Chronic Allograft Dysfunction - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Chronic Allograft Dysfunction	go back to main search page
Accession:	DOID:9002153	browse the term
Definition:	Chronic and progressive pathophysiological changes associated with solid organ transplantation.
Synonyms:	exact_synonym:	CAD

show annotations for term's descendants Sort by:
Rat (28) Mouse (28) Human (28) Chinchilla (26) Bonobo (27) Dog (28) Squirrel (25) Pig (28) Green Monkey (28) Naked Mole-rat (26) All
Genes (28)

Chronic Allograft Dysfunction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end-product specific receptor

treatment

PMID:22217518 PMID:23769041

RGD:7245568 RGD:8695995

NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129

G

complement C3

treatment

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

CD40 molecule

treatment

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD40 ligand

treatment

liver

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

coagulation factor VII

treatment

human protein in a rat model

NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024

G

high mobility group box 1

treatment

NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165

G

potassium calcium-activated channel subfamily N member 4

ameliorates

NCBI chr 1:111,391,464...111,407,612
Ensembl chr 1:111,391,159...111,407,701

G

mechanistic target of rapamycin kinase

treatment

NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114

G

tumor necrosis factor

treatment

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

Cardiac Allograft Vasculopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coagulation factor III, tissue factor

NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607

G

heterogeneous nuclear ribonucleoprotein K

NCBI chr 1:75,499,334...75,511,525
Ensembl chr 1:75,499,393...75,511,425

G

platelet derived growth factor D

NCBI chr 5:27,863,739...28,092,376
Ensembl chr 5:27,863,591...28,089,936

Chronic Allograft Nephropathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

NCBI chr11:49,699,072...49,758,783
Ensembl chr11:49,699,109...49,923,257

G

albumin

disease_progression

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

cellular communication network factor 2

disease_progression

mRNA, protein:increased expression:kidney (rat)

NCBI chr 1:25,508,082...25,511,058
Ensembl chr 1:25,507,662...25,510,145

G

clusterin

treatment

NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563

G

citrate synthase

treatment

NCBI chr10:584,000...611,351
Ensembl chr10:584,904...611,436

G

chemokine (C-C motif) ligand 3

NCBI chr 9:37,708,561...37,710,209
Ensembl chr 9:37,676,966...37,710,209

G

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222

G

matrix metallopeptidase 7

treatment

NCBI chr 5:29,187,902...29,196,157
Ensembl chr 5:29,187,851...29,196,153

G

platelet derived growth factor subunit A

NCBI chr 6:16,271,082...16,293,246
Ensembl chr 6:16,270,104...16,292,396

G

platelet derived growth factor subunit B

mRNA:increased expression:kidney:

PMID:11889420 PMID:15785371

RGD:10449491 RGD:11080974

NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746

G

platelet derived growth factor receptor alpha

NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278

G

platelet derived growth factor receptor beta

NCBI chr 4:58,925,922...58,963,639
Ensembl chr 4:58,926,351...58,962,283

G

plasminogen activator, urokinase

protein:increased secretion:T lymphocyte (human)

NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851

G

peroxisome proliferator activated receptor gamma

protein:increased expression:kidney:

NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981

G

serpin family E member 1

treatment

protein:increased expression:kidney:

PMID:16221712 PMID:18192922

RGD:13208600 RGD:13208601

NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301

Chronic Lung Allograft Dysfunction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelial PAS domain protein 1

mRNA:increased expression:lung

NCBI chr10:48,550,836...48,636,776
Ensembl chr10:48,551,410...48,634,844

Term paths to the root

Path 1
Term	Annotations
disease	15728
disease of anatomical entity	15372
immune system disease	4611
Transplant Rejection	122
Chronic Allograft Dysfunction	28
Cardiac Allograft Vasculopathy	3
Chronic Allograft Nephropathy	15
Chronic Lung Allograft Dysfunction	1
Path 2
Term	Annotations
disease	15728
disease of anatomical entity	15372
cardiovascular system disease	4539
vascular disease	3116
ischemia	1429
Reperfusion Injury	778
Chronic Allograft Dysfunction	28
Cardiac Allograft Vasculopathy	3
Chronic Allograft Nephropathy	15
Chronic Lung Allograft Dysfunction	1

paths to the root