RGD Reference Report - Soluble CD40 and soluble CD40L concentrations in the serum and the cerebrospinal fluid of patients with tick borne encephalitis and neuroborreliosis - Rat Genome Database

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Soluble CD40 and soluble CD40L concentrations in the serum and the cerebrospinal fluid of patients with tick borne encephalitis and neuroborreliosis

Authors: Zajkowska, JM  Kondrusik, M  Pancewicz, S  Swierzbinska, R  Grygorczuk, S  Hermanowska-Szpakowicz, T 
Citation: Zajkowska JM, etal., Neurol Neurochir Pol. 2006 Jan-Feb;40(1):22-7.
RGD ID: 11352252
Pubmed: PMID:16463218   (View Abstract at PubMed)

BACKGROUND AND PURPOSE: The interaction between CD40 and CD40L is essential in generating of an immunological response also intrathecally. The aim of the study was estimation of a concentration soluble form of CD40, CD40L (CD154) in the bacterial and viral inflammation of the central nervous system in two compartments - blood circulation and intrathecally, before and after the treatment. MATERIAL AND METHODS: sCD40 and sCD40L were tested twice before and after treatment in pairs serum and CSF of 40 patients treated in the Dept. of Infectious Diseases and Neuroinfections. Patients were divided in two groups: (n=20) patients with tick borne encephalitis (TBE) (group I, n=20) and patients with neuroborreliosis in the form of lymphocytic meningitis (group II, n=20). ELISA assays were performed. RESULTS: Significantly increased concentrations of sCD40, sCD40L in CSF (higher in neuroborreliosis) were measured. We found also an increased concentration of sCD40L in inflammatory CSF in both tested groups (in neuroboreliosis lasting also after 4 weeks of treatment), compared with the control group (below the detection limit in normal CSF). CONCLUSIONS: Results of estimation of the sCD40 and sCD40L concentrations indicate their role in the intrathecal inflammation process of bacterial and viral etiology. The increased serum concentration of sCD40L in TBE and CD40 in neuroborreliosis indicate that peripheral activation of the immunological system persists after cessation of treatment and after the clinical recovery. The defense mechanisms are more pronounced in neuroborreliosis than in tick borne encephalitis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD40HumanLyme Neuroborreliosis  IEP protein:increased expression:cerebrospinal fluid (human)RGD 
CD40LGHumanLyme Neuroborreliosis  IEP protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40MouseLyme Neuroborreliosis  ISORGD:1604657protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40RatLyme Neuroborreliosis  ISORGD:1604657protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40lgRatLyme Neuroborreliosis  ISORGD:1352959protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40lgMouseLyme Neuroborreliosis  ISORGD:1352959protein:increased expression:cerebrospinal fluid (human)RGD 
CD40Humantick-borne encephalitis  IEP protein:increased expression:cerebrospinal fluid (human)RGD 
CD40LGHumantick-borne encephalitis  IEP protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40Rattick-borne encephalitis  ISORGD:1604657protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40Mousetick-borne encephalitis  ISORGD:1604657protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40lgRattick-borne encephalitis  ISORGD:1352959protein:increased expression:cerebrospinal fluid (human)RGD 
Cd40lgMousetick-borne encephalitis  ISORGD:1352959protein:increased expression:cerebrospinal fluid (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40  (CD40 molecule)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40  (CD40 antigen)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40  (CD40 molecule)
CD40LG  (CD40 ligand)


Additional Information