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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pituitary gland benign neoplasm
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Accession:DOID:60009 term browser browse the term
Definition:A benign neoplasm located in the pituitary gland. (DO)
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
ACTH-secreting pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO ClinVar Annotator: match by term: Pituitary adenoma, acth-secreting, somatic ClinVar PMID:17360484 PMID:18381572 PMID:19366855 PMID:20506337 PMID:20530095 More... NCBI chr 2:5,042,883...5,048,885
Ensembl chr 2:5,041,990...5,048,781 		JBrowse link
G AVPR1B vasopressin receptor 1B ISO RGD PMID:23884782 RGD:14700670 NCBI chr 9:66,769,472...66,776,916
Ensembl chr 9:66,772,591...66,776,931 		JBrowse link
G BMP4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16195406 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637 		JBrowse link
G USP8 ubiquitin specific peptidase 8 ISO OMIM NCBI chr 1:121,306,031...121,376,154
Ensembl chr 1:121,306,032...121,413,223 		JBrowse link
Familial Isolated Pituitary Adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:22720333 PMID:24050928 PMID:25741868 PMID:26186299 PMID:26792934 More... NCBI chr 2:5,042,883...5,048,885
Ensembl chr 2:5,041,990...5,048,781 		JBrowse link
G ALK ALK receptor tyrosine kinase ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:9536098 PMID:17576681 PMID:21838707 PMID:22072639 PMID:23104988 More... NCBI chr 3:109,411,146...110,105,755 JBrowse link
G GNAI2 G protein subunit alpha i2 ISO ClinVar Annotator: match by term: Familial isolated pituitary adenoma ClinVar PMID:25741868 NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,794 		JBrowse link
growth hormone secreting pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO ClinVar Annotator: match by term: Somatotroph adenoma ClinVar PMID:2200621 PMID:5320367 PMID:9482716 PMID:9536098 PMID:12213383 More... NCBI chr 2:5,042,883...5,048,885
Ensembl chr 2:5,041,990...5,048,781 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO protein:increased expression:pituitary gland: RGD PMID:18981426 RGD:8662821 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G GNAS GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:11254676 NCBI chr17:58,985,580...59,053,022
Ensembl chr17:58,998,981...59,053,021 		JBrowse link
G GPR101 G protein-coupled receptor 101 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr  X:112,109,592...112,111,333
Ensembl chr  X:112,108,889...112,113,652 		JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr14:15,718,261...15,773,534
Ensembl chr14:15,718,678...15,760,767 		JBrowse link
G MEN1 menin 1 ISO ClinVar Annotator: match by term: Somatotroph adenoma ClinVar PMID:30630164 NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952 		JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2042694 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
growth hormone secreting pituitary adenoma 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR101 G protein-coupled receptor 101 ISO ClinVar Annotator: match by term: Pituitary adenoma, growth hormone-secreting, 2 OMIM
ClinVar		 PMID:25470569 PMID:25741868 PMID:25806919 PMID:25806920 PMID:25806921 More... NCBI chr  X:112,109,592...112,111,333
Ensembl chr  X:112,108,889...112,113,652 		JBrowse link
pituitary adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVPR1B vasopressin receptor 1B ISO RGD PMID:28692683 RGD:14700668 NCBI chr 9:66,769,472...66,776,916
Ensembl chr 9:66,772,591...66,776,931 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO RGD PMID:12036912 RGD:619590 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO mRNA:altered expression:pituitary gland (human) RGD PMID:24169548 RGD:13792706 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
pituitary adenoma 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 1, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma predisposition OMIM
ClinVar		 PMID:2200621 PMID:16728643 PMID:17244780 PMID:17341560 PMID:17360484 More... NCBI chr 2:5,042,883...5,048,885
Ensembl chr 2:5,041,990...5,048,781 		JBrowse link
