CS (citrate synthase) - Rat Genome Database

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Gene: CS (citrate synthase) Canis lupus familiaris
Analyze
Symbol: CS
Name: citrate synthase
RGD ID: 12313293
Description: ENCODES a protein that exhibits citrate (Si)-synthase activity (ortholog); citrate synthase activity (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); citrate metabolic process (ortholog); heart development (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH atrial fibrillation (ortholog); bipolar disorder (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: canopy 2 homolog; canopy FGF signaling regulator 2; citrate synthase, mitochondrial; CNPY2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110584,000 - 611,351 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10584,904 - 611,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10647,257 - 674,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010592,484 - 620,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10592,484 - 620,005 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110569,926 - 597,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010812,910 - 840,419 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010937,007 - 964,321 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16751257   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110584,000 - 611,351 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10584,904 - 611,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10647,257 - 674,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010592,484 - 620,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10592,484 - 620,005 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110569,926 - 597,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010812,910 - 840,419 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010937,007 - 964,321 (-)NCBIUU_Cfam_GSD_1.0
CS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,271,699 - 56,300,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,271,699 - 56,300,391 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,665,483 - 56,694,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,951,750 - 54,980,442 (-)NCBINCBI36Build 36hg18NCBI36
Celera1256,318,264 - 56,346,961 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,704,180 - 53,732,652 (-)NCBIHuRef
CHM1_11256,632,888 - 56,661,575 (-)NCBICHM1_1
T2T-CHM13v2.01256,239,343 - 56,267,970 (-)NCBIT2T-CHM13v2.0
Cs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,173,596 - 128,198,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,173,603 - 128,198,348 (+)EnsemblGRCm39 Ensembl
GRCm3810128,337,727 - 128,362,482 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,337,734 - 128,362,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,774,888 - 127,799,535 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,740,781 - 127,765,428 (+)NCBIMGSCv36mm8
Celera10130,726,084 - 130,750,750 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.53NCBI
Cs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,348,389 - 1,374,624 (+)NCBIGRCr8
mRatBN7.27758,074 - 791,421 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7758,345 - 791,421 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,522,514 - 3,550,877 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,398,497 - 5,426,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,698,983 - 5,725,551 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,752,680 - 2,778,963 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,752,680 - 2,778,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,731,092 - 2,757,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,626,181 - 1,652,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,626,180 - 1,652,197 (+)NCBI
Celera7639,242 - 663,715 (+)NCBICelera
Cytogenetic Map7q11NCBI
Cs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,881,798 - 3,893,401 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,881,798 - 3,913,044 (-)NCBIChiLan1.0ChiLan1.0
CS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,028,323 - 38,060,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,028,468 - 38,057,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,614,982 - 32,643,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,867,225 - 32,895,854 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,867,225 - 32,895,854 (+)Ensemblpanpan1.1panPan2
Cs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,165,176 - 58,193,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646678,307 - 692,777 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646676,926 - 704,988 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,666,585 - 21,700,711 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,669,778 - 21,700,737 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,162,491 - 23,186,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5p12-p13NCBI
CS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,224,667 - 52,253,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,222,724 - 52,253,307 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,729,868 - 193,761,327 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CS
264 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022424052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_531634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ403135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000000188   ⟹   ENSCAFP00000000167
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10585,392 - 604,640 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000087840   ⟹   ENSCAFP00000049199
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10584,904 - 611,436 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013633   ⟹   ENSCAFP00845010587
