Lef1 (lymphoid enhancer binding factor 1) - Rat Genome Database

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Gene: Lef1 (lymphoid enhancer binding factor 1) Heterocephalus glaber
Analyze
Symbol: Lef1
Name: lymphoid enhancer binding factor 1
RGD ID: 18903179
Description: ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); beta-catenin binding (ortholog); C2H2 zinc finger domain binding (ortholog); INVOLVED IN alpha-beta T cell differentiation (ortholog); anatomical structure regression (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Disease Models (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); basal cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lymphoid enhancer-binding factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,321,387 - 1,424,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (ISO)
anatomical structure regression  (ISO)
animal organ regeneration  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic process involved in morphogenesis  (ISO)
B cell proliferation  (ISO)
BMP signaling pathway  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (IEA)
cell adhesion  (ISO)
cell chemotaxis  (ISO)
cell development  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-4  (ISO)
chorio-allantoic fusion  (ISO)
dentate gyrus development  (ISO)
embryonic limb morphogenesis  (ISO)
epithelial cell apoptotic process  (ISO)
epithelial to mesenchymal transition  (ISO)
face morphogenesis  (ISO)
forebrain neuroblast division  (ISO)
forebrain radial glial cell differentiation  (ISO)
formation of radial glial scaffolds  (ISO)
hippocampus development  (ISO)
kidney development  (ISO)
mammary gland development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of interleukin-13 production  (ISO)
negative regulation of interleukin-4 production  (ISO)
negative regulation of interleukin-5 production  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neutrophil differentiation  (ISO)
odontoblast differentiation  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
paraxial mesoderm formation  (ISO)
positive regulation of cell cycle process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of chondrocyte proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte differentiation  (ISO)
positive regulation of odontoblast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
protein localization to chromatin  (ISO)
regulation of cell-cell adhesion  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of Wnt signaling pathway  (ISO)
response to organic cyclic compound  (ISO)
secondary palate development  (ISO)
sensory perception of taste  (ISO)
skin development  (ISO)
somitogenesis  (ISO)
sprouting angiogenesis  (ISO)
T cell receptor V(D)J recombination  (ISO)
T-helper 1 cell differentiation  (ISO)
tissue development  (IEA)
tongue development  (ISO)
trachea gland development  (ISO)
transcription by RNA polymerase II  (ISO)
vasculature development  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Lef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,321,387 - 1,424,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
LEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384108,047,548 - 108,168,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4108,047,545 - 108,168,956 (-)EnsemblGRCh38hg38GRCh38
GRCh374108,968,704 - 109,090,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,188,150 - 109,309,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 344109,326,304 - 109,447,182NCBI
Celera4106,263,513 - 106,384,975 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,700,344 - 104,821,596 (-)NCBIHuRef
CHM1_14108,945,152 - 109,066,566 (-)NCBICHM1_1
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBIT2T-CHM13v2.0
Lef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393130,903,972 - 131,018,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)EnsemblGRCm39 Ensembl
GRCm383131,110,297 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBIMGSCv36mm8
Celera3137,630,007 - 137,744,454 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.78NCBI
Lef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,340,541 - 222,453,931 (+)NCBIGRCr8
mRatBN7.22219,666,549 - 219,779,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,666,592 - 219,779,794 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,324,033 - 227,418,775 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,223,708 - 225,318,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,081,321 - 220,176,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,232,115 - 236,345,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,233,239 - 236,345,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,781,171 - 254,893,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,550,263 - 228,673,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,537,002 - 228,659,871 (+)NCBI
Celera2211,924,784 - 212,018,812 (+)NCBICelera
Cytogenetic Map2q43NCBI
Lef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,828,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBIChiLan1.0ChiLan1.0
LEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23106,146,314 - 106,270,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14106,439,278 - 106,565,974 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
LEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,516,002 - 28,633,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,517,108 - 28,634,019 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,389,033 - 13,506,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03228,744,891 - 28,862,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3228,744,919 - 28,862,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13228,737,873 - 28,855,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03228,482,671 - 28,600,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03211,256,345 - 11,374,064 (+)NCBIUU_Cfam_GSD_1.0
Lef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,484,346 - 12,597,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936818453,635 - 567,469 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936818453,635 - 569,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,825,161 - 113,944,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,824,511 - 113,944,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,085,854 - 122,204,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,974,770 - 56,096,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl755,990,621 - 56,094,110 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603734,601,310 - 34,723,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004866217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_004866218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_004866219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_004866220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013066077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013066078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021245457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021245458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021245460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021245461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01083838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01083839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01083840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01083841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01083842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01083843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000016677   ⟹   ENSHGLP00000016508
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248301,321,387 - 1,424,389 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000016678   ⟹   ENSHGLP00000016509
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248301,321,587 - 1,424,389 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000016679   ⟹   ENSHGLP00000016510
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248301,321,808 - 1,422,133 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000016680   ⟹   ENSHGLP00000016511
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248301,322,332 - 1,424,389 (+)Ensembl
RefSeq Acc Id: XM_004866217   ⟹   XP_004866274
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,321,239 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_004866218   ⟹   XP_004866275
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,321,241 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_004866219   ⟹   XP_004866276
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,321,240 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_004866220   ⟹   XP_004866277
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,321,242 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_013066077   ⟹   XP_012921531
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,322,398 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_013066078   ⟹   XP_012921532
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,322,401 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_021245457   ⟹   XP_021101116
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_021245458   ⟹   XP_021101117
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,320,870 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_021245460   ⟹   XP_021101119
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,321,233 - 1,422,774 (+)NCBI
RefSeq Acc Id: XM_021245461   ⟹   XP_021101120
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248301,323,968 - 1,422,774 (+)NCBI
RefSeq Acc Id: XP_021101116   ⟸   XM_021245457
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021101117   ⟸   XM_021245458
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021101119   ⟸   XM_021245460
- Peptide Label: isoform X6
RefSeq Acc Id: XP_004866274   ⟸   XM_004866217
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004866276   ⟸   XM_004866219
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004866275   ⟸   XM_004866218
- Peptide Label: isoform X2
- UniProtKB: G5AQL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004866277   ⟸   XM_004866220
- Peptide Label: isoform X4
- UniProtKB: G5AQL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012921531   ⟸   XM_013066077
- Peptide Label: isoform X5
- UniProtKB: G5AQL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012921532   ⟸   XM_013066078
- Peptide Label: isoform X7
- UniProtKB: G5AQL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021101120   ⟸   XM_021245461
- Peptide Label: isoform X8
- UniProtKB: G5AQL1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016509   ⟸   ENSHGLT00000016678
Ensembl Acc Id: ENSHGLP00000016510   ⟸   ENSHGLT00000016679
Ensembl Acc Id: ENSHGLP00000016508   ⟸   ENSHGLT00000016677
Ensembl Acc Id: ENSHGLP00000016511   ⟸   ENSHGLT00000016680


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011799 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016677 ENTREZGENE
  ENSHGLT00000016678 ENTREZGENE
  ENSHGLT00000016679 ENTREZGENE
  ENSHGLT00000016680 ENTREZGENE
Gene3D-CATH High mobility group box domain UniProtKB/TrEMBL
InterPro CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
NCBI Gene Lef1 ENTREZGENE
PANTHER LYMPHOID ENHANCER-BINDING FACTOR 1 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR 7 FAMILY MEMBER UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP HMG-box UniProtKB/TrEMBL
UniProt G5AQL1 ENTREZGENE, UniProtKB/TrEMBL