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pancreatic endocrine carcinoma - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pancreatic endocrine carcinoma
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Accession:DOID:1798 term browser browse the term
Definition:An islet cell tumor that has_material_basis_in epithelial cells. (DO)
Synonyms:exact_synonym: Islet Cell Carcinoma;   Islet Cell Tumor, Malignant;   carcinoma of endocrine pancreas;   islet cell carcinomas;   malignant neoplasm of islets of Langerhans;   pancreatic neuroendocrine carcinoma
 narrow_synonym: METASTATIC PANCREATIC NEUROENDOCRINE TUMORS;   neuroendocrine tumor of pancreas
 primary_id: MESH:D018273
 xref: EFO:0007416;   EFO:0009140;   GARD:13034;   ICD9CM:157.4;   NCI:C3770
For additional species annotation, visit the Alliance of Genome Resources.

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pancreatic endocrine carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 breast cancer 2, early onset ISO ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas ClinVar PMID:15145354 PMID:22762150 PMID:25741868 PMID:29446198 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794 		JBrowse link
G Cux1 cut-like homeobox 1 exacerbates ISO protein:increased expression:pancreas (human) RGD PMID:32707646 RGD:153297777 NCBI chr 5:136,276,989...136,596,429
Ensembl chr 5:136,276,989...136,596,344 		JBrowse link
G Daxx Fas death domain-associated protein disease_progression ISO DNA:frameshift, frameshift mutations, nonsense mutation, missense mutations:CDS:multiple (human) RGD PMID:29212165 RGD:152025205 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO DNA:hypermethylation:promoter (human) RGD PMID:14501508 RGD:2317661 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Palb2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Neuroendocrine tumor of pancreas ClinVar PMID:17200668 PMID:17200671 PMID:17200672 PMID:24136930 PMID:25099575 More... NCBI chr 7:121,706,485...121,732,203
Ensembl chr 7:121,706,485...121,732,208 		JBrowse link
G Pgf placental growth factor disease_progression
treatment		 ISO
IMP		 protein:increased expression:serum (human)
human cells in a mouse model		 RGD PMID:23463017 PMID:26861455 RGD:14349029, RGD:14349030 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
duodenal gastrinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Men1 multiple endocrine neoplasia 1 ISO associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: : RGD PMID:17135306 RGD:2317341 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
gastrinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin-like growth factor I receptor ISO mRNA and protein: increased expression::poor prognosis for high expression RGD PMID:15867218 RGD:7242847 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO DNA:mutations: :
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17961653 PMID:15944766 RGD:2317354 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Met met proto-oncogene severity ISO associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human) RGD PMID:12114431 RGD:2317605 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO DNA:hypomethylation:promoter (human) RGD PMID:17278096 RGD:2317340 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 ISO mRNA:decreased expression:pancreatic islet RGD PMID:8421107 PMID:12114701 RGD:2324977, RGD:2324976 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
Glucagonoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btc betacellulin, epidermal growth factor family member ISO protein:increased expression:pancreas RGD PMID:10724350 RGD:2326087 NCBI chr 5:91,505,120...91,550,853
Ensembl chr 5:91,505,120...91,550,853 		JBrowse link
G Men1 multiple endocrine neoplasia 1 IMP
ISO		 DNA:deletion:exon
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17961653 PMID:20138042 RGD:2317288 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 ISO mRNA:decreased expression:pancreatic islet RGD PMID:12114701 PMID:8421107 RGD:2324976, RGD:2324977 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
G Sstr4 somatostatin receptor 4 ISO RGD PMID:8132773 RGD:2324994 NCBI chr 2:148,237,297...148,238,684
Ensembl chr 2:148,237,264...148,238,687 		JBrowse link
vipoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifna1 interferon alpha 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17961653 NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961653 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Sst somatostatin ISO CTD Direct Evidence: therapeutic CTD PMID:2868874 NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16268
    disease of anatomical entity 15860
      endocrine system disease 6555
        endocrine gland cancer 2608
          pancreatic cancer 422
            pancreatic endocrine carcinoma 14
              Glucagonoma 4
              gastrinoma + 5
              somatostatinoma 0
              vipoma + 3
Path 2
Term Annotations click to browse term
  disease 16268
    disease of anatomical entity 15860
      nervous system disease 13798
        Nervous System Neoplasms 1558
          nervous system cancer 897
            neuroectodermal tumor 476
              neuroendocrine tumor 219
                islet cell tumor 30
                  pancreatic endocrine carcinoma 14
                    Glucagonoma 4
                    gastrinoma + 5
                    somatostatinoma 0
                    vipoma + 3
paths to the root