Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:syphilis
go back to main search page
Accession:DOID:4166 term browser browse the term
Definition:A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. (DO)
Synonyms:exact_synonym: chancre;   chancres;   great pox;   syphilitic chancre
 primary_id: MESH:D013587
 alt_id: MESH:D002601
 xref: EFO:0007504;   EFO:1001247;   ICD10CM:A51.0
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
syphilis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 ISO RGD PMID:18008231 RGD:8551830 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Foxp3 forkhead box P3 treatment ISO RGD PMID:27284313 RGD:38456006 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Nefl neurofilament light chain ISO associated with age;protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO associated with age;protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
Neurosyphilis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nefl neurofilament light chain disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease by infectious agent 2211
      Bacterial Infections and Mycoses 1072
        bacterial infectious disease 823
          primary bacterial infectious disease 196
            syphilis 5
              Cutaneous Syphilis 0
              Neurosyphilis + 3
              cardiovascular syphilis 0
              congenital syphilis + 0
              latent syphilis 0
              primary syphilis 0
              secondary syphilis 0
              tertiary syphilis + 1
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      Urogenital Diseases 5218
        Female Urogenital Diseases and Pregnancy Complications 2432
          Female Urogenital Diseases 1981
            female reproductive system disease 1978
              Sexually Transmitted Diseases 235
                Bacterial Sexually Transmitted Diseases 20
                  syphilis 5
                    Cutaneous Syphilis 0
                    Neurosyphilis + 3
                    cardiovascular syphilis 0
                    congenital syphilis + 0
                    latent syphilis 0
                    primary syphilis 0
                    secondary syphilis 0
                    tertiary syphilis + 1
paths to the root