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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mexiletine
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Accession:CHEBI:6916 term browser browse the term
Definition:An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Synonyms:related_synonym: (+-)-1-(2,6-dimethylphenoxy)propan-2-amine;   (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane;   1-(2',6'-dimethylphenoxy)-2-aminopropane;   1-(2,6-dimethylphenoxy)-2-propanamine;   1-methyl-2-(2,6-xylyloxy)ethanamine;   Formula=C11H17NO;   InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3;   InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N;   SMILES=CC(N)COc1c(C)cccc1C;   mexiletina;   mexiletinum
 alt_id: CHEBI:115958
 xref: CAS:31828-71-4;   DrugBank:DB00379;   Drug_Central:1794;   HMDB:HMDB0014523;   KEGG:C07220;   KEGG:D08215;   LINCS:LSM-1700
 xref_mesh: MESH:D008801
 xref: PMID:10883344;   PMID:11009230;   Patent:FR1551055;   Patent:US3954872;   Reaxys:2092205;   Wikipedia:Mexiletine


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mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055 JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Mexiletine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009 JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions ISO Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 8:119,350,723...119,462,882 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Mexiletine binds to SCN5A protein CTD PMID:22848561 NCBI chr 8:119,220,905...119,318,816 JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 increases response to substance ISO SCN9A mRNA SNP results in increased susceptibility to Mexiletine CTD PMID:19162012 NCBI chr 3:51,145,148...51,293,342 JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Mexiletine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      application 19396
        pharmaceutical 19294
          drug 19294
            cardiovascular drug 7669
              anti-arrhythmia drug 950
                mexiletine 8
                  mexiletine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    main group molecular entity 19651
                      s-block molecular entity 19418
                        hydrogen molecular entity 19413
                          hydrides 18746
                            inorganic hydride 17471
                              pnictogen hydride 17448
                                nitrogen hydride 17302
                                  azane 17009
                                    ammonia 17008
                                      organic amino compound 17007
                                        primary amino compound 7947
                                          mexiletine 8
                                            mexiletine hydrochloride 0
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