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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:endometrial adenocarcinoma
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Accession:DOID:2870 term browser browse the term
Definition:An endometrial carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:exact_synonym: EEC;   Type I endometrial carcinoma;   adenocarcinoma of endometrium;   adenocarcinoma of the endometrium;   adenocarcinoma of uterus;   endometrial adenoacanthoma;   endometrial endometrioid adenocarcinoma;   endometrial endometrioid carcinoma;   endometrioid adenoma or carcinoma;   endometrioid carcinoma of endometrium
 narrow_synonym: ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA, VARIANT WITH SQUAMOUS DIFFERENTIATION;   endometrial endometrioid adenocarcinoma with squamous differentiation
 broad_synonym: endometrioid adenomas and carcinomas;   endometrioid endometrial cancer
 xref: EFO:0005232;   EFO:1000233;   EFO:1001514;   EFO:1001953;   NCI:C3769;   NCI:C6287;   NCI:C6290;   NCI:C63961;   NCI:C7359
For additional species annotation, visit the Alliance of Genome Resources.

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endometrial adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 ISO protein:increased expression:endometrium epithelium RGD PMID:17295646 RGD:2293852 NCBI chrNW_004624763:22,645,807...22,818,592
Ensembl chrNW_004624763:22,646,231...22,718,294 		JBrowse link
G Angpt2 angiopoietin 2 ISO protein:increased expression:endometrium epithelium RGD PMID:17295646 RGD:2293852 NCBI chrNW_004624861:4,457,519...4,510,035
Ensembl chrNW_004624861:4,457,158...4,509,623 		JBrowse link
G Arid1a AT-rich interaction domain 1A treatment ISO human cell in mouse model RGD PMID:21900401 RGD:126725086 NCBI chrNW_004624764:10,672,673...10,759,634
Ensembl chrNW_004624764:10,672,735...10,759,634 		JBrowse link
G Axin2 axin 2 ISO RGD PMID:11940574 RGD:13432156 NCBI chrNW_004624870:2,803,743...2,832,489
Ensembl chrNW_004624870:2,800,873...2,832,626 		JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein like disease_progression ISO RGD PMID:28654152 RGD:14394612 NCBI chrNW_004624766:22,240,960...22,245,040
Ensembl chrNW_004624766:22,240,972...22,245,040 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) ISO RGD PMID:11506079 RGD:2326173 NCBI chrNW_004624807:4,252,676...4,274,828 JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 ISO protein:increased expression:endometrium RGD PMID:16112719 RGD:2289850 NCBI chrNW_004624763:8,621,666...8,649,109
Ensembl chrNW_004624763:8,621,638...8,650,016 		JBrowse link
G Foxo3 forkhead box O3 severity ISO associated with Obesity;protein:decreased expression:endometrium (human) RGD PMID:26045339 RGD:11530998 NCBI chrNW_004624780:13,621,733...13,740,399
Ensembl chrNW_004624780:13,622,948...13,740,374 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO mRNA:decreased expression:endometrium (rat) RGD PMID:19426485 RGD:2312621 NCBI chrNW_004624733:40,957,895...40,963,469
Ensembl chrNW_004624733:40,957,999...40,962,993 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO DNA:deletions (rat) RGD PMID:19075038 RGD:5128782 NCBI chrNW_004624733:39,596,565...39,603,428
Ensembl chrNW_004624733:39,596,501...39,603,526 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit no_association ISO protein, mRNA::endometrial epithelium and stroma:no correlation between expression and type of tissue or cancer stage or grade RGD PMID:10684716 RGD:2290482 NCBI chrNW_004624862:1,537,886...1,540,633
Ensembl chrNW_004624862:1,538,455...1,539,426 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO DNA:point mutation:CDS:p.G12D, p.G12S, p.Q61H (rat) RGD PMID:10775052 RGD:1600499 NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO human tumor in a mouse model
protein:decreased phosphorylation:endometrium (human)		 RGD PMID:14760076 PMID:23402905 RGD:13703125 RGD:13703137 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO protein:decreased phosphorylation:endometrium (human)
human tumor in a mouse model		 RGD PMID:14760076 PMID:23402905 RGD:13703125 RGD:13703137 NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113 		JBrowse link
