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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-erythro-7,8-dihydrobiopterin
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Accession:CHEBI:43029 term browser browse the term
Definition:A 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form.
Synonyms:exact_synonym: 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydropteridin-4(3H)-one
 related_synonym: 7,8-DIHYDROBIOPTERIN;   Dihydrobiopterin;   Formula=C9H13N5O3;   InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,6-/m0/s1;   InChIKey=FEMXZDUTFRTWPE-DZSWIPIPSA-N;   L-erythro-q-Dihydrobiopterin;   Quinonoid dihydrobiopterin;   SMILES=C[C@H](O)[C@H](O)C1=Nc2c(NC1)[nH]c(N)nc2=O;   q-BH2
 alt_id: CHEBI:43011;   CHEBI:43025
 xref: CAS:6779-87-9
 xref_mesh: MESH:C017226
 xref: PDBeChem:HBI;   Reaxys:9715232
 cyclic_relationship: is_enantiomer_of CHEBI:15375


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L-erythro-7,8-dihydrobiopterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases abundance
multiple interactions		 ISO APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin
GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin]		 CTD PMID:22886847 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin] CTD PMID:25041251 PMID:25490417 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Gch1 GTP cyclohydrolase 1 increases abundance
multiple interactions		 ISO GCH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin
[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]		 CTD PMID:25490417 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides] CTD PMID:19011239 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      atom 19832
        nonmetal atom 19770
          nitrogen atom 18959
            nitrogen molecular entity 18959
              organonitrogen compound 18808
                organonitrogen heterocyclic compound 18152
                  pteridines 10261
                    pterins 9413
                      biopterins 11
                        7,8-dihydrobiopterin 4
                          L-erythro-7,8-dihydrobiopterin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            organic molecule 19680
                              organic cyclic compound 19493
                                organic heterocyclic compound 18871
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17245
                                      pteridines 10261
                                        pterins 9413
                                          biopterins 11
                                            7,8-dihydrobiopterin 4
                                              L-erythro-7,8-dihydrobiopterin 4
paths to the root