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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mexiletine
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Accession:CHEBI:6916 term browser browse the term
Definition:An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Synonyms:related_synonym: (+-)-1-(2,6-dimethylphenoxy)propan-2-amine;   (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane;   1-(2',6'-dimethylphenoxy)-2-aminopropane;   1-(2,6-dimethylphenoxy)-2-propanamine;   1-methyl-2-(2,6-xylyloxy)ethanamine;   Formula=C11H17NO;   InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3;   InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N;   SMILES=CC(N)COc1c(C)cccc1C;   mexiletina;   mexiletinum
 alt_id: CHEBI:115958
 xref: CAS:31828-71-4;   DrugBank:DB00379;   Drug_Central:1794;   HMDB:HMDB0014523;   KEGG:C07220;   KEGG:D08215;   LINCS:LSM-1700
 xref_mesh: MESH:D008801
 xref: PMID:10883344;   PMID:11009230;   Patent:FR1551055;   Patent:US3954872;   Reaxys:2092205;   Wikipedia:Mexiletine

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mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Mexiletine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions ISO Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Mexiletine binds to SCN5A protein CTD PMID:22848561 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 increases response to substance ISO SCN9A mRNA SNP results in increased susceptibility to Mexiletine CTD PMID:19162012 NCBI chr 3:52,583,953...52,664,209
Ensembl chr 3:52,583,951...52,664,209 		JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Mexiletine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      application 19403
        pharmaceutical 19303
          drug 19303
            cardiovascular drug 7668
              anti-arrhythmia drug 938
                mexiletine 8
                  mexiletine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19426
                        hydrogen molecular entity 19420
                          hydrides 18753
                            inorganic hydride 17457
                              pnictogen hydride 17433
                                nitrogen hydride 17280
                                  azane 17015
                                    ammonia 17014
                                      organic amino compound 17013
                                        primary amino compound 7950
                                          mexiletine 8
                                            mexiletine hydrochloride 0
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