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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:thyroid gland adenocarcinoma
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Accession:DOID:0080524 term browser browse the term
Definition:A thyroid gland carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:xref: NCI:C27380

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show annotations for term's descendants           Sort by:
follicular thyroid carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:12068308 PMID:12198537 PMID:12960123 PMID:14679157 PMID:15035987 More... NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More... NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27440272 NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166 		JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More... NCBI chrNW_004624766:21,895,967...21,910,727
Ensembl chrNW_004624766:21,896,933...21,907,911 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More... NCBI chrNW_004624772:10,358,554...10,369,371 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO OMIM:188470 MouseDO NCBI chrNW_004624870:3,552,608...3,575,461
Ensembl chrNW_004624870:3,552,745...3,574,880 		JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:24033266 PMID:24055113 PMID:25741868 PMID:25980754 PMID:28492532 More... NCBI chrNW_004624791:13,975,235...14,056,900 JBrowse link
G Srgap1 SLIT-ROBO Rho GTPase activating protein 1 ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:23539728 NCBI chrNW_004624802:4,164,969...4,472,491
Ensembl chrNW_004624802:4,165,054...4,472,293 		JBrowse link
G Thrb thyroid hormone receptor beta ISO CTD Direct Evidence: marker/mechanism
OMIM:188470		 CTD
MouseDO		 PMID:27440272 NCBI chrNW_004624788:1,950,888...2,348,895
Ensembl chrNW_004624788:1,950,890...2,349,343 		JBrowse link
oncocytic carcinoma of the thyroid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbx7 chromobox 7 ISO protein:decreased expression:thyroid Human) RGD PMID:25759796 RGD:11352710 NCBI chrNW_004624752:9,133,587...9,151,216
Ensembl chrNW_004624752:9,133,569...9,151,934 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 ISO ClinVar Annotator: match by term: Hurthle cell carcinoma of the thyroid | ClinVar Annotator: match by term: NDUFA13-related condition OMIM
ClinVar		 PMID:15841082 PMID:25741868 PMID:28492532 NCBI chrNW_004624908:2,311,801...2,319,604
Ensembl chrNW_004624908:2,312,452...2,319,604 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 ISO RGD PMID:19924240 RGD:6483332 NCBI chrNW_004624754:23,811,008...23,815,432
Ensembl chrNW_004624754:23,807,272...23,815,417 		JBrowse link
papillary thyroid carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase susceptibility ISO associated with Radiation-Induced Neoplasms;DNA:SNPs,haplotypes:exon 39,intron 22,intron 48: p.D1853N, IVS22-77 T>C, IVS48 + 238 C>G (rs1801516, rs664677, rs609429)
ClinVar Annotator: match by term: Papillary thyroid carcinoma		 RGD
ClinVar		 PMID:19286843 PMID:19404735 PMID:20305132 PMID:23555315 PMID:25085752 More... RGD:401850780 NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
G Begain brain enriched guanylate kinase associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624734:3,596,499...3,634,255
Ensembl chrNW_004624734:3,596,597...3,634,836 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase onset ISO DNA:mutation:cds:p.V600E(human)
ClinVar Annotator: match by term: Papillary thyroid carcinoma		 RGD
ClinVar		 PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 More... RGD:7241798 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736 		JBrowse link
G Brd4 bromodomain containing 4 ISO mRNA, protein:increased expression:thyroid RGD PMID:26707881 RGD:11085509 NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852 		JBrowse link
G Camk2n1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO mRNA:increased expression:thyroid gland RGD PMID:23569218 RGD:18337285 NCBI chrNW_004624764:5,544,589...5,547,811