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10592,484 - 619,986 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013692   ⟹   ENSCAFP00845010628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10592,488 - 620,005 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013771   ⟹   ENSCAFP00845010689
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10592,490 - 619,957 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013817   ⟹   ENSCAFP00845010719
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10592,490 - 613,284 (-)Ensembl
RefSeq Acc Id: XM_022424052   ⟹   XP_022279760
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110584,000 - 602,927 (-)NCBI
Dog10K_Boxer_Tasha10647,257 - 666,182 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038487782   ⟹   XP_038343710
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110569,926 - 597,448 (-)NCBI
RefSeq Acc Id: XM_038487783   ⟹   XP_038343711
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110569,926 - 588,840 (-)NCBI
RefSeq Acc Id: XM_038549672   ⟹   XP_038405600
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010937,007 - 964,321 (-)NCBI
RefSeq Acc Id: XM_038549673   ⟹   XP_038405601
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010937,007 - 955,715 (-)NCBI
RefSeq Acc Id: XM_038613638   ⟹   XP_038469566
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010812,910 - 840,419 (-)NCBI
RefSeq Acc Id: XM_038613639   ⟹   XP_038469567
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010812,910 - 831,812 (-)NCBI
RefSeq Acc Id: XM_038679003   ⟹   XP_038534931
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010592,484 - 620,012 (-)NCBI
RefSeq Acc Id: XM_038679004   ⟹   XP_038534932
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010592,484 - 611,402 (-)NCBI
RefSeq Acc Id: XM_531634   ⟹   XP_531634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110584,000 - 611,351 (-)NCBI
Dog10K_Boxer_Tasha10647,257 - 674,790 (-)NCBI
Sequence:
RefSeq Acc Id: XP_531634   ⟸   XM_531634
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QGS7 (UniProtKB/TrEMBL),   A0A8I3RVM2 (UniProtKB/TrEMBL),   A0A8C0Q4T7 (UniProtKB/TrEMBL),   A0A8I3N305 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279760   ⟸   XM_022424052
- Peptide Label: isoform X2
- UniProtKB: A0A8C0Q4T7 (UniProtKB/TrEMBL),   A0A8I3N305 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000049199   ⟸   ENSCAFT00000087840
RefSeq Acc Id: ENSCAFP00000000167   ⟸   ENSCAFT00000000188
RefSeq Acc Id: XP_038343710   ⟸   XM_038487782
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038343711   ⟸   XM_038487783
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038469566   ⟸   XM_038613638
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469567   ⟸   XM_038613639
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038534931   ⟸   XM_038679003
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QGS7 (UniProtKB/TrEMBL),   A0A8I3RVM2 (UniProtKB/TrEMBL),   A0A8C0Q4T7 (UniProtKB/TrEMBL),   A0A8I3N305 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038534932   ⟸   XM_038679004
- Peptide Label: isoform X2
- UniProtKB: A0A8C0Q4T7 (UniProtKB/TrEMBL),   A0A8I3N305 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405600   ⟸   XM_038549672
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Q4T7 (UniProtKB/TrEMBL),   A0A8C0QGS7 (UniProtKB/TrEMBL),   A0A8I3N305 (UniProtKB/TrEMBL),   A0A8I3RVM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405601   ⟸   XM_038549673
- Peptide Label: isoform X2
- UniProtKB: A0A8C0Q4T7 (UniProtKB/TrEMBL),   A0A8I3N305 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010719   ⟸   ENSCAFT00845013817
RefSeq Acc Id: ENSCAFP00845010628   ⟸   ENSCAFT00845013692
RefSeq Acc Id: ENSCAFP00845010689   ⟸   ENSCAFT00845013771
RefSeq Acc Id: ENSCAFP00845010587   ⟸   ENSCAFT00845013633


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000115 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013773 UniProtKB/TrEMBL
  ENSCAFG00040005230 UniProtKB/TrEMBL
  ENSCAFG00845007644 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000188.5 UniProtKB/TrEMBL
  ENSCAFT00000087840.2 UniProtKB/TrEMBL
  ENSCAFT00000099686.1 UniProtKB/TrEMBL
  ENSCAFT00000105446.1 UniProtKB/TrEMBL
  ENSCAFT00030025744.1 UniProtKB/TrEMBL
  ENSCAFT00030025823.1 UniProtKB/TrEMBL
  ENSCAFT00040009917.1 UniProtKB/TrEMBL
  ENSCAFT00040009951.1 UniProtKB/TrEMBL
  ENSCAFT00845013633.1 UniProtKB/TrEMBL
  ENSCAFT00845013692.1 UniProtKB/TrEMBL
  ENSCAFT00845013771 ENTREZGENE
  ENSCAFT00845013771.1 UniProtKB/TrEMBL
  ENSCAFT00845013817 ENTREZGENE
  ENSCAFT00845013817.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.230.10 UniProtKB/TrEMBL
  1.10.580.10 UniProtKB/TrEMBL
InterPro Citrate_synth-like_lrg_a-sub UniProtKB/TrEMBL
  Citrate_synth-like_sm_a-sub UniProtKB/TrEMBL
  Citrate_synthase UniProtKB/TrEMBL
  Citrate_synthase_AS UniProtKB/TrEMBL
  Citrate_synthase_euk UniProtKB/TrEMBL
  Citrate_synthase_sf UniProtKB/TrEMBL
NCBI Gene CS ENTREZGENE
PANTHER CITRATE SYNTHASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11739 UniProtKB/TrEMBL
Pfam Citrate_synt UniProtKB/TrEMBL
PRINTS CITRTSNTHASE UniProtKB/TrEMBL
PROSITE CITRATE_SYNTHASE UniProtKB/TrEMBL
Superfamily-SCOP SSF48256 UniProtKB/TrEMBL
UniProt A0A8C0Q4T7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QGS7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N305 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N4N0_CANLF UniProtKB/TrEMBL
  A0A8I3N6V8_CANLF UniProtKB/TrEMBL
  A0A8I3RVM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T1Y0_CANLF UniProtKB/TrEMBL
  A0A8P0TQ12_CANLF UniProtKB/TrEMBL
  Q0QEK9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:49800 ENTREZGENE