RGD Reference Report - Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. - Rat Genome Database

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Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.

Authors: Pinto, Mariana Tomazini  Malta, Tathiane Maistro  Rodrigues, Evandra Strazza  Pinheiro, Daniel Guariz  Panepucci, Rodrigo Alexandre  Malmegrim de Farias, Kelen Cristina Ribeiro  Sousa, Alessandra De Paula  Takayanagui, Osvaldo Massaiti  Tanaka, Yuetsu  Covas, Dimas Tadeu  Kashima, Simone 
Citation: Pinto MT, etal., AIDS Res Hum Retroviruses. 2014 Jun;30(6):610-22. doi: 10.1089/aid.2013.0109. Epub 2013 Oct 16.
RGD ID: 126790519
Pubmed: PMID:24041428   (View Abstract at PubMed)
PMCID: PMC4046198   (View Article at PubMed Central)
DOI: DOI:10.1089/aid.2013.0109   (Journal Full-text)

Human T cell leukemia virus type 1 (HTLV-1) preferentially infects CD4(+) T cells and these cells play a central role in HTLV-1 infection. In this study, we investigated the global gene expression profile of circulating CD4(+) T cells from the distinct clinical status of HTLV-1-infected individuals in regard to TAX expression levels. CD4(+) T cells were isolated from asymptomatic HTLV-1 carrier (HAC) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients in order to identify genes involved in HAM/TSP development using a microarray technique. Hierarchical clustering analysis showed that healthy control (CT) and HTLV-1-infected samples clustered separately. We also observed that the HAC and HAM/TSP groups clustered separately regardless of TAX expression. The gene expression profile of CD4(+) T cells was compared among the CT, HAC, and HAM/TSP groups. The paxillin (Pxn), chemokine (C-X-C motif ) receptor 4 (Cxcr4), interleukin 27 (IL27), and granzyme A (Gzma) genes were differentially expressed between the HAC and HAM/TSP groups, regardless of TAX expression. The perforin 1 (Prf1) and forkhead box P3 (Foxp3) genes were increased in the HAM/TSP group and presented a positive correlation to the expression of TAX and the proviral load (PVL). The frequency of CD4(+)FOXP3(+) regulatory T cells (Treg) was higher in HTLV-1-infected individuals. Foxp3 gene expression was positively correlated with cell lysis-related genes (Gzma, Gzmb, and Prf1). These findings suggest that CD4(+) T cell activity is distinct between the HAC and HAM/TSP groups.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27Humantropical spastic paraparesis  IEP associated with HTLV-I Infections and mRNA:decreased expression:blood (human)RGD 
Il27Rattropical spastic paraparesis  ISOIL27 (Homo sapiens)associated with HTLV-I Infections and mRNA:decreased expression:blood (human)RGD 
Il27Mousetropical spastic paraparesis  ISOIL27 (Homo sapiens)associated with HTLV-I Infections and mRNA:decreased expression:blood (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information