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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2559
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epo
Name: erythropoietin
Acc ID: CHEBI:43029
Term: L-erythro-7,8-dihydrobiopterin
Definition: A 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form.
Chemical ID: MESH:C017226
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epomultiple interactionsISORGD:105316480464CTDEPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7 8-dihydrobiopterin] EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 7 8-dihydrobiopterin]

PMID:25041251 PMID:25490417
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