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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:silychristin
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Accession:CHEBI:9143 term browser browse the term
Definition:A flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase.
Synonyms:exact_synonym: (2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydro-4H-chromen-4-one
 related_synonym: Formula=C25H22O10;   InChI=1S/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22+,23+,24-/m1/s1;   InChIKey=BMLIIPOXVWESJG-LMBCONBSSA-N;   SMILES=[H][C@@]1(Oc2cc(O)cc(O)c2C(=O)[C@@H]1O)c1cc(O)c2O[C@]([H])([C@H](CO)c2c1)c1ccc(O)c(OC)c1;   silicristina;   silicristine;   silicristinum
 xref: CAS:33889-69-9;   KEGG:C08717;   KNApSAcK:C00001004
 xref_mesh: MESH:C015504
 xref: PMID:118048;   PMID:118049;   PMID:11933142;   PMID:16956731;   PMID:23401473;   Reaxys:6080819


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silychristin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO silychristin results in increased expression of ABCA1 protein CTD PMID:26729088 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO silychristin results in decreased activity of CA1 protein CTD PMID:28445001 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO silychristin results in decreased activity of CA2 protein CTD PMID:28445001 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Ifng interferon gamma multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein] CTD PMID:28914761 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; silychristin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein]; silychristin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:28914761 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein] CTD PMID:28914761 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Pf4 platelet factor 4 multiple interactions ISO silychristin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein] CTD PMID:29439388 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:28914761 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO silychristin results in increased phosphorylation of VASP protein CTD PMID:29439388 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      biological role 19808
        biochemical role 19543
          metabolite 19506
            silychristin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            heteroorganic entity 19474
                              organochalcogen compound 19262
                                organooxygen compound 19153
                                  carbonyl compound 18904
                                    ketone 17170
                                      oxyketone 8905
                                        alpha-oxyketone 8905
                                          alpha-hydroxy ketone 8905
                                            secondary alpha-hydroxy ketone 1041
                                              silychristin 9
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