Men1 (multiple endocrine neoplasia 1) - Rat Genome Database

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Gene: Men1 (multiple endocrine neoplasia 1) Mus musculus
Analyze
Symbol: Men1
Name: multiple endocrine neoplasia 1
RGD ID: 736444
MGI Page MGI
Description: Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in histone H3-K4 methylation. Acts upstream of or within several processes, including negative regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of osteoblast differentiation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW045611; me; menin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,385,009 - 6,390,924 (+)NCBIGRCm39mm39
GRCm39 Ensembl196,385,009 - 6,390,921 (+)Ensembl
GRCm38196,334,979 - 6,340,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,334,979 - 6,340,891 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,334,979 - 6,340,894 (+)NCBIGRCm37mm9NCBIm37
MGSCv36196,335,039 - 6,340,889 (+)NCBImm8
Celera196,207,959 - 6,213,874 (+)NCBICelera
Cytogenetic Map19ANCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (ISO)
cell division  (IMP)
cell population proliferation  (IDA,IGI,IMP)
cellular response to DNA damage stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IGI,IMP)
decidualization  (ISO)
embryonic skeletal system morphogenesis  (IMP)
fibroblast apoptotic process  (IDA,IGI)
fibroblast proliferation  (IMP)
hemopoiesis  (IMP)
histone H3-K4 methylation  (IMP,ISO)
histone methylation  (IDA,IMP)
leukocyte homeostasis  (IMP)
MAPK cascade  (ISO)
maternal process involved in female pregnancy  (IDA)
mitotic cell cycle  (ISO)
negative regulation of cell cycle  (IBA,ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell population proliferation  (IBA,IDA,IMP,ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of fibroblast proliferation  (IMP)
negative regulation of JNK cascade  (ISO)
negative regulation of organ growth  (IDA)
negative regulation of osteoblast differentiation  (IDA,IGI,ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of stem cell proliferation  (IGI,IMP)
negative regulation of telomerase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of type B pancreatic cell proliferation  (IDA,IMP)
organ growth  (IDA)
ossification  (IMP)
osteoblast development  (IGI,ISO)
osteoblast fate commitment  (IGI)
positive regulation of cell division  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of fibroblast apoptotic process  (IDA,IGI)
positive regulation of gene expression  (IDA,IMP)
positive regulation of histone methylation  (IMP)
positive regulation of osteoblast differentiation  (IGI)
positive regulation of protein binding  (ISO)
positive regulation of stem cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of activin receptor signaling pathway  (ISO)
regulation of G1/S transition of mitotic cell cycle  (IMP)
regulation of gene expression  (IDA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of type B pancreatic cell proliferation  (ISO)
response to gamma radiation  (ISO)
response to transforming growth factor beta  (ISO)
response to UV  (ISO)
roof of mouth development  (IMP)
stem cell differentiation  (IMP)
stem cell proliferation  (IGI,IMP)
type B pancreatic cell differentiation  (ISO)
type B pancreatic cell proliferation  (IDA,IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal pituitary gland morphology  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased embryo size  (IAGP)
decreased tumor latency  (IAGP)
delayed hepatic development  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged ovary  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged parathyroid gland  (IAGP)
enlarged pituitary gland  (IAGP)
enlarged testis  (IAGP)
exencephaly  (IAGP)
hemorrhage  (IAGP)
hypoglycemia  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adrenal cortical tumor incidence  (IAGP)
increased adrenal gland adenoma incidence  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased adrenocortical adenoma incidence  (IAGP)
increased carcinoma incidence  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating insulin level  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased gland tumor incidence  (IAGP)
increased glucagonoma incidence  (IAGP)
increased gonad tumor incidence  (IAGP)
increased insulinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased Leydig cell number  (IAGP)
increased Leydig cell tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased metastatic potential  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas adenoma incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic islet cell adenoma incidence  (IAGP)
increased pancreatic islet cell carcinoma incidence  (IAGP)
increased parathyroid adenoma incidence  (IAGP)
increased parathyroid gland tumor incidence  (IAGP)
increased pheochromocytoma incidence  (IAGP)
increased pituitary adenohypophysis tumor incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased pituitary gland tumor incidence  (IAGP)
increased pituitary melanotroph tumor incidence  (IAGP)
increased prolactinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased testis tumor incidence  (IAGP)
increased thyroid adenoma incidence  (IAGP)
increased thyroid C-cell carcinoma incidence  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroid tumor incidence  (IAGP)
increased tumor incidence  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
pancreas cyst  (IAGP)
pancreas inflammation  (IAGP)
pancreas necrosis  (IAGP)
pancreatic islet hyperplasia  (IAGP)
parathyroid gland hyperplasia  (IAGP)
premature death  (IAGP)
thin interventricular septum  (IAGP)
thin ventricular wall  (IAGP)
thyroid gland cyst  (IAGP)
thyroid gland hyperplasia  (IAGP)
trabecula carnea hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions. Anlauf M, etal., Gut. 2007 May;56(5):637-44. Epub 2006 Nov 29.