Ensembl chrNW_004624764:5,544,484...5,547,683 		JBrowse link
G Cat catalase ISO protein:increased activity:plasma: RGD PMID:20204550 RGD:9068926 NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739 		JBrowse link
G Cbx7 chromobox 7 ISO mRNA:decreased expression:thyroid gland (mouse)
mRNA,protein,DNA:decreased expression, loss of heterozygosity:thyroid gland:		 RGD PMID:18701502 RGD:9587357 NCBI chrNW_004624752:9,133,587...9,151,216
Ensembl chrNW_004624752:9,133,569...9,151,934 		JBrowse link
G Ccdc6 coiled-coil domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624791:3,719,006...3,822,985
Ensembl chrNW_004624791:3,718,961...3,820,089 		JBrowse link
G Ccnd1 cyclin D1 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191 		JBrowse link
G Cdh1 cadherin 1 ISO DNA:hypermethylation:promoter RGD PMID:25520863 RGD:13792554 NCBI chrNW_004624746:17,480,472...17,557,722
Ensembl chrNW_004624746:17,483,469...17,557,581 		JBrowse link
G Ctnnb1 catenin beta 1 disease_progression ISO mRNA:increased expression:thyroid RGD PMID:28677753 PMID:29498921 RGD:13792558 RGD:13792605 NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234 		JBrowse link
G CUNH11orf65 chromosome unknown C11orf65 homolog ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:19404735 PMID:20305132 PMID:23555315 PMID:25085752 PMID:25186627 More... NCBI chrNW_004624784:3,083,664...3,144,017
Ensembl chrNW_004624784:3,084,385...3,145,517 		JBrowse link
G Dio3 iodothyronine deiodinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624734:2,611,864...2,613,932 JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624734:2,253,931...2,311,341
Ensembl chrNW_004624734:2,254,085...2,311,177 		JBrowse link
G Kmt2d lysine methyltransferase 2D ISO associated with familial adenomatous polyposis;DNA:missense mutations, nonsense mutation RGD PMID:32024448 RGD:150523759 NCBI chrNW_004624816:3,129,127...3,169,143
Ensembl chrNW_004624816:3,133,659...3,166,346 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chrNW_004624830:1,320,034...1,422,774
Ensembl chrNW_004624830:1,321,387...1,424,389 		JBrowse link
G Lig4 DNA ligase 4 ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:25741868 NCBI chrNW_004624793:3,699,394...3,706,591
Ensembl chrNW_004624793:3,699,506...3,706,073 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chrNW_004624735:27,780,338...27,784,714
Ensembl chrNW_004624735:27,780,037...27,784,806 		JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004624838:300,902...304,944
Ensembl chrNW_004624838:300,458...305,517 		JBrowse link
G Palb2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004624782:8,752,510...8,780,972
Ensembl chrNW_004624782:8,751,866...8,780,884 		JBrowse link
G Plau plasminogen activator, urokinase severity ISO mRNA:increased expression:thyroid gland (human) RGD PMID:22702340 RGD:7241798 NCBI chrNW_004624754:7,405,637...7,415,870
Ensembl chrNW_004624754:7,408,983...7,416,559 		JBrowse link
G Ppp2r5c protein phosphatase 2 regulatory subunit B'gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624734:2,337,649...2,471,319
Ensembl chrNW_004624734:2,335,243...2,470,811 		JBrowse link
G Rap1gap RAP1 GTPase activating protein ISO protein:decreased expression:thyroid gland (human) RGD PMID:19066305 RGD:9835342 NCBI chrNW_004624764:6,460,230...6,521,693
Ensembl chrNW_004624764:6,460,230...6,506,741 		JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624922:382,462...413,227
Ensembl chrNW_004624922:382,399...413,281 		JBrowse link
G Runx3 RUNX family transcription factor 3 ISO DNA:hypermethylation:promoter RGD PMID:25520863 RGD:13792554 NCBI chrNW_004624764:9,192,067...9,218,617
Ensembl chrNW_004624764:9,191,556...9,248,252 		JBrowse link
G Rxrg retinoid X receptor gamma ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chrNW_004624826:3,723,056...3,969,597
Ensembl chrNW_004624826:3,736,290...3,780,338 		JBrowse link
