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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:limb ischemia
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Accession:DOID:0050852 term browser browse the term
Definition:An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply. (DO)


show annotations for term's descendants           Sort by:
limb ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 ISO RGD PMID:26315408 RGD:14367880 NCBI chr15:36,925,443...37,038,288
Ensembl chr15:55,237,101...55,557,168 		JBrowse link
G CS citrate synthase ISO RGD PMID:571116 RGD:243049254 NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854 		JBrowse link
G CSF2 colony stimulating factor 2 ISO protein:increased expression:plasma: RGD PMID:16648859 RGD:10449511 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146 		JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO RGD PMID:16224058 PMID:23294128 RGD:10400895 RGD:11039414 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 exacerbates
ameliorates		 ISO RGD PMID:20508179 PMID:22252294 PMID:35301145 RGD:155641249 RGD:155663358 RGD:155663375 NCBI chr15:19,871,584...19,881,817
Ensembl chr15:38,121,574...38,129,471 		JBrowse link
G EPO erythropoietin treatment ISO RGD PMID:23294128 RGD:10400895 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G ETV2 ETS variant transcription factor 2 exacerbates
ameliorates		 ISO RGD PMID:26586661 PMID:28424975 PMID:28466428 PMID:32075417 RGD:11076207 RGD:156451664 RGD:192186227 RGD:192379484 NCBI chr19:32,571,829...32,575,083
Ensembl chr19:41,307,864...41,311,004 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 treatment ISO RGD PMID:25388665 RGD:11568031 NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO RGD PMID:26604244 RGD:13514042 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G HGF hepatocyte growth factor treatment ISO RGD PMID:15238569 RGD:8548639 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:skeletal muscle RGD PMID:17522350 RGD:1626332 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:12593860 RGD:1598394 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G ITGAM integrin subunit alpha M ISO protein:increased expression:monocyte (human) RGD PMID:20816321 RGD:329901827 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G ITGAV integrin subunit alpha V ISO RGD PMID:15750161 RGD:1582449 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO associated with Diabetes Mellitus, Experimental
human gene in rat model		 RGD PMID:12171788 PMID:19080171 PMID:28979692 RGD:13450931 RGD:7794710 RGD:7794776 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:21940947 PMID:22369073 RGD:6767285 RGD:6906905 NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067 		JBrowse link
G PPBP pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:30638058 RGD:401794451 NCBI chr 4:50,203,168...50,204,303
Ensembl chr 4:56,035,060...56,037,702 		JBrowse link
G PTGIS prostaglandin I2 synthase treatment ISO rat gene in human cells in a mouse model
human gene in a mouse model		 RGD PMID:12586736 PMID:14568901 PMID:19344900 RGD:401959585 RGD:401960079 RGD:401960096 NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO protein:increased expression, increased activity:hindlimb muscle (mouse) RGD PMID:18451337 RGD:401965417 NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421 		JBrowse link
G VEGFA vascular endothelial growth factor A treatment ISO RGD PMID:23562340 RGD:7421600 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
limb reperfusion injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPT glutamic--pyruvic transaminase treatment ISO RGD PMID:36495512 RGD:401717522 Ensembl chr 8:144,259,991...144,263,737 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    Pathological Conditions, Signs and Symptoms 12039
      Pathologic Processes 7439
        ischemia 1366
          limb ischemia 21
            limb reperfusion injury 1
Path 2
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15262
      cardiovascular system disease 4336
        vascular disease 3044
          ischemia 1366
            limb ischemia 21
              limb reperfusion injury 1
paths to the root