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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mexiletine
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Accession:CHEBI:6916 term browser browse the term
Definition:An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Synonyms:related_synonym: (+-)-1-(2,6-dimethylphenoxy)propan-2-amine;   (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane;   1-(2',6'-dimethylphenoxy)-2-aminopropane;   1-(2,6-dimethylphenoxy)-2-propanamine;   1-methyl-2-(2,6-xylyloxy)ethanamine;   Formula=C11H17NO;   InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3;   InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N;   SMILES=CC(N)COc1c(C)cccc1C;   mexiletina;   mexiletinum
 alt_id: CHEBI:115958
 xref: CAS:31828-71-4;   DrugBank:DB00379;   Drug_Central:1794;   HMDB:HMDB0014523;   KEGG:C07220;   KEGG:D08215;   LINCS:LSM-1700
 xref_mesh: MESH:D008801
 xref: PMID:10883344;   PMID:11009230;   Patent:FR1551055;   Patent:US3954872;   Reaxys:2092205;   Wikipedia:Mexiletine



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mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Mexiletine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions ISO Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Mexiletine binds to SCN5A protein CTD PMID:22848561 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 increases response to substance ISO SCN9A mRNA SNP results in increased susceptibility to Mexiletine CTD PMID:19162012 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            cardiovascular drug 8621
              anti-arrhythmia drug 1526
                mexiletine 7
                  mexiletine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            inorganic hydride 18151
                              pnictogen hydride 18140
                                nitrogen hydride 18046
                                  azane 17849
                                    ammonia 17848
                                      organic amino compound 17848
                                        primary amino compound 9313
                                          mexiletine 7
                                            mexiletine hydrochloride 0
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