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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:silychristin
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Accession:CHEBI:9143 term browser browse the term
Definition:A flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase.
Synonyms:exact_synonym: (2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydro-4H-chromen-4-one
 related_synonym: Formula=C25H22O10;   InChI=1S/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22+,23+,24-/m1/s1;   InChIKey=BMLIIPOXVWESJG-LMBCONBSSA-N;   SMILES=[H][C@@]1(Oc2cc(O)cc(O)c2C(=O)[C@@H]1O)c1cc(O)c2O[C@]([H])([C@H](CO)c2c1)c1ccc(O)c(OC)c1;   silicristina;   silicristine;   silicristinum
 xref: CAS:33889-69-9;   KEGG:C08717;   KNApSAcK:C00001004
 xref_mesh: MESH:C015504
 xref: PMID:118048;   PMID:118049;   PMID:11933142;   PMID:16956731;   PMID:23401473;   Reaxys:6080819



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silychristin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO silychristin results in increased expression of ABCA1 protein CTD PMID:26729088 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO silychristin results in decreased activity of CA1 protein CTD PMID:28445001 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO silychristin results in decreased activity of CA2 protein CTD PMID:28445001 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Ifng interferon gamma multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein] CTD PMID:28914761 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; silychristin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein]; silychristin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:28914761 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein] CTD PMID:28914761 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Pf4 platelet factor 4 multiple interactions ISO silychristin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein] CTD PMID:29439388 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO silychristin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:28914761 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO silychristin results in increased phosphorylation of VASP protein CTD PMID:29439388 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            silychristin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbonyl compound 18874
                                    ketone 17181
                                      oxyketone 8903
                                        alpha-oxyketone 8903
                                          alpha-hydroxy ketone 8903
                                            secondary alpha-hydroxy ketone 1037
                                              silychristin 9
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