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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Arbovirus Encephalitis
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Accession:DOID:9008926 term browser browse the term
Definition:Infections of the brain caused by arthropod-borne viruses (i.e., arboviruses) primarily from the families TOGAVIRIDAE; FLAVIVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; and RHABDOVIRIDAE. Life cycles of these viruses are characterized by ZOONOSES, with birds and lower mammals serving as intermediate hosts. The virus is transmitted to humans by the bite of mosquitoes (CULICIDAE) or TICKS. Clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)
Synonyms:exact_synonym: Arbovirus Encephalitides;   Arthropod Borne Encephalitis;   Arthropod Borne Viral Encephalitis;   Arthropod-Borne Encephalitides;   Arthropod-Borne Viral Encephalitides;   Mosquito Borne Encephalitis;   Mosquito-Borne Encephalitides
 primary_id: MESH:D004671


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Japanese encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO RGD PMID:17010311 RGD:18337278 NCBI chr 6:78,730,204...78,734,232
Ensembl chr 6:78,730,206...78,733,740 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:32265853 RGD:127229907 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251 		JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
West Nile encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFIH1 interferon induced with helicase C domain 1 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr15:68,930,998...68,985,145
Ensembl chr15:68,928,254...68,985,083 		JBrowse link
G LCN2 lipocalin 2 ISO mRNA,protein:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644 		JBrowse link
G RIGI RNA sensor RIG-I ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr10:33,891,720...33,976,151
Ensembl chr10:33,891,763...33,933,455 		JBrowse link
G RNASEL ribonuclease L disease_progression ISO RGD PMID:16809306 RGD:40902815 NCBI chr 9:123,895,045...123,910,386
Ensembl chr 9:123,893,294...123,910,398 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 severity ISO RGD PMID:31415679 RGD:39128224 NCBI chr 2:141,359,402...141,367,222
Ensembl chr 2:141,358,993...141,367,198 		JBrowse link
G TLR3 toll like receptor 3 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
West Nile fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR5 C-C motif chemokine receptor 5 ISO ClinVar Annotator: match by term: West Nile virus, susceptibility to ClinVar
OMIM		 PMID:8639485 PMID:8751444 PMID:8756719 PMID:9055842 PMID:9132277 More... NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G IRF5 interferon regulatory factor 5 disease_progression ISO RGD PMID:25031348 RGD:40924561 NCBI chr18:19,678,377...19,691,154
Ensembl chr18:19,678,687...19,691,243 		JBrowse link
G MAVS mitochondrial antiviral signaling protein severity ISO RGD PMID:28094802 RGD:40903045 NCBI chr17:31,850,646...31,869,273
Ensembl chr17:31,850,900...31,869,188 		JBrowse link
G RFC1 replication factor C subunit 1 susceptibility ISO DNA:silent mutation:CDS:p.P847P (rs2066786) (human) RGD PMID:21881118 RGD:41410434 NCBI chr 8:30,552,369...30,635,932
Ensembl chr 8:30,552,400...30,635,867 		JBrowse link
G S100B S100 calcium binding protein B ISO RGD PMID:19790244 RGD:5508797
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15399
    disease by infectious agent 2129
      viral infectious disease 1643
        Arbovirus Infections 54
          Arbovirus Encephalitis 15
            Eastern equine encephalitis 0
            Japanese encephalitis 2
            La Crosse encephalitis 0
            St. Louis encephalitis 0
            West Nile fever + 11
            tick-borne encephalitis + 2
Path 2
Term Annotations click to browse term
  disease 15399
    disease of anatomical entity 15091
      nervous system disease 13242
        central nervous system disease 11821
          brain disease 11102
            encephalitis 141
              Infectious Encephalitis 119
                viral encephalitis 119
                  Arbovirus Encephalitis 15
                    Eastern equine encephalitis 0
                    Japanese encephalitis 2
                    La Crosse encephalitis 0
                    St. Louis encephalitis 0
                    West Nile fever + 11
                    tick-borne encephalitis + 2
paths to the root