2. Analysis of molecular pathways in sporadic neuroendocrine tumors of the gastro-entero-pancreatic system. Arnold CN, etal., Int J Cancer. 2007 May 15;120(10):2157-64.
3. MEN1 gene mutations in Hungarian patients with multiple endocrine neoplasia type 1. Balogh K, etal., Clin Endocrinol (Oxf). 2007 Nov;67(5):727-34.
4. Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Bertolino P, etal., Cancer Res. 2003 Aug 15;63(16):4836-41.
5. Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma. Cavallari I, etal., Genes Chromosomes Cancer. 2009 May;48(5):383-96.
6. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Crabtree JS, etal., Mol Cell Biol. 2003 Sep;23(17):6075-85.
7. Recessive transmission of a multiple endocrine neoplasia syndrome in the rat. Fritz A, etal., Cancer Res 2002 Jun 1;62(11):3048-51.
8. Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. Harding B, etal., Endocr Relat Cancer. 2009 Dec;16(4):1313-27. Epub 2009 Jul 20.
9. Characteristics of the Danish families with multiple endocrine neoplasia type 1. Jager AC, etal., Mol Cell Endocrinol. 2006 Apr 25;249(1-2):123-32. Epub 2006 Mar 23.
10. MEN1 mutation analysis in Chinese patients with multiple endocrine neoplasia type 1. Jiang XH, etal., Endocr Relat Cancer. 2007 Dec;14(4):1073-9.
11. Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene. Karges W, etal., Biochim Biophys Acta 1999 Sep 3;1446(3):286-94.
12. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Karnik SK, etal., Science. 2007 Nov 2;318(5851):806-9.
13. Multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas in Japan. Kawamura J, etal., Oncol Rep. 2005 Jul;14(1):47-52.
14. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Lemmens I, etal., Hum Mol Genet. 1997 Jul;6(7):1177-83.
15. alpha Cell-Specific Men1 Ablation Triggers the Transdifferentiation of Glucagon-Expressing Cells and Insulinoma Development. Lu J, etal., Gastroenterology. 2010 Feb 2.
16. Structure and distribution of rat menin mRNA. Maruyama K, etal., Mol Cell Endocrinol 1999 Oct 25;156(1-2):25-33.
17. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Analysis of gross deletions in the MEN1 gene in patients with multiple endocrine neoplasia type 1. Owens M, etal., Clin Endocrinol (Oxf). 2008 Mar;68(3):350-4. Epub 2007 Sep 14.
22. Two novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1. Ozturk M, etal., J Endocrinol Invest. 2006 Jun;29(6):523-7.
23. Novel germline mutations of the MEN1 gene in Greek families with multiple endocrine neoplasia type 1. Peppa M, etal., Clin Endocrinol (Oxf). 2009 Jan;70(1):75-81. Epub 2008 Jun 12.
24. Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells. Ratineau C, etal., J Biol Chem 2004 Jun 4;279(23):24477-84. Epub 2004 Mar 30.
25. Mouse MP Annotation Import Pipeline RGD automated import pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Multiple endocrine neoplasia type 1: new clinical and basic findings. Schussheim DH, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):173-8.
29. Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1. Shen HC, etal., Cancer Res. 2009 Mar 1;69(5):1858-66. Epub 2009 Feb 10.
30. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
31. Clinical testing for mutations in the MEN1 gene in Sweden: a report on 200 unrelated cases. Tham E, etal., J Clin Endocrinol Metab. 2007 Sep;92(9):3389-95. Epub 2007 Jul 10.
32. Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients. Trouillas J, etal., Am J Surg Pathol. 2008 Apr;32(4):534-43.
33. Microsatellite instability and loss of heterozygosity at the MEN1 locus in lung carcinoid tumors: a novel approach using real-time PCR with melting curve analysis in histopathologic material. Vageli D, etal., Oncol Rep. 2006 Mar;15(3):557-64.
34. Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation. Vierimaa O, etal., Eur J Endocrinol. 2007 Sep;157(3):285-94.
35. Increased menin expression in sporadic pituitary adenomas. Wrocklage C, etal., Clin Endocrinol (Oxf). 2002 May;56(5):589-94.
36. Early changes of beta-Catenins and Menins in spinal cord dorsal horn after peripheral nerve injury. Zhang X, etal., Cell Mol Neurobiol. 2010 Aug;30(6):885-90. doi: 10.1007/s10571-010-9517-9. Epub 2010 Apr 6.
Additional References at PubMed
PMID:8889548   PMID:9824159   PMID:9893060   PMID:10341092   PMID:10349636   PMID:10529376   PMID:10818209   PMID:10922068   PMID:11042159   PMID:11064160   PMID:11076861   PMID:11158604  
PMID:11217851   PMID:11500056   PMID:11536432   PMID:11544199   PMID:11579199   PMID:11712086   PMID:11857805   PMID:12203793   PMID:12466851   PMID:12477932   PMID:12649288   PMID:12755956  
PMID:12782272   PMID:12819299   PMID:14633735   PMID:14688275   PMID:14992727   PMID:15044367   PMID:15060136   PMID:15150273   PMID:15254225   PMID:15331604   PMID:15563473   PMID:15640349  
PMID:15672591   PMID:15782199   PMID:16001329   PMID:16141072   PMID:16141073   PMID:16195383   PMID:16415155   PMID:16435884   PMID:16528608   PMID:16618927   PMID:16625857   PMID:16740708  
PMID:17044021   PMID:17125736   PMID:17145768   PMID:17158767   PMID:17173065   PMID:17183676   PMID:17184987   PMID:17409423   PMID:17500065   PMID:17707229   PMID:17766243   PMID:17893233  
PMID:17927973   PMID:17951404   PMID:18310289   PMID:18323693   PMID:18772165   PMID:18799693   PMID:19058182   PMID:19074834   PMID:19106332   PMID:19228930   PMID:19393316   PMID:19407509  
PMID:19464283   PMID:19587266   PMID:19596783   PMID:19608464   PMID:19651895   PMID:19703992   PMID:20059953   PMID:20399832   PMID:20404349   PMID:20555035   PMID:20663219   PMID:20956546  
PMID:21059956   PMID:21127195   PMID:21129151   PMID:21239436   PMID:21264795   PMID:21267068   PMID:21378168   PMID:21468568   PMID:21670200   PMID:21677750   PMID:21740816   PMID:21788502  
PMID:21833538   PMID:21873635   PMID:22001208   PMID:22037578   PMID:22120711   PMID:22193451   PMID:22327296   PMID:22492302   PMID:22666422   PMID:22708734   PMID:22766853   PMID:22858595  
PMID:22915754   PMID:23024266   PMID:23027861   PMID:23180448   PMID:23349306   PMID:23580576   PMID:23583653   PMID:23744037   PMID:23867312   PMID:23892456   PMID:23908472   PMID:23928057  
PMID:24101467   PMID:24157940   PMID:24457600   PMID:24531709   PMID:24563463   PMID:24694524   PMID:24824656   PMID:24905306   PMID:24994111   PMID:25088994   PMID:25133424   PMID:25136117  
PMID:25343275   PMID:25517963   PMID:25537453   PMID:25565142   PMID:25591470   PMID:25866973   PMID:25885930   PMID:25962847   PMID:26169832   PMID:26261055   PMID:26324324   PMID:26495792  
PMID:26534984   PMID:26678830   PMID:26709830   PMID:26711255   PMID:26860771   PMID:26884209   PMID:26927674   PMID:26990064   PMID:27151693   PMID:27432891   PMID:27798149   PMID:27801610  
PMID:27872097   PMID:28106886   PMID:28188614   PMID:28215965   PMID:28270438   PMID:28496137   PMID:28602220   PMID:28609655   PMID:28659357   PMID:28859856   PMID:28991228   PMID:29309627  
PMID:29335487   PMID:29413895   PMID:29481652   PMID:30021166   PMID:30099020   PMID:30120246   PMID:30220511   PMID:30315824   PMID:31160716   PMID:32081882   PMID:32156729   PMID:32733644  
PMID:32847108   PMID:32968282   PMID:33323967   PMID:33542482   PMID:33821572   PMID:34065662   PMID:34285285   PMID:34582559   PMID:34878630   PMID:34943798   PMID:35182330   PMID:35194044  
PMID:35628193  


Genomics

Comparative Map Data
Men1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,385,009 - 6,390,924 (+)NCBIGRCm39mm39
GRCm39 Ensembl196,385,009 - 6,390,921 (+)Ensembl
GRCm38196,334,979 - 6,340,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,334,979 - 6,340,891 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,334,979 - 6,340,894 (+)NCBIGRCm37mm9NCBIm37
MGSCv36196,335,039 - 6,340,889 (+)NCBImm8
Celera196,207,959 - 6,213,874 (+)NCBICelera
Cytogenetic Map19ANCBI