G Pdcd10 programmed cell death 10 disease_progression ISO protein:increased expression:endometrium (human) RGD PMID:32186778 RGD:401827111 NCBI chrNW_004624730:45,653,470...45,698,461
Ensembl chrNW_004624730:45,654,022...45,678,745 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO DNA:mutations:multiple (human) RGD PMID:21478295 RGD:13441595 NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610 		JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO RGD PMID:32843721 RGD:127285600 NCBI chrNW_004624791:13,975,235...14,056,900 JBrowse link
G Ptges prostaglandin E synthase ISO protein:increased expression:endometrium RGD PMID:11592775 RGD:2300089 NCBI chrNW_004624760:5,643,549...5,653,747
Ensembl chrNW_004624760:5,643,501...5,654,475 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 ISO DNA:amplification (rat) RGD PMID:15942940 RGD:2324953 NCBI chrNW_004624865:4,984,353...4,990,187
Ensembl chrNW_004624865:4,985,620...4,990,120 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 ISO mRNA:decreased expression:endometrium RGD PMID:15745937 RGD:1579943 NCBI chrNW_004624742:5,871,155...6,080,773 JBrowse link
G Tp53 tumor protein p53 disease_progression ISO DNA:missense mutations
protein:increased expression:endometrium		 RGD PMID:1540970 RGD:2290541 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
G Tsg101 tumor susceptibility 101 ISO mRNA:alternative forms RGD PMID:10027311 RGD:2291854 NCBI chrNW_004624766:9,932,190...9,977,725
Ensembl chrNW_004624766:9,934,228...9,977,697 		JBrowse link
endometrial serous adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO ClinVar Annotator: match by term: Uterine corpus serous adenocarcinoma ClinVar NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
G Brca2 BRCA2 DNA repair associated susceptibility ISO DNA:deletion: :6174delT RGD PMID:16650962 RGD:2289045 NCBI chrNW_004624776:5,497,552...5,573,465
Ensembl chrNW_004624776:5,497,779...5,550,993 		JBrowse link
G Msh6 mutS homolog 6 ISO ClinVar Annotator: match by term: Papillary carcinoma of the corpus uteri ClinVar PMID:18269114 PMID:21642682 PMID:24362816 PMID:25741868 PMID:28492532 More... NCBI chrNW_004624738:29,083,696...29,108,792
Ensembl chrNW_004624738:29,083,692...29,108,792 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14208
    disease of cellular proliferation 6872
      cancer 5073
        cell type cancer 3382
          carcinoma 2863
            adenocarcinoma 1482
              endometrial adenocarcinoma 25
                endometrial clear cell adenocarcinoma 0
                endometrial endometrioid adenocarcinoma, secretory variant 0
                endometrial mixed adenocarcinoma 0
                endometrial mucinous adenocarcinoma 0
                endometrial serous adenocarcinoma 3
                mucin-rich endometrial endometrioid adenocarcinoma 0
                oxyphilic endometrial endometrioid adenocarcinoma 0
                sarcomatoid uterine corpus endometrioid adenocarcinoma 0
                villoglandular endometrial endometrioid adenocarcinoma 0
Path 2
Term Annotations click to browse term
  disease 14208
    disease of anatomical entity 13924
      Urogenital Diseases 4515
        Female Urogenital Diseases and Pregnancy Complications 2375
          Female Urogenital Diseases 1976
            female reproductive system disease 1973
              uterine disease 461
                Uterine Neoplasms 416
                  uterine cancer 287
                    endometrial cancer 181
                      endometrial carcinoma 126
                        Endometrioid Carcinomas 62
                          endometrial adenocarcinoma 25
                            endometrial clear cell adenocarcinoma 0
                            endometrial endometrioid adenocarcinoma, secretory variant 0
                            endometrial mixed adenocarcinoma 0
                            endometrial mucinous adenocarcinoma 0
                            endometrial serous adenocarcinoma 3
                            mucin-rich endometrial endometrioid adenocarcinoma 0
                            oxyphilic endometrial endometrioid adenocarcinoma 0
                            sarcomatoid uterine corpus endometrioid adenocarcinoma 0
                            villoglandular endometrial endometrioid adenocarcinoma 0
paths to the root