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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mexiletine
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Accession:CHEBI:6916 term browser browse the term
Definition:An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Synonyms:related_synonym: (+-)-1-(2,6-dimethylphenoxy)propan-2-amine;   (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane;   1-(2',6'-dimethylphenoxy)-2-aminopropane;   1-(2,6-dimethylphenoxy)-2-propanamine;   1-methyl-2-(2,6-xylyloxy)ethanamine;   Formula=C11H17NO;   InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3;   InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N;   SMILES=CC(N)COc1c(C)cccc1C;   mexiletina;   mexiletinum
 alt_id: CHEBI:115958
 xref: CAS:31828-71-4;   DrugBank:DB00379;   Drug_Central:1794;   HMDB:HMDB0014523;   KEGG:C07220;   KEGG:D08215;   LINCS:LSM-1700
 xref_mesh: MESH:D008801
 xref: PMID:10883344;   PMID:11009230;   Patent:FR1551055;   Patent:US3954872;   Reaxys:2092205;   Wikipedia:Mexiletine


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mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Mexiletine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions ISO Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Mexiletine binds to SCN5A protein CTD PMID:22848561 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 increases response to substance ISO SCN9A mRNA SNP results in increased susceptibility to Mexiletine CTD PMID:19162012 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:71,553,189...71,701,377 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            cardiovascular drug 8994
              anti-arrhythmia drug 1569
                mexiletine 7
                  mexiletine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        primary amino compound 9437
                                          mexiletine 7
                                            mexiletine hydrochloride 0
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