MEN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,803,516 - 64,811,294 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1164,803,510 - 64,811,294 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,570,988 - 64,578,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,327,564 - 64,335,342 (-)NCBINCBI36hg18NCBI36
Build 341164,327,571 - 64,335,342NCBI
Celera1161,897,163 - 61,904,940 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,898,267 - 60,932,150 (-)NCBIHuRef
CHM1_11164,454,762 - 64,462,538 (-)NCBICHM1_1
T2T-CHM13v2.01164,796,826 - 64,804,601 (-)NCBI
Men1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21203,638,905 - 203,644,871 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1203,639,000 - 203,644,871 (+)Ensembl
Rnor_6.01221,704,394 - 221,710,343 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,704,493 - 221,710,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,692,520 - 228,698,433 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,114,987 - 209,120,837 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11209,273,349 - 209,279,258 (+)NCBI
Celera1201,172,444 - 201,178,294 (+)NCBICelera
Cytogenetic Map1q43NCBI
Men1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,356,491 - 20,363,575 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,356,491 - 20,363,374 (+)NCBIChiLan1.0ChiLan1.0
MEN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11163,499,954 - 63,507,164 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,499,962 - 63,507,164 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01160,159,009 - 60,166,222 (-)NCBIMhudiblu_PPA_v0panPan3
MEN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,346,747 - 52,352,884 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,346,933 - 52,353,340 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,954,682 - 50,959,679 (+)NCBI
ROS_Cfam_1.01853,387,971 - 53,394,108 (+)NCBI
ROS_Cfam_1.0 Ensembl1853,388,138 - 53,394,414 (+)Ensembl
UMICH_Zoey_3.11852,483,508 - 52,488,505 (+)NCBI
UNSW_CanFamBas_1.01852,069,239 - 52,074,237 (+)NCBI
UU_Cfam_GSD_1.01852,853,531 - 52,858,531 (+)NCBI
Men1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,062,038 - 8,068,200 (+)NCBI
SpeTri2.0NW_0049365994,504,489 - 4,510,085 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,358,218 - 7,364,952 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,358,130 - 7,364,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,490,697 - 6,497,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,423,885 - 9,431,123 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl19,423,917 - 9,431,104 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038106,810,667 - 106,817,860 (+)NCBIVero_WHO_p1.0
Men1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,579,103 - 21,585,373 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476721,579,084 - 21,585,380 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AW045611  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38196,340,500 - 6,340,608UniSTSGRCm38
MGSCv37196,340,500 - 6,340,608UniSTSGRCm37
Celera196,213,480 - 6,213,588UniSTS
Cytogenetic Map19AUniSTS
Whitehead/MRC_RH1942.49UniSTS
Men1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38196,333,475 - 6,333,741UniSTSGRCm38
MGSCv37196,333,475 - 6,333,741UniSTSGRCm37
Celera196,206,455 - 6,206,721UniSTS
Cytogenetic Map19AUniSTS
cM Map19 UniSTS
REN56546  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38196,335,590 - 6,335,841UniSTSGRCm38
MGSCv37196,335,590 - 6,335,841UniSTSGRCm37
Celera196,208,570 - 6,208,821UniSTS
Cytogenetic Map19AUniSTS
Men1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38196,335,825 - 6,337,514UniSTSGRCm38
MGSCv37196,335,825 - 6,337,514UniSTSGRCm37
Celera196,208,805 - 6,210,494UniSTS
Cytogenetic Map19AUniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
25394536Skmw86_mskeletal muscle weight 86, TA (mouse)1950648178957825Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3555
Count of miRNA genes:544
Interacting mature miRNAs:666
Transcripts:ENSMUST00000056391, ENSMUST00000078137, ENSMUST00000079327, ENSMUST00000113500, ENSMUST00000113501, ENSMUST00000113502, ENSMUST00000113503, ENSMUST00000113504, ENSMUST00000156154, ENSMUST00000166909, ENSMUST00000170132, ENSMUST00000170292
