of endothelial barrier  (ISO)
heart development  (ISO)
heart valve development  (ISO)
intracellular signal transduction  (ISO)
monocyte differentiation  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISS)
negative regulation of cAMP/PKA signal transduction  (ISO)
negative regulation of cGMP-mediated signaling  (ISO)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISS)
negative regulation of vascular permeability  (ISS)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of vascular permeability  (ISS)
regulation of cGMP-mediated signaling  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of nitric oxide mediated signal transduction  (ISO)
response to hydrogen sulfide  (ISO)
signal transduction  (IEA)
ventricular septum development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Pde2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,269,347 - 4,369,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PDE2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,576,141 - 72,674,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,576,141 - 72,674,591 (-)EnsemblGRCh38hg38GRCh38
GRCh371172,287,185 - 72,385,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,964,833 - 72,063,060 (-)NCBINCBI36Build 36hg18NCBI36
Build 341171,964,833 - 72,063,060NCBI
Celera1169,589,446 - 69,690,059 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBIHuRef
CHM1_11172,170,508 - 72,268,807 (-)NCBICHM1_1
T2T-CHM13v2.01172,502,658 - 72,602,659 (-)NCBIT2T-CHM13v2.0
Pde2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,070,905 - 101,162,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,070,898 - 101,162,034 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl7101,060,093 - 101,162,026 (+)EnsemblGRCm39 Ensembl
GRCm387101,421,691 - 101,512,829 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,410,886 - 101,512,819 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,421,691 - 101,512,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv377108,570,212 - 108,661,341 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,295,530 - 101,386,636 (+)NCBIMGSCv36mm8
Celera7101,780,588 - 101,872,064 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.57NCBI
Pde2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,235,623 - 165,327,466 (+)NCBIGRCr8
mRatBN7.21155,823,590 - 155,915,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,813,180 - 155,915,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,808,496 - 163,900,427 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,988,582 - 171,080,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,872,593 - 163,964,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
Pde2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,735,822 - 18,827,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,765,591 - 18,826,717 (+)NCBIChiLan1.0ChiLan1.0
PDE2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2973,521,727 - 73,621,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,565,189 - 74,665,355 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,653,335 - 67,753,450 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11170,875,552 - 70,975,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,875,552 - 70,975,322 (-)Ensemblpanpan1.1panPan2
PDE2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,542,030 - 25,635,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2125,542,268 - 25,635,660 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,314,283 - 25,406,213 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,751,755 - 25,844,665 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,751,765 - 25,844,666 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12125,544,034 - 25,636,601 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,747,386 - 25,839,981 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02125,660,737 - 25,753,526 (+)NCBIUU_Cfam_GSD_1.0
Pde2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,256,724 - 60,344,873 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,856,144 - 1,944,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,856,256 - 1,944,405 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,136,637 - 7,227,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,896,906 - 7,988,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,812,877 - 63,912,602 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,812,840 - 63,880,492 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,969,532 - 62,070,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000013758   ⟹   ENSHGLP00000013617
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248174,269,347 - 4,369,486 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000013759   ⟹   ENSHGLP00000013618
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248174,304,220 - 4,366,532 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000013760   ⟹   ENSHGLP00000013619
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248174,312,999 - 4,369,486 (+)Ensembl
RefSeq Acc Id: XM_004863295   ⟹   XP_004863352
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBI
RefSeq Acc Id: XM_021243217   ⟹   XP_021098876
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248174,335,834 - 4,367,576 (+)NCBI
RefSeq Acc Id: XM_021243218   ⟹   XP_021098877
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248174,304,559 - 4,367,576 (+)NCBI
RefSeq Acc Id: XM_021243219   ⟹   XP_021098878
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248174,313,551 - 4,367,576 (+)NCBI
RefSeq Acc Id: XM_021243220   ⟹   XP_021098879
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBI
RefSeq Acc Id: XM_021243221   ⟹   XP_021098880
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248174,304,843 - 4,367,576 (+)NCBI
RefSeq Acc Id: XP_021098879   ⟸   XM_021243220
- Peptide Label: isoform X5
- UniProtKB: A0A0N8EUM7 (UniProtKB/TrEMBL),   G5AS68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004863352   ⟸   XM_004863295
- Peptide Label: isoform X3
- UniProtKB: G5AS68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098877   ⟸   XM_021243218
- Peptide Label: isoform X2
- UniProtKB: G5AS68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098880   ⟸   XM_021243221
- Peptide Label: isoform X5
- UniProtKB: A0A0N8EUM7 (UniProtKB/TrEMBL),   G5AS68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098878   ⟸   XM_021243219
- Peptide Label: isoform X4
- UniProtKB: G5AS68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098876   ⟸   XM_021243217
- Peptide Label: isoform X1
- UniProtKB: G5AS68 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000013619   ⟸   ENSHGLT00000013760
Ensembl Acc Id: ENSHGLP00000013617   ⟸   ENSHGLT00000013758
Ensembl Acc Id: ENSHGLP00000013618   ⟸   ENSHGLT00000013759


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009736 Ensembl, ENTREZGENE
  ENSHGLG00100013119 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000013758 ENTREZGENE
  ENSHGLT00000013759 ENTREZGENE
  ENSHGLT00000013760 ENTREZGENE
  ENSHGLT00100017977 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/TrEMBL
InterPro GAF UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene Pde2a ENTREZGENE
PANTHER 3',5'-CYCLIC PHOSPHODIESTERASE PDE-2-RELATED UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam GAF UniProtKB/TrEMBL
  GAF_2 UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART GAF UniProtKB/TrEMBL
  HDc UniProtKB/TrEMBL
Superfamily-SCOP GAF domain-like UniProtKB/TrEMBL
  HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0A0N8EUM7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PZP1_HETGA UniProtKB/TrEMBL
  A0AAX6RM19_HETGA UniProtKB/TrEMBL
  A0AAX6RNI9_HETGA UniProtKB/TrEMBL
  A0AAX6RSW2_HETGA UniProtKB/TrEMBL
  G5AS68 ENTREZGENE, UniProtKB/TrEMBL