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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:syphilis
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Accession:DOID:4166 term browser browse the term
Definition:A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. (DO)
Synonyms:exact_synonym: chancre;   chancres;   great pox;   syphilitic chancre
 primary_id: MESH:D013587
 alt_id: MESH:D002601
 xref: EFO:0007504;   EFO:1001247;   ICD10CM:A51.0
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
syphilis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 ISO RGD PMID:18008231 RGD:8551830 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Foxp3 forkhead box P3 treatment ISO RGD PMID:27284313 RGD:38456006 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Nefl neurofilament light chain ISO associated with age;protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO associated with age;protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
Neurosyphilis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nefl neurofilament light chain disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21147
    disease by infectious agent 2213
      Bacterial Infections and Mycoses 1072
        bacterial infectious disease 823
          primary bacterial infectious disease 196
            syphilis 5
              Cutaneous Syphilis 0
              Neurosyphilis + 3
              cardiovascular syphilis 0
              congenital syphilis + 0
              latent syphilis 0
              primary syphilis 0
              secondary syphilis 0
              tertiary syphilis + 1
Path 2
Term Annotations click to browse term
  disease 21147
    disease of anatomical entity 18195
      Urogenital Diseases 5185
        Female Urogenital Diseases and Pregnancy Complications 2419
          Female Urogenital Diseases 1971
            female reproductive system disease 1968
              Sexually Transmitted Diseases 234
                Bacterial Sexually Transmitted Diseases 20
                  syphilis 5
                    Cutaneous Syphilis 0
                    Neurosyphilis + 3
                    cardiovascular syphilis 0
                    congenital syphilis + 0
                    latent syphilis 0
                    primary syphilis 0
                    secondary syphilis 0
                    tertiary syphilis + 1
paths to the root