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001168488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001168489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001168490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB023401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF024513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF093756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF130368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY319905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY619391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF170561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX568988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000056391   ⟹   ENSMUSP00000058149
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,069 - 6,390,919 (+)Ensembl
GRCm38.p6 Ensembl196,335,039 - 6,340,889 (+)Ensembl
RefSeq Acc Id: ENSMUST00000078137   ⟹   ENSMUSP00000077272
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,141 - 6,390,919 (+)Ensembl
GRCm38.p6 Ensembl196,335,111 - 6,340,889 (+)Ensembl
RefSeq Acc Id: ENSMUST00000079327   ⟹   ENSMUSP00000078306
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,043 - 6,390,919 (+)Ensembl
GRCm38.p6 Ensembl196,335,013 - 6,340,889 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113500   ⟹   ENSMUSP00000109128
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,077 - 6,390,813 (+)Ensembl
GRCm38.p6 Ensembl196,335,047 - 6,340,783 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113501   ⟹   ENSMUSP00000109129
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,069 - 6,390,919 (+)Ensembl
GRCm38.p6 Ensembl196,335,039 - 6,340,889 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113502   ⟹   ENSMUSP00000109130
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,009 - 6,390,910 (+)Ensembl
GRCm38.p6 Ensembl196,334,979 - 6,340,880 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113503   ⟹   ENSMUSP00000109131
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,491 - 6,390,202 (+)Ensembl
GRCm38.p6 Ensembl196,335,461 - 6,340,172 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113504   ⟹   ENSMUSP00000109132
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,009 - 6,390,921 (+)Ensembl
GRCm38.p6 Ensembl196,334,979 - 6,340,891 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156154
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,076 - 6,390,921 (+)Ensembl
GRCm38.p6 Ensembl196,335,046 - 6,340,891 (+)Ensembl
RefSeq Acc Id: ENSMUST00000166909   ⟹   ENSMUSP00000133085
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,094 - 6,390,493 (+)Ensembl
GRCm38.p6 Ensembl196,335,064 - 6,340,463 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170132   ⟹   ENSMUSP00000126655
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,386,940 - 6,388,438 (+)Ensembl
GRCm38.p6 Ensembl196,336,910 - 6,338,408 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170292   ⟹   ENSMUSP00000128607
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,389,877 - 6,390,842 (+)Ensembl
GRCm38.p6 Ensembl196,339,847 - 6,340,812 (+)Ensembl
RefSeq Acc Id: ENSMUST00000237909   ⟹   ENSMUSP00000158389
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,385,070 - 6,385,756 (+)Ensembl
GRCm38.p6 Ensembl196,335,040 - 6,335,726 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238038
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,388,945 - 6,389,859 (+)Ensembl
GRCm38.p6 Ensembl196,338,915 - 6,339,829 (+)Ensembl
RefSeq Acc Id: NM_001168488   ⟹   NP_001161960
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,385,009 - 6,390,924 (+)NCBI
GRCm38196,334,979 - 6,340,894 (+)ENTREZGENE
MGSCv37196,334,979 - 6,340,894 (+)RGD
Celera196,207,959 - 6,213,874 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001168489   ⟹   NP_001161961
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,385,043 - 6,390,924 (+)NCBI
GRCm38196,335,013 - 6,340,894 (+)NCBI
MGSCv37196,334,979 - 6,340,894 (+)RGD
Celera196,207,959 - 6,213,874 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001168490   ⟹   NP_001161962
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,385,069 - 6,390,924 (+)NCBI
GRCm38196,335,039 - 6,340,894 (+)NCBI
MGSCv37196,334,979 - 6,340,894 (+)RGD
Celera196,207,959 - 6,213,874 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008583   ⟹   NP_032609
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,385,069 - 6,390,924 (+)NCBI
GRCm38196,335,039 - 6,340,894 (+)NCBI
MGSCv37196,334,979 - 6,340,894 (+)RGD
Celera196,207,959 - 6,213,874 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032609   ⟸   NM_008583
- Peptide Label: isoform b
- UniProtKB: O88559 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001161960   ⟸   NM_001168488
- Peptide Label: isoform a
- UniProtKB: O88559 (UniProtKB/Swiss-Prot),   A0A0R4J1I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001161961   ⟸   NM_001168489
- Peptide Label: isoform b
- UniProtKB: O88559 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001161962   ⟸   NM_001168490
- Peptide Label: isoform c
- UniProtKB: O88559 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128607   ⟸   ENSMUST00000170292
RefSeq Acc Id: ENSMUSP00000126655   ⟸   ENSMUST00000170132
RefSeq Acc Id: ENSMUSP00000158389   ⟸   ENSMUST00000237909
RefSeq Acc Id: ENSMUSP00000078306   ⟸   ENSMUST00000079327
RefSeq Acc Id: ENSMUSP00000109128   ⟸   ENSMUST00000113500
RefSeq Acc Id: ENSMUSP00000109130   ⟸   ENSMUST00000113502
RefSeq Acc Id: ENSMUSP00000109129   ⟸   ENSMUST00000113501
RefSeq Acc Id: ENSMUSP00000109132   ⟸   ENSMUST00000113504
RefSeq Acc Id: ENSMUSP00000109131   ⟸   ENSMUST00000113503
RefSeq Acc Id: ENSMUSP00000133085   ⟸   ENSMUST00000166909
RefSeq Acc Id: ENSMUSP00000058149   ⟸   ENSMUST00000056391
RefSeq Acc Id: ENSMUSP00000077272   ⟸   ENSMUST00000078137

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88559-F1-model_v2 AlphaFold O88559 1-611 view protein structure

Promoters
RGD ID:6830193
Promoter ID:MM_KWN:26177
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000113500,   ENSMUST00000113501,   ENSMUST00000113503,   NM_001168488,   NM_001168489,   NM_001168490,   NM_008583,   NM_008583_MEN1,   OTTMUST00000044791,   OTTMUST00000083389
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36196,334,696 - 6,335,627 (+)MPROMDB
RGD ID:13678660
Promoter ID:EPDNEW_M23479
Type:initiation region
Name:Men1_1
Description:Mus musculus multiple endocrine neoplasia 1 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38196,335,038 - 6,335,098EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1316736 AgrOrtholog
Ensembl Genes ENSMUSG00000024947 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000058149 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000077272 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000078306 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109128 UniProtKB/Swiss-Prot
  ENSMUSP00000109129.2 UniProtKB/TrEMBL
  ENSMUSP00000109130 ENTREZGENE
  ENSMUSP00000109130.4 UniProtKB/TrEMBL
  ENSMUSP00000109131.4 UniProtKB/TrEMBL
  ENSMUSP00000109132 UniProtKB/Swiss-Prot
  ENSMUSP00000126655.2 UniProtKB/TrEMBL
  ENSMUSP00000128607.2 UniProtKB/TrEMBL
  ENSMUSP00000133085.2 UniProtKB/TrEMBL
  ENSMUSP00000158389.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000056391 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000078137 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000079327 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113500 UniProtKB/Swiss-Prot
  ENSMUST00000113501.8 UniProtKB/TrEMBL
  ENSMUST00000113502 ENTREZGENE
  ENSMUST00000113502.10 UniProtKB/TrEMBL
  ENSMUST00000113503.10 UniProtKB/TrEMBL
  ENSMUST00000113504 UniProtKB/Swiss-Prot
  ENSMUST00000166909.2 UniProtKB/TrEMBL
  ENSMUST00000170132.2 UniProtKB/TrEMBL
  ENSMUST00000170292.2 UniProtKB/TrEMBL
  ENSMUST00000237909.2 UniProtKB/TrEMBL
InterPro Menin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17283 UniProtKB/Swiss-Prot
MGD MGI:1316736 ENTREZGENE
NCBI Gene 17283 ENTREZGENE
PANTHER PTHR12693 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Menin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Men1 PhenoGen
UniProt A0A0R4J1I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A494BB64_MOUSE UniProtKB/TrEMBL
  D3YZC2_MOUSE UniProtKB/TrEMBL
  E9PV51_MOUSE UniProtKB/TrEMBL
  F6ZTV9_MOUSE UniProtKB/TrEMBL
  F7CJP6_MOUSE UniProtKB/TrEMBL
  F8WHD9_MOUSE UniProtKB/TrEMBL
  MEN1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3U491 UniProtKB/Swiss-Prot
  Q8CI72 UniProtKB/Swiss-Prot
  Q91UZ7 UniProtKB/Swiss-Prot