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HTLV-1-associated myelopathy/tropical spastic paraparesis - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:HTLV-1-associated myelopathy/tropical spastic paraparesis
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Accession:DOID:321 term browser browse the term
Definition:A viral infectious disease that results in inflammation located in spinal cord, has_material_basis_in human T-cell leukemia virus type 1 (Deltaretrovirus priTlym1), which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms. (DO)
Synonyms:exact_synonym: Familial Spastic Paraparesis, Htlv 1 Associated;   HAM;   HAM/TSP;   HTLV-1-associated myelopathies;   HTLV-1-associated myelopathy;   HTLV-1-associated myelopathy/tropical spastic paraparesis;   HTLV-I associated myelopathies;   HTLV-I associated myelopathy;   HTLV-associated myelopathy;   Human T Lymphotropic Virus Type 1 Associated Myelopathy;   tropical spastic paralysis;   tropical spastic paraparesis;   tropical spastic paraplegia;   tropical spastic paraplegias
 xref: EFO:0007527;   ICD10CM:G04.1;   MESH:D015493;   MIM:159580;   MONDO:0008039;   NCI:C179058
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HTLV-1-associated myelopathy/tropical spastic paraparesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 ISO protein:increased processing:plasma RGD PMID:7561187 RGD:11040775 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO mRNA:decreased expression: T cell RGD PMID:20945034 RGD:38549361 NCBI chrNW_004955457:11,028,707...11,034,898
Ensembl chrNW_004955457:11,028,698...11,073,460 		JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 severity ISO protein:increased expression:plasma (human) RGD PMID:26800845 RGD:39939014 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Foxp3 forkhead box P3 disease_progression ISO mRNA:decreased expression: T cell RGD PMID:20945034 PMID:28101786 RGD:38456004 RGD:38549361 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO RGD PMID:11984596 RGD:10045967 NCBI chrNW_004955458:1,530,163...1,536,874 JBrowse link
G Il21 interleukin 21 ISO protein:decreased expression:blood serum (human) RGD PMID:28378248 RGD:127285561 NCBI chrNW_004955428:18,057,096...18,065,492
Ensembl chrNW_004955428:18,057,096...18,065,492 		JBrowse link
G Il27 interleukin 27 ISO associated with HTLV-I Infections;mRNA:decreased expression:blood (human) RGD PMID:24041428 RGD:126790519 NCBI chrNW_004955493:6,712,005...6,717,417
Ensembl chrNW_004955493:6,712,005...6,717,417 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO associated with Sjogren's Syndrome RGD PMID:10464559 RGD:8657078 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 susceptibility ISO DNA:SNP:5'utr: (rs3138045) (human) RGD PMID:22170554 RGD:39018559 NCBI chrNW_004955496:5,842,734...5,950,995
Ensembl chrNW_004955496:5,842,600...5,927,885 		JBrowse link
G Tnfrsf18 TNF receptor superfamily member 18 disease_progression ISO mRNA:decreased expression: T cell RGD PMID:20945034 PMID:28101786 RGD:38456004 RGD:38549361 NCBI chrNW_004955486:9,571,527...9,573,733
Ensembl chrNW_004955486:9,571,530...9,573,733 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 ISO OMIM:159580 MouseDO NCBI chrNW_004955429:23,011,627...23,198,188
Ensembl chrNW_004955429:23,010,790...23,198,250 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14338
    disease by infectious agent 1963
      Bacterial Infections and Mycoses 970
        Central Nervous System Infections 293
          myelitis 24
            HTLV-1-associated myelopathy/tropical spastic paraparesis 11
Path 2
Term Annotations click to browse term
  disease 14338
    disease of anatomical entity 14031
      nervous system disease 12352
        Neurologic Manifestations 9222
          Paresis 26
            Paraparesis 20
              Spastic Paraparesis 18
                HTLV-1-associated myelopathy/tropical spastic paraparesis 11
paths to the root