pituitary adenoma 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAS GNAS complex locus ISO ClinVar Annotator: match by term: Pituitary adenoma 3, multiple types OMIM
ClinVar		 PMID:1505964 PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 More... NCBI chr17:58,985,580...59,053,022
Ensembl chr17:58,998,981...59,053,021 		JBrowse link
pituitary adenoma 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 PMID:28492532 NCBI chr 2:5,042,883...5,048,885
Ensembl chr 2:5,041,990...5,048,781 		JBrowse link
G C14H10orf105 chromosome 14 C10orf105 homolog ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:11090341 PMID:11138009 PMID:12075507 PMID:12522556 PMID:15537665 More... NCBI chr14:74,630,827...74,639,180
Ensembl chr14:74,629,796...74,638,022 		JBrowse link
G CDH23 cadherin related 23 ISO ClinVar Annotator: match by term: PITUITARY ADENOMA 5, MULTIPLE TYPES | ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types OMIM
ClinVar		 PMID:2706105 PMID:9536098 PMID:11090341 PMID:11138009 PMID:11857743 More... NCBI chr14:74,267,547...74,734,623
Ensembl chr14:74,223,089...74,733,834 		JBrowse link
G MEN1 menin 1 ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 PMID:28492532 NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952 		JBrowse link
G VSIR V-set immunoregulatory receptor ISO ClinVar Annotator: match by term: Pituitary adenoma 5, multiple types ClinVar PMID:25741868 NCBI chr14:74,667,081...74,693,347
Ensembl chr14:74,666,624...74,693,281 		JBrowse link
prolactinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISO mRNA, protein:increased expression:pituitary gland
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12552124 PMID:16809920 RGD:629544 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637 		JBrowse link
G CEBPD CCAAT enhancer binding protein delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:21980073 NCBI chr 4:79,872,863...79,874,481
Ensembl chr 4:79,872,939...79,874,477 		JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase ISO mRNA:decreased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr14:15,718,261...15,773,534
Ensembl chr14:15,718,678...15,760,767 		JBrowse link
G LRP2 LDL receptor related protein 2 ISO ClinVar Annotator: match by term: Prolactinoma ClinVar PMID:17632512 PMID:25682901 PMID:25741868 PMID:28492532 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694 		JBrowse link
G MEN1 menin 1 ISO OMIM:600634 MouseDO NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:22635680 RGD:7240531 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G NOG noggin ISO mRNA, protein:decreased expression:pituitary RGD PMID:12552124 RGD:629544 NCBI chr12:32,891,321...32,892,206
Ensembl chr12:32,891,321...32,892,206 		JBrowse link
G NPY5R neuropeptide Y receptor Y5 ISO protein:increased expression:pars anterior RGD PMID:11026575 RGD:1625506 NCBI chr 8:52,173,906...52,183,336
Ensembl chr 8:52,174,434...52,183,341 		JBrowse link
G PRL prolactin sexual_dimorphism ISO DNA:mutation
protein:increased expression:blood serum (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:718334 PMID:1407345 PMID:3776530 PMID:9617019 PMID:12124824 More... RGD:1642576 RGD:401960111 RGD:401976454 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:pituitary gland RGD PMID:22580984 RGD:11667097 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15352
    disease of cellular proliferation 7271
      benign neoplasm 2122
        organ system benign neoplasm 1235
          endocrine organ benign neoplasm 147
            pituitary gland benign neoplasm 23
              pituitary adenoma + 23
              posterior pituitary gland neoplasm + 0
Path 2
Term Annotations click to browse term
  disease 15352
    disease of cellular proliferation 7271
      cancer 5332
        organ system cancer 5105
          nervous system cancer 931
            central nervous system cancer 759
              brain cancer 742
                supratentorial cancer 477
                  diencephalic neoplasm 37
                    hypothalamic neoplasm 37
                      Pituitary Neoplasms 35
                        pituitary gland benign neoplasm 23
                          pituitary adenoma + 23
                          posterior pituitary gland neoplasm + 0
paths to the root