RGD Reference Report - Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis. - Rat Genome Database

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Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis.

Authors: Li, Wurong  Chang, Haoxiao  Wu, Wenqing  Xu, Dongmei  Jiang, Meijuan  Gao, Junhua  Huang, Yuming  Xu, Yun  Yin, Linlin  Zhang, Xinghu 
Citation: Li W, etal., Front Neurol. 2020 Feb 5;11:62. doi: 10.3389/fneur.2020.00062. eCollection 2020.
RGD ID: 127285386
Pubmed: PMID:32117023   (View Abstract at PubMed)
PMCID: PMC7013092   (View Article at PubMed Central)
DOI: DOI:10.3389/fneur.2020.00062   (Journal Full-text)

Objective: To explore cerebrospinal fluid (CSF) levels of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) and neurofilament light proteins (NFL) in patients with neurosyphilis (NS). Methods: We enrolled 71 NS patients (41 early-NS and 30 late-NS patients) and 20 syphilis but non-NS patients whose CSF samples were collected. The CSF levels of the microglial activation biomarker sTREM2 and neuronal injury biomarker NFL were measured using ELISA. Results: CSF sTREM2 levels were significantly higher in NS patients compared to those in syphilis/non-NS patients (p < 0.001). In a subgroup analysis, the CSF sTREM2 levels elevated significantly in late-NS patients than those in early-NS patients (p < 0.001). The CSF sTREM2 levels in early-NS group were also significantly higher than those in syphilis/non-NS group (p = 0.024). Like CSF sTREM2, similar differences between groups were also found in CSF NFL. There was a moderate correlation between CSF sTREM2 and CSF NFL (r = 0.406, p < 0.001) in NS group. Conclusions: CSF sTREM2 levels elevated in NS and peaked at the late stage, suggesting that CSF sTREM2 may be a useful marker to quantify microglia activation in NS and may play a role in the progression of NS. The positive correlation between CSF sTREM2 and CSF NFL indicates a linkage between microglial activation and neuronal injury in NS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neurosyphilis disease_progressionIEP 127285386; 127285386protein:increased expression:CSF (human)RGD 
Neurosyphilis disease_progressionISONEFL (Homo sapiens)127285386; 127285386protein:increased expression:CSF (human)RGD 
Neurosyphilis disease_progressionISOTREM2 (Homo sapiens)127285386; 127285386protein:increased expression:CSF (human)RGD 
syphilis  IEP 127285386; 127285386associated with age and protein:increased expression:CSF (human)RGD 
syphilis  ISONEFL (Homo sapiens)127285386; 127285386associated with age and protein:increased expression:CSF (human)RGD 
syphilis  ISOTREM2 (Homo sapiens)127285386; 127285386associated with age and protein:increased expression:CSF (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nefl  (neurofilament light chain)
Trem2  (triggering receptor expressed on myeloid cells 2)

Genes (Mus musculus)
Nefl  (neurofilament, light polypeptide)
Trem2  (triggering receptor expressed on myeloid cells 2)

Genes (Homo sapiens)
NEFL  (neurofilament light chain)
TREM2  (triggering receptor expressed on myeloid cells 2)


Additional Information