G Snai1 snail family transcriptional repressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624790:5,509,541...5,515,240
Ensembl chrNW_004624790:5,509,311...5,515,266 		JBrowse link
G Snai2 snail family transcriptional repressor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624735:6,594,564...6,598,288
Ensembl chrNW_004624735:6,594,695...6,598,757 		JBrowse link
G Tp53 tumor protein p53 susceptibility ISO associated with Radiation-Induced Neoplasms;DNA:SNPs, haplotypes:exon 4: p.R72P (rs1042522) (human) RGD PMID:19286843 RGD:401850780 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
G Tpm3 tropomyosin 3 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chrNW_004624885:3,109,360...3,139,664
Ensembl chrNW_004624885:3,109,436...3,139,789 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624734:3,777,866...3,815,369
Ensembl chrNW_004624734:3,782,733...3,817,852 		JBrowse link
G Wdr20 WD repeat domain 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624734:2,145,812...2,205,365
Ensembl chrNW_004624734:2,146,404...2,205,324 		JBrowse link
G Wdr3 WD repeat domain 3 susceptibility ISO DNA:snps, haplotype:introns: c.500+239G>A, c.*1-2382A>C (rs3765501, rs4658973) (human) RGD PMID:20578902 RGD:11041898 NCBI chrNW_004624772:13,588,392...13,626,070
Ensembl chrNW_004624772:13,588,552...13,629,071 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP:exon 10: p.R399Q (rs25487) (Human) RGD PMID:19286843 RGD:401850780 NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624805:3,964,448...4,044,546
Ensembl chrNW_004624805:3,964,450...4,042,527 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chrNW_004624732:44,097,348...44,226,701
Ensembl chrNW_004624732:44,101,613...44,139,997 		JBrowse link
Thyroid Cancer, Nonmedullary, 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxe1 forkhead box E1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 4 OMIM
ClinVar		 PMID:25381600 PMID:25741868 PMID:28444304 PMID:32428920 NCBI chrNW_004624825:2,979,447...2,981,412
Ensembl chrNW_004624825:2,980,176...2,981,303 		JBrowse link
Thyroid Cancer, Nonmedullary, 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Habp2 hyaluronan binding protein 2 ISO ClinVar Annotator: match by term: HABP2-related condition | ClinVar Annotator: match by term: THYROID CANCER, NONMEDULLARY, 5, SUSCEPTIBILITY TO | ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 5 ClinVar
OMIM		 PMID:12138371 PMID:12578864 PMID:15486068 PMID:25741868 PMID:26222560 More... NCBI chrNW_004624737:32,963,943...32,997,789
Ensembl chrNW_004624737:32,964,406...32,995,110 		JBrowse link
Thyroid Carcinoma, Nonmedullary 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166 		JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 OMIM
ClinVar		 PMID:19176457 PMID:25741868 PMID:28492532 NCBI chrNW_004624838:300,902...304,944
Ensembl chrNW_004624838:300,458...305,517 		JBrowse link
G Pcm1 pericentriolar material 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar PMID:10980597 PMID:25741868 NCBI chrNW_004624769:21,153,243...21,262,327 JBrowse link
G Rint1 RAD50 interactor 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar PMID:16199547 PMID:25741868 PMID:28492532 PMID:31204009 PMID:33471991 NCBI chrNW_004624739:24,011,327...24,039,146
Ensembl chrNW_004624739:24,008,072...24,039,215 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14215
    disease of cellular proliferation 6873
      cancer 5074
        cell type cancer 3383
          carcinoma 2864
            adenocarcinoma 1482
              thyroid gland adenocarcinoma 50
                differentiated high-grade thyroid carcinoma + 50
Path 2
Term Annotations click to browse term
  disease 14215
    disease of cellular proliferation 6873
      cancer 5074
        organ system cancer 4867
          endocrine gland cancer 2273
            thyroid cancer 75
              thyroid gland carcinoma 68
                thyroid gland adenocarcinoma 50
                  differentiated high-grade thyroid carcinoma + 50
